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New method targets hidden HIV viral reservoirs during antiretroviral therapy

Scientists at The Wistar Institute may have discovered a new way of identifying and targeting hidden HIV viral reservoirs during treatment with antiretroviral therapy (ART).

10 Aug 2020

Researchers find new way to create natural compound that shows promise as anti-cancer agent

Scripps Research chemists Hans Renata, PhD, and Alexander Adibekian, PhD, have discovered a way to efficiently create a synthetic version of a valuable natural compound called cepafungin I, which has shown promise as an anti-cancer agent.

7 Aug 2020

Discovery Shows Promise For Treating Huntington's Disease

Huntington disease is a progressive debilitating brain disorder that causes uncontrolled movements, psychological problems, and loss of cognition.

6 Aug 2020

Scientists explore the role of epigenetic regulator factors in embryonic development

A research team at the Max Planck Institute for Molecular Genetics in Berlin has explored the role of factors in embryonic development that do not alter the sequence of DNA, but only epigenetically modify its "packaging".

5 Aug 2020

Researchers develop CAR-T cell therapy based on TCR signal transduction

The T cell receptor (TCR) is a key receptor that is responsible for detecting tumor antigens in T cells.

4 Aug 2020

New study can help develop longevity-promoting drugs

Scientists have successfully dialed up and down the lifespan of creatures by changing the activity of proteins present in roundworm cells.

4 Aug 2020

Scientists develop a novel approach to synthesize three-dimensional nanocarbons

A team of scientists led by Kenichiro Itami, Professor and Director of the Institute of Transformative Bio-Molecules (WPI-ITbM), has developed a new method for the synthesis of three-dimensional nanocarbons with the potential to advance materials science.

3 Aug 2020

Detailed 3D structure provides a roadmap for tweaking CRISPR-Cas9–guided base editors

Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy.

31 Jul 2020

Movement of small RNAs underlies mobile RNA interference

Biologists have known for some time that RNA interference can silence genes in far-off cells. They suspected that a messenger substance “transmits” RNA interference.

29 Jul 2020

Supercomputer analyses point to a new pathway for COVID-19 inflammatory response

Analyses of lung fluid cells from COVID-19 patients conducted on a supercomputer point to patterns that may explain the body's response to SARS-CoV-2.

29 Jul 2020

Discovering the Critical Role of Astrocytes in Neurodegenerative Diseases

AZoLifeSciences talks to Dr. Shane Liddelow about their research into discovering the critical role of astrocytes in neurodegenerative diseases like glaucoma.

From New York University (NYU) 29 Jul 2020

Study pinpoints the miRNA that promotes hair follicle growth

A research team from North Carolina State University has discovered a microRNA, or miRNA, that could make hairs to grow again.

29 Jul 2020

Researchers identify how airway cells work together in regeneration and aging

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified the process by which stem cells in the airways of the lungs switch between two distinct phases -- creating more of themselves and producing mature airway cells -- to regenerate lung tissue after an injury.

28 Jul 2020

A novel approach to identify cancer targets using 'synthetic lethality'

With advances in genome sequencing, cancer treatments have increasingly sought to leverage the idea of "synthetic lethality," exploiting cancer-specific genetic defects to identify targets that are uniquely essential to the survival of cancer cells.

28 Jul 2020

Virginia Tech scientists reveal molecular cause underlying rare genetic disorder

Virginia Tech scientists have revealed how a nonfunctioning version of an ordinary gene impairs brain structure and function. The findings help explain a genetic form of microcephaly -- a condition where babies' heads are small and grow more slowly than their peers.

28 Jul 2020

Heparin blocks SARS-CoV-2 infection in cell studies

In a test of antiviral effectiveness against the virus that causes COVID-19, an extract from edible seaweeds substantially outperformed remdesivir, the current standard antiviral used to combat the disease.

27 Jul 2020

Higher levels of specific protein linked with severity of COVID-19 symptoms

A new study found raised levels of transforming growth factor beta-induced protein (TGFBIp) in blood sampled from roughly 100 people hospitalized for COVID-19, and further found that elevated levels of both the normal and acetylated forms of TGFBIp correlated with the severity of disease symptoms in these patients.

27 Jul 2020

New approach is more effective in treating certain blood cancers

Some of the most promising advances in cancer treatment have centered on immunotherapies that rev up a patient's immune system to attack cancer.

24 Jul 2020

Epigenomic data can help characterize genes that play key role in cancer progression

As cancer cells evolve, many of their genes become overactive while others are turned down. These genetic changes can help tumors grow out of control and become more aggressive, adapt to changing conditions, and eventually lead the tumor to metastasize and spread elsewhere in the body.

From Massachusetts Institute of Technology (MIT) 24 Jul 2020

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling.

23 Jul 2020

Molecule News and Research

New method targets hidden HIV viral reservoirs during antiretroviral therapy

Researchers find new way to create natural compound that shows promise as anti-cancer agent

Discovery Shows Promise For Treating Huntington's Disease

Scientists explore the role of epigenetic regulator factors in embryonic development

Researchers develop CAR-T cell therapy based on TCR signal transduction

New study can help develop longevity-promoting drugs

Scientists develop a novel approach to synthesize three-dimensional nanocarbons

Detailed 3D structure provides a roadmap for tweaking CRISPR-Cas9–guided base editors

Movement of small RNAs underlies mobile RNA interference

Supercomputer analyses point to a new pathway for COVID-19 inflammatory response

Discovering the Critical Role of Astrocytes in Neurodegenerative Diseases

Study pinpoints the miRNA that promotes hair follicle growth

Researchers identify how airway cells work together in regeneration and aging

A novel approach to identify cancer targets using 'synthetic lethality'

Virginia Tech scientists reveal molecular cause underlying rare genetic disorder

Heparin blocks SARS-CoV-2 infection in cell studies

Higher levels of specific protein linked with severity of COVID-19 symptoms

New approach is more effective in treating certain blood cancers

Epigenomic data can help characterize genes that play key role in cancer progression

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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