Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Genomic test helps identify prostate cancer patients who may benefit from hormone therapy

A commercially available genomic test may help oncologists better determine which patients with recurrent prostate cancer may benefit from hormone therapy, according to new research from the Johns Hopkins Kimmel Cancer Center and 15 other medical centers.

12 Feb 2021

Researchers discover new molecular mechanism that promotes cell migration

Research groups at the University of Helsinki and Institut Jacques Monod, Paris, discovered a new molecular mechanism that promotes cell migration. The discovery sheds light on the mechanisms that drive the uncontrolled movement of cancer cells and also revises the 'textbook view' of cell migration.

10 Feb 2021

Unique proteomics-based technology can help diagnose breast cancer more accurately

Breast cancer could be identified more precisely than existing methods using blood specimens and exclusive proteomics-based technology.

28 Jan 2021

Drug-resistant, metastasis-causing cells produce exponentially growing tumors

The cover for issue 1 of Oncotarget features Figure 2, "Results in clinical trials," published in "Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer" by Blagoev, et al. which reported that most metastatic cancers develop drug resistance during treatment and continue to grow, driven by a subpopulation of cancer cells unresponsive to the therapy being administered.

27 Jan 2021

New mathematical model captures forces involved in cell movement

Physicists have teamed up to find out the precise mechanisms that play a crucial role in cell motility.

19 Jan 2021

Protein phosphatase inhibition could contribute to the treatment of cancer, other diseases

The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator of cancer aggressiveness and metastatic potential.

13 Jan 2021

Chromosomal instability is associated with cancer's aggressiveness

Cancer cells are known for spreading genetic chaos. As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether.

29 Dec 2020

Researchers detect new immune cells that act as major driver of breast cancer growth

Several breast cancer immunotherapies have had only minimal success in treating the aggressive forms of this disease.

17 Dec 2020

Study elucidates genes responsible for Glioblastoma invasiveness

One of the hallmarks of Glioblastoma (GBM), the most aggressive type of brain cancer, is its high invasive capacity, which leads to its expansion into the normal brain tissue.

14 Dec 2020

Study reveals new target to make breast cancer more sensitive to immunotherapy

Although immunotherapy has been effective in treating different kinds of cancer, it is still unsuccessful when it comes to treating breast cancers.

11 Dec 2020

Biologists unravel how tissue geometry influences cell migration

Cells move constantly throughout our bodies, performing myriad operations critical to tissue development, immune responses, and general wellbeing. This bustle is guided by chemical cues long studied by scientists interested in cellular migration.

23 Nov 2020

New method could more sensitively detect circulating tumor cells

Breast cancer is the most frequently diagnosed cancer in women, and metastasis from the breast to other areas of the body is the leading cause of death in these patients.

19 Nov 2020

Genetic signature in localized prostate cancer can predict likelihood of tumor metastases

Researchers have identified a genetic signature in localized prostate cancer that can predict whether the cancer is likely to spread, or metastasize, early in the course of the disease and whether it will respond to anti-androgen therapy, a common treatment for advanced disease.

11 Nov 2020

Scientists reveal molecular mechanism that increases the invasiveness of radioresistant cancer cells

Scientists have revealed the molecular mechanism regulating the trafficking of lysosomes that increases the invasiveness of radioresistant cancer cells following radiotherapy.

30 Oct 2020

Myeloid cell can suppress the immune response to tumor cells

For a long time, researchers had believed that the brain reduces inflammation by protecting itself from an aggressive immune response.

28 Oct 2020

RNA-centric mechanism regulates microRNAs linked to cancer, neurological disorders

MicroRNAs are small non-coding RNAs—that is, bits of genetic code that act as key gene regulators in various aspects of biological processes.

28 Oct 2020

Researchers use new technique to find undetectable ‘hot spots’ inside aggressive breast cancer

Using a new technique, a team of McGill University researchers has found tiny and previously undetectable 'hot spots' of extremely high stiffness inside aggressive and invasive breast cancer tumors.

28 Oct 2020

Researchers discover new ways to block the colonization and spread of tumor cells

What role do the lymphatic vessels play in the metastasis of cancer cells? Scientists from the German Cancer Research Center and the Mannheim Medical Faculty of the University of Heidelberg developed a method to investigate this question in mice.

27 Oct 2020

Researchers identify new potential therapeutic targets for SARS-CoV-2 infection

To identify new potential therapeutic targets for SARS-CoV-2, a team of scientists at the New York Genome Center, New York University, and the Icahn School of Medicine at Mount Sinai, performed a genome-scale, loss-of-function CRISPR screen to systematically knockout all genes in the human genome.

27 Oct 2020

Researchers identify a promising target for treating chemo-resistant cancer cells

As medical professionals and scientists work to design new therapies for cancer, they come across a range of difficulties.

26 Oct 2020

Metastasis News and Research

Genomic test helps identify prostate cancer patients who may benefit from hormone therapy

Researchers discover new molecular mechanism that promotes cell migration

Unique proteomics-based technology can help diagnose breast cancer more accurately

Drug-resistant, metastasis-causing cells produce exponentially growing tumors

New mathematical model captures forces involved in cell movement

Protein phosphatase inhibition could contribute to the treatment of cancer, other diseases

Chromosomal instability is associated with cancer's aggressiveness

Researchers detect new immune cells that act as major driver of breast cancer growth

Study elucidates genes responsible for Glioblastoma invasiveness

Study reveals new target to make breast cancer more sensitive to immunotherapy

Biologists unravel how tissue geometry influences cell migration

New method could more sensitively detect circulating tumor cells

Genetic signature in localized prostate cancer can predict likelihood of tumor metastases

Scientists reveal molecular mechanism that increases the invasiveness of radioresistant cancer cells

Myeloid cell can suppress the immune response to tumor cells

RNA-centric mechanism regulates microRNAs linked to cancer, neurological disorders

Researchers use new technique to find undetectable ‘hot spots’ inside aggressive breast cancer

Researchers discover new ways to block the colonization and spread of tumor cells

Researchers identify new potential therapeutic targets for SARS-CoV-2 infection

Researchers identify a promising target for treating chemo-resistant cancer cells

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