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Researchers Identify Novel Role of a Protein in the Development of Alcohol-Associated Liver Disease

Alcohol-associated liver disease (ALD), a complex disorder that occurs in some patients who have engaged in excessive alcohol use, is one of the leading causes of chronic liver disease among veterans and liver transplant patients in the United States.

19 Apr 2023

Entry of Aging-Associated Enzymes into Human Genetic Material

An enzyme that controls aging and other metabolic processes accesses human genetic material to modify gene expression within the cell, according to a new study. Images of a sirtuin enzyme bound to a nucleosome, a tightly packed complex of DNA and proteins called histones, have been created by a team led by Penn State researchers.

17 Apr 2023

Glycine-Based Tripeptide Treats Severe Form of Fatty Liver Disease in Non-Human Primates

A recently developed amino acid compound successfully treats nonalcoholic fatty liver disease in non-human primates -; bringing scientists one step closer to the first human treatment for the condition that is rapidly increasing around the world, a study suggests.

11 Apr 2023

Research Reveals Why Viruses can Reinfect a Population of Previously Immune Hosts

The human body is capable of creating a vast, diverse repertoire of antibodies-;the Y-shaped sniffer dogs of the immune system that can find and flag foreign invaders.

7 Apr 2023

Analyzing the Connection Between Genes, Brain Characteristics, and Behavior

Intelligence is presumably heritable. Certain genetic variations have been linked to higher intelligence test performance in research. Other research has linked intelligence to a number of brain characteristics, like network efficiency.

5 Apr 2023

Role of Engineered E. coli in Sending Therapeutic Nanobodies to the Gut

Numerous bacterium types have taken up residence in humans. Currently, research is concentrated on genetically modifying these bacteria to increase their inherent therapeutic qualities.

5 Apr 2023

Cellular Recycling Function in the Brain Slows Dramatically After Traumatic Brain Injury

Each year about 1.5 million people in the U.S. survive a traumatic brain injury due to a fall, car accident, or a sports injury, which can cause immediate and long-term disability.

5 Apr 2023

Dengue Viruses Subvert Mosquito Biology to Tamp Down Human Immune Responses

The saliva of mosquitoes infected with dengue viruses contains a substance that thwarts the human immune system and makes it easier for people to become infected with these potentially deadly viruses, new research reveals.

5 Apr 2023

New Resource Provides a Better Annotation of the Genome and Understanding of Variant Impact

Each person has about 4 million sequence differences in their genome relative to the reference human genome.

4 Apr 2023

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

31 Mar 2023

Clearance of senescent cells by boosting anti-viral immune response

Aging, or senescent cells, which stop dividing but don't die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders.

31 Mar 2023

Neutrophils can affect the success of immunotherapy in treating cancer, study shows

Cancer immunotherapies that recruit a patient's own immune system to destroy tumors have transformed the treatment of many types of cancer. Yet these therapies do not elicit universally good treatment responses.

31 Mar 2023

Ancient DNA reveals African founders intermingled with southwest Asian people around 1000 CE

While serfs toiled and knights jousted in Europe and samurai and shoguns rose to power in Japan, the medieval peoples of the Swahili civilization on the coast of East Africa lived in multicultural, coral-stone towns and engaged in trade networks spanning the Indian Ocean.

30 Mar 2023

New nanoparticles can perform gene editing in the lungs, paving the way for inhalable therapies

Nanoparticles can be used to deliver messenger RNA encoding proteins to the lungs, results of a new study carried out at MIT and the University of Massachusetts Medical School show.

From Massachusetts Institute of Technology (MIT) 30 Mar 2023

Innovative new approach to constructing a nose in young patients with arhinia

Congenital arhinia (meaning patients born without a nose) is a rare condition associated with high mortality if not identified.

24 Mar 2023

Common Epstein-Barr virus may be a trigger for multiple sclerosis

In 1868, French physician Jean-Martin Charcot, known as the founder of modern neurology, defined a disease entity in which multiple plaques formed in the brain and spinal cord, with varying physical symptoms, called Sclérose en plaques, or in English as multiple sclerosis (MS).

24 Mar 2023

Using AI to screen for genetic mutations in cancerous brain tumors in under 90 seconds

Using artificial intelligence, researchers have discovered how to screen for genetic mutations in cancerous brain tumors in under 90 seconds -; and possibly streamline the diagnosis and treatment of gliomas, a study suggests.

24 Mar 2023

Delaying paralysis in ALS by using designer DNA drug

In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell.

20 Mar 2023

Analyzing the antimicrobial resistance profile of the main agent of urinary tract infections

The human intestine is an environment inhabited by many bacteria and other microorganisms collectively known as the gut microbiome, gut microbiota or intestinal flora. In most people, it contributes to wellness. A healthy gut indicates a stronger immune system, improved metabolism, and a healthy brain and heart, among other functions.

14 Mar 2023

New class of oral drugs inhibits a diverse range of SARS-CoV-2 strains

The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections. Researchers have now discovered that a new class of oral drugs that acts directly on human cells can inhibit a diverse range of pathogenic SARS-CoV-2 strains.

13 Mar 2023

Medical School News and Research

Researchers Identify Novel Role of a Protein in the Development of Alcohol-Associated Liver Disease

Entry of Aging-Associated Enzymes into Human Genetic Material

Glycine-Based Tripeptide Treats Severe Form of Fatty Liver Disease in Non-Human Primates

Research Reveals Why Viruses can Reinfect a Population of Previously Immune Hosts

Analyzing the Connection Between Genes, Brain Characteristics, and Behavior

Role of Engineered E. coli in Sending Therapeutic Nanobodies to the Gut

Cellular Recycling Function in the Brain Slows Dramatically After Traumatic Brain Injury

Dengue Viruses Subvert Mosquito Biology to Tamp Down Human Immune Responses

New Resource Provides a Better Annotation of the Genome and Understanding of Variant Impact

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Clearance of senescent cells by boosting anti-viral immune response

Neutrophils can affect the success of immunotherapy in treating cancer, study shows

Ancient DNA reveals African founders intermingled with southwest Asian people around 1000 CE

New nanoparticles can perform gene editing in the lungs, paving the way for inhalable therapies

Innovative new approach to constructing a nose in young patients with arhinia

Common Epstein-Barr virus may be a trigger for multiple sclerosis

Using AI to screen for genetic mutations in cancerous brain tumors in under 90 seconds

Delaying paralysis in ALS by using designer DNA drug

Analyzing the antimicrobial resistance profile of the main agent of urinary tract infections

New class of oral drugs inhibits a diverse range of SARS-CoV-2 strains

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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