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Programmable G-protein-coupled receptors redefine therapeutic applications.

This study demonstrates the development of PAGERs (programmable antigen-gated engineered receptors), combining antigen specificity, modular adaptability, and drug-controlled activation, with potential applications in synthetic biology, therapeutics, and neuroscience.

12 Dec 2024

Genetic Mutation in the Inherited DNA Found to Drive Breast Cancer Metastasis

Ninety percent of cancer deaths are due to the spread of cancer, not complications from the original tumor.

10 Dec 2024

Study Reveals How Toxoplasma Parasite Evades Drug Treatment by Altering Protein Production

A study by Indiana University School of Medicine researchers sheds new light on how Toxoplasma gondii parasites make the proteins they need to enter a dormant stage that allows them to escape drug treatment.

10 Dec 2024

New Era of Combined mRNA and RNAi Therapies

Researchers at the University of Ottawa have figured out how to use mRNA and RNAI-based treatments to treat complex illnesses like cancer and heart disease.

10 Dec 2024

Brazilian Study Offers Fresh Perspectives on Pancreatic Cancer Genetics

Pancreatic cancer has recently been included in the list of diseases about which Brazil's National Cancer Institute (INCA) periodically publishes statistics.

9 Dec 2024

New Study Challenges Traditional View of Axon Shape and Function

In a provocative new study, scientists challenge a fundamental tenet in neuroscience about the shape of axons -- the long, thin filaments radiating from nerve cells that transmit electrical signals from cell to cell – and propose a new model for understanding how information is transmitted in the brain.

9 Dec 2024

Novel Approach to Monitor ER-Related Protein Quality Control

Protein synthesis in eukaryotic cells found in plants, animals, and fungi involves more than just the straightforward ribosome assembly of amino acids.

9 Dec 2024

Key Enzymes Identified as Regulators of Cancer Cell Nutrient Foraging

Cancer cells are like booming cities without urban planners. They expand quickly, and in doing so, the resulting tumors consume more energy and other resources than they can acquire from nearby blood vessels.

6 Dec 2024

Single Mutation Could Make H5N1 Bird Flu More Dangerous to Humans

Avian influenza viruses typically require several mutations to adapt and spread among humans, but what happens when just one change can increase the risk of becoming a pandemic virus?

6 Dec 2024

Poplar Gene Found to Enhance Photosynthesis and Boost Tree Growth

A team of scientists from the Center for Advanced Bioenergy and Bioproducts Innovation at the University of Illinois Urbana-Champaign and the Center for Bioenergy Innovation at Oak Ridge National Laboratory identified a gene in poplar trees that enhances photosynthesis and can boost tree height.

4 Dec 2024

Peat Bog Fungi as a Reservoir of Anti-Tuberculosis Compounds

An analysis of fungi collected from peat bogs has revealed several species that produce substances toxic to the bacterium responsible for tuberculosis in humans.

4 Dec 2024

Amborella trichopoda sheds light on ZW sex chromosome evolution in angiosperm plants

A recent study characterizes the ZW sex chromosomes in Amborella trichopoda, revealing insights into sex determination and early evolutionary dynamics in plants.

4 Dec 2024

Research Sheds Light on Protein's Role in Enhancing Plant Disease Resistance

Salicylic acid is vital for protecting plants from pathogens, but its synthesis remains unclear. A recent study by Shinshu University researchers has discovered that the protein HSR201 is key to its production.

3 Dec 2024

Novel Organoid Model Sheds Light on Human Pancreas Development and Disease

A new organoid that resembles the human fetal pancreas has been created by researchers in the organoid group, providing an understanding of its early development.

3 Dec 2024

Understanding Gut Inflammation Through RNA Sequencing

This study creates a comprehensive atlas of gastrointestinal cell types, revealing how stem cell-derived INFLAREs drive inflammation in chronic diseases.

29 Nov 2024

New Light-Driven Biohybrid System Supports Precise Photoimmunotherapy

In a study published in Cell Reports Physical Science on Nov. 25, a research team led by Prof. CAI Lintao from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences reported its development of an innovative intelligent light-guided biohybrid system, the CTPA/siCSF1R system, to target tumor-associated macrophages (TAMs), thus enabling precise spatiotemporal siRNA delivery.

28 Nov 2024

Cold Acclimation Enhances Photoinhibition Repair in Plants

Plants need light to grow, but too much light can induce damage to the photosynthetic complex known as photosystem II.

28 Nov 2024

Unveiling the Antimicrobial Potential of 28 Actinomycetes

Researchers from the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH's Department Bioresources for Bioeconomy and Health Research, under the direction of Dr. Imen Nouioui and Professor Dr. Yvonne Mast, have characterized 28 actinomycetes and examined their potential for biotechnology.

28 Nov 2024

Study Reveals Molecular Mechanism Behind Neural Fate Commitment

The Wistar Institute's Alessandro Gardini, Ph.D., and lab have shed new light on how certain biological processes determine the development of neural cells. Their findings on a molecular "bridge" complex demonstrate a new level of detail in the understanding of early neural development -; which is fundamental for the further understanding of neurodevelopmental syndromes.

27 Nov 2024

Cyanobacteria Harness Pulse Amplitude Modulation to Control Biological Functions

Cyanobacteria, an ancient lineage of bacteria that perform photosynthesis, have been found to regulate their genes using the same physics principle used in AM radio transmission.

26 Nov 2024