Genetic News and Research

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New Culture System may Improve Efficiency and Safety of Genome Editing in HSCs

Hematopoietic stem cells (HSCs) are rare cells found in the bone marrow that produce red blood cells, white blood cells, and platelets.

11 Jul 2023

T cells are Sensitive to Genetic Disturbances Within Mitochondrial Power Plants

All cells have their own power plants, called mitochondria. There are often more than 100 mitochondria per cell and each possesses their own genome, which in turn contains genes responsible for energy production.

7 Jul 2023

Genetic Changes in Maize Reveal Trade-Offs in Heat Tolerance

The ability of crops to withstand heat is critical to our food system's resilience to climate change. A study published in the open access journal PLOS Genetics by Aaron Kusmec at Iowa State University; Ames, Iowa, United States and colleagues suggests that trait selection through plant breeding has increased maize's tolerance to moderate heat stress over time; however, its tolerance to severe heat stress has decreased.

7 Jul 2023

Researchers Develop New Way to Genetically Suppress Malaria-Carrying Mosquitoes

Malaria remains one of the world's deadliest diseases. Each year malaria infections result in hundreds of thousands of deaths, with the majority of fatalities occurring in children under five.

6 Jul 2023

Study Uncovers Candidate Genes That may Drive Inflammatory Bowel Disease

A study of the genetic variation that makes mice more susceptible to bowel inflammation after a high-fat diet has identified candidate genes which may drive inflammatory bowel disease (IBD) in humans.

6 Jul 2023

New Method Reveals How Hepatitis C Virus Evades Immune System

With a new method for examining virus samples researchers from the University of Copenhagen have solved an old riddle about how Hepatitis C virus avoids the human body's immune defenses.

6 Jul 2023

Glutaminase 2 Plays a Key Role in Glucose Homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

6 Jul 2023

Negative Modulation of Arabidopsis Salinity Tolerance by CONSTANS Protein

Arabidopsis (Arabidopsis thaliana)’s photoperiodically controlled flowering and circadian pathways are primarily regulated by CONSTANS (CO), a well-known B-box family member.

5 Jul 2023

Gut Microbes Could Be Harnessed to Block Mercury Absorption

New research by a team at Pennsylvania State University suggests that microbes in the human gut could be harnessed to block absorption of toxic metals like mercury and help the body absorb useful nutritional ones, like iron.

5 Jul 2023

Host Genetics Affects Composition of Switchgrass Root Microbiome

Plants provide a home for a wide diversity of microbes, especially in their roots. In turn, these communities can provide important benefits for the host.

5 Jul 2023

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

According to new research published in Nature Biotechnology, artificial intelligence can predict on- and off-target behavior of CRISPR tools that target RNA rather than DNA.

5 Jul 2023

Genetically Modified iPS Cell Applications for Fabry Disease

iPS cells have had a significant impact on biology and medicine, and they are expected to increase regenerative medicine. Clinical trials with various cell types derived from iPS cells have been performed since 2014 when a sheet of retinal pigment epithelial cells obtained from iPS cells was transplanted into patients with age-related macular degeneration.

4 Jul 2023

New AI Tool Tracks Complex Fruit Fly Behavior

What is the easiest way to know if a fruit fly is hungry? Ask a computer.

3 Jul 2023

Ancient Virus-Like Transposons Found to Mediate Horizontal Gene Transfer in Worms

Scientists have known for decades that genes can be transferred from one species to another, both in animals and plants.

30 Jun 2023

Identifying the Genetic Variant That Increases Disease Severity in MS

Research of over 22,000 patients with multiple sclerosis (MS) has for the first time discovered a genetic variant linked with speedier progression of the disease, a buildup of disability that can deprive patients of their mobility and independence over time.

29 Jun 2023

The First Programmable RNA-Guided System in Eukaryotes Uncovered

Feng Zhang of the Broad Institute at MIT and Harvard and the McGovern Institute for Brain Research at MIT headed a team of researchers who discovered the first programmable RNA-guided mechanism in eukaryotes, which include fungi, plants, and animals.

29 Jun 2023

New Breakthrough of Genetic Marker Improves Treatment for Multiple Sclerosis

A study of more than 22,000 people with multiple sclerosis has discovered the first genetic variant associated with faster disease progression, which can rob patients of their mobility and independence over time.

29 Jun 2023

Analyzing the Role of Pyroptosis in Improving the Treatment of Lung Cancer

Lung cancer, one of the most aggressive forms of cancer, continues to be a leading cause of death worldwide. Although several new therapies have been developed for this disease, it has a poor prognosis in its advanced stages.

29 Jun 2023

Disclosing the Key Role of Mitofusin 2 Cellular Makeup in Interconnecting Organelles Within Cells

Researchers at IRB Barcelona, the University of Barcelona (UB), VIMM, and the University of Padua unveil the key role of Mitofusin 2 cellular makeup in interconnecting organelles within cells.

29 Jun 2023

New AI-Assisted Methods to Discover Novel Deaminase Proteins with Unique Functions

At the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, GAO Caixia’s group has introduced the use of artificial intelligence (AI)-assisted techniques to find out novel deaminase proteins with special functions via structural prediction and classification.

28 Jun 2023