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Scientists Reinvent Spectinomycin as a Powerhouse Weapon for Drug-Resistant Superbug

Scientists at St. Jude Children's Research Hospital are tackling Mycobacterium abscessus (Mab) antibiotic resistance.

10 Jan 2024

Key Cytokine Pairs Driving Sepsis Damage Identified

One of the main causes of death in the ICU is sepsis, which is the result of an infection that causes the immune system to mistakenly target the body.

9 Jan 2024

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Amino acids, such as tyrosine and tryptophan, are the fundamental building blocks that make up proteins.

9 Jan 2024

AI Tool Offers a Deep Dive Into Tissues, Boosting Cancer Detection and Treatment

A new artificial intelligence tool that interprets medical images with unprecedented clarity does so in a way that could allow time-strapped clinicians to dedicate their attention to critical aspects of disease diagnosis and image interpretation.

3 Jan 2024

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

29 Dec 2023

Zebrafish Embryo Model Unveils Breakthrough Cultivation Method

Researchers at the National University of Singapore (NUS) specializing in food virology have achieved successful cultivation of the human norovirus using zebrafish embryos.

29 Dec 2023

Xeno-Free Monkey PSC Culture System Enables Deriving, Tracking, and Differentiating Stem Cells

Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.

26 Dec 2023

The Adrenaline Puzzle Solved: Scientists Untangle Key Cell Receptor's Inner Workings

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

26 Dec 2023

The Impact of Gut Microbiome Communities on Pathogen Protection

The gut microbiome, comprising numerous bacterial species, serves as a residence for various bacteria within the human digestive system.

15 Dec 2023

Novel DNA Tension Probe Technology Offers Precise Measurement of Platelet Function

A novel technique to test platelet function within a person's blood sample is faster, easier and more precise than methods currently in use, an experimental study shows.

12 Dec 2023

Tailored Nanoparticles Deliver siRNA to Reduce Neuroinflammation in Alzheimer's Disease Models

Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells.

11 Dec 2023

Deciphering the Chemistry Behind Antibody Tetramerization

Novel insights into antibody aggregation are anticipated to pave the way for fresh avenues in both research and therapeutic applications.

11 Dec 2023

A Breakthrough in Combatting Multi-Drug Resistant Bacteria

Healthcare-associated infections pose a widespread challenge in the treatment of suppurating wounds, compounded by the escalating prevalence of multi-drug resistant bacteria.

6 Dec 2023

New Irreversible Inhibitor Overcomes Drug Resistance in Cancer Cells

The concept of irreversible inhibitors binding permanently to a target protein has garnered growing interest for potential applications in drug development.

30 Nov 2023

Could A Small Flower Hold The Key to More Stable Peptide Drugs?

Taking inspiration from a small purple flower found in the tropics, University of Bath scientists have successfully created a new tool that could help to create more stable, efficient and cost-effective drugs.

29 Nov 2023

Unveiling the Role of Heat Shock Proteins

A protective function against protein clumping is provided by a heat shock protein within cells.

27 Nov 2023

Engineering Stem Cells to Evade Immune Rejection

Cell and organ transplants have the potential to save lives; however, patients frequently face prolonged waiting periods as a result of the insufficient availability of suitable donors.

23 Nov 2023

A Glimpse into Future: Bioprinted Organs May Become Reality in Two Decades

In recent years, 3D printing has emerged as a transformative technology for the field of organ transplantation. Doctors are already using 3D-printed skin for burn treatment and wound healing, and this year has seen the first successful use of 3D-printed cartilage for ear reconstruction.

22 Nov 2023

How 3D-Printed Organs Could Reduce Use of Animal Testing in Medical Research

In the realm of scientific research, particularly in the medical and pharmaceutical sectors, animal testing has been a prevalent method.