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A gene is a unit of heredity in a living organism. It normally resides on a stretch of DNA that codes for a type of protein or for an RNA chain that has a function in the organism. All living things depend on genes, as they specify all proteins and functional RNA chains.

Revealing how cohesin attaches to the DNA and forms loops

Ana Losada, a scientist at the Spanish National Cancer Research Centre (CNIO) and then at the Cold Spring Harbor Laboratory, identified cohesin, a protein essential to the process of cell division, in Xenopus frogs at the end of the 1990s.

5 Apr 2023

Male Beetles Neglect Maintenance of Gametes When Competing for Mating Opportunities

Male beetles face a trade-off between competing with other males for mating opportunities and repairing damage to their sperm DNA, according to a study publishing April 4th in the open access journal PLOS Biology by Mareike Koppik from Uppsala University, Sweden, and colleagues.

5 Apr 2023

Novel Genes Could Serve as Predictive Biomarkers for PARP Inhibitor Response in Prostate Cancer

Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive.

5 Apr 2023

Tiny Protein Interacts with Ion Channels to Make Our Eyes Sensitive to Dim Light

Using cryo-electron microscopy and mass spectrometry, researchers from PSI have deciphered the structure of an ion channel found in the eye while it interacts with the protein calmodulin – a structure that has eluded scientists for three decades.

4 Apr 2023

Potential Treatment Pathway for IBD Emerges from Microbe-Gut Signaling Study

Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.

4 Apr 2023

Endothelial Deletion of Wt1 Gene During Coronary Vessel Formation Affects Embryonic Heart Development

How is the mammals' heart formed? What role do endothelial cells play? Do the same pathways and genes involved in the formation of the embryonic heart also play a role in repair processes?

4 Apr 2023

SARS-CoV-2 Spike Protein Induces Memory Loss After COVID-19

Patients diagnosed with post-COVID-19 syndrome often experience cognitive and memory impairments.

4 Apr 2023

Jumping Genes in Various Cancers may be Used to Direct Novel Immunotherapies to Tumors

New research from Washington University School of Medicine in St. Louis suggests that transposable elements in various cancers potentially may be used to harness novel immunotherapies against tumors that don't typically respond to immune-based treatments. Shown is a 3D rendering of cancer cells.

4 Apr 2023

Designing a Lipid Nanoparticle to Safely Deliver mRNA to the Pancreas

Therapeutics that use mRNA-;like some of the COVID-19 vaccines-;have enormous potential for the prevention and treatment of many diseases.

4 Apr 2023

New Resource Provides a Better Annotation of the Genome and Understanding of Variant Impact

Each person has about 4 million sequence differences in their genome relative to the reference human genome.

4 Apr 2023

KAI2-Ligand Signaling Pathway Responsible for Regulating Vegetative Reproduction in Liverwort Plants

Asexual, or vegetative, reproduction in plants is controlled by environmental conditions, but the molecular signaling pathways that control this process are poorly understood.

3 Apr 2023

Newly Identified Rare Genetic Variants Could Point to One of the General Mechanisms Driving AMD

A study from the National Eye Institute (NEI) identified rare genetic variants that could point to one of the general mechanisms driving age-related macular degeneration (AMD), a common cause of vision loss in older adults.

3 Apr 2023

Study Represents a Paradigm Shift in Renal Physiology/Mammalian Salt Handling

A new study led by Marshall University researchers focuses on a novel mechanism of the body's regulation of salt balance.

3 Apr 2023

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.

3 Apr 2023

Gene News and Research

Further Reading

Revealing how cohesin attaches to the DNA and forms loops

Male Beetles Neglect Maintenance of Gametes When Competing for Mating Opportunities

Novel Genes Could Serve as Predictive Biomarkers for PARP Inhibitor Response in Prostate Cancer

Tiny Protein Interacts with Ion Channels to Make Our Eyes Sensitive to Dim Light

Potential Treatment Pathway for IBD Emerges from Microbe-Gut Signaling Study

Endothelial Deletion of Wt1 Gene During Coronary Vessel Formation Affects Embryonic Heart Development

SARS-CoV-2 Spike Protein Induces Memory Loss After COVID-19

Jumping Genes in Various Cancers may be Used to Direct Novel Immunotherapies to Tumors

Designing a Lipid Nanoparticle to Safely Deliver mRNA to the Pancreas

New Resource Provides a Better Annotation of the Genome and Understanding of Variant Impact

KAI2-Ligand Signaling Pathway Responsible for Regulating Vegetative Reproduction in Liverwort Plants

Newly Identified Rare Genetic Variants Could Point to One of the General Mechanisms Driving AMD

Study Represents a Paradigm Shift in Renal Physiology/Mammalian Salt Handling

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

Newly developed toolkit uses small molecules to control the activity of synthetic RNA

New cold "coping" mechanism of plants could offer solutions to breeding more climate resilient crops

Gene variants that improve nitrogen utilization identified

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Harnessing a natural bacterial system to deliver proteins in mice and human cells

Single monoclonal antibody infusion can strengthen the body's fight against yellow fever

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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