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Researchers look for mechanisms that stabilize or destabilize key sections of biomolecules

Knowing precisely where proteins are frustrated could go a long way toward making better drugs. That's one result of a new study by Rice University scientists looking for the mechanisms that stabilize or destabilize key sections of biomolecules.

24 Nov 2020

Study reveals genomic structures that allow SARS-CoV-2 virus to control the infection process

An international research alliance has visualized the RNA folding structures of the SARS-CoV-2 genome, for the first time.

23 Nov 2020

Research sheds light on T cell abnormality in critically ill COVID-19 patients

There is an idea within the coronavirus research field that there is some kind of T cell abnormality in critically ill COVID-19 patients, but specific details have not yet been clarified. To shed light on the problem, a research collaboration based in Kumamoto University (Japan) has performed a genetic analysis of T cells from lung tissue of COVID-19 patients.

23 Nov 2020

Scientists discover how abnormal proteins unleash latent toxicity in neurodegenerative diseases

Thanks to modern medicine, humans tend to live much longer than before. Unfortunately, this also opens a wider window to develop chronic diseases with late-onset, such as neurodegenerative diseases.

23 Nov 2020

Study shows how brain protein helps pancreatic cancer cells to survive

Researchers have discovered that a protein thought to only be involved in the development of neurons in the brain also plays a major role in the development and growth of pancreatic cancer.

19 Nov 2020

Tau protein in Alzheimer's disease looks different at every dementia stage

Research into Alzheimer's disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients' brain tissue, a pathological form of the tau protein contributes to propagating the disease in the brain.

19 Nov 2020

Novel DNA-based nanogel for targeted delivery of chemotherapeutics

Current chemotherapy regimens slow cancer progression and save lives, but these powerful drugs affect both healthy and cancerous cells.

19 Nov 2020

Study shows CRISPR/Cas9 system can effectively treat metastatic cancers

Researchers have shown that the advanced CRISPR/Cas9 system is extremely effective in curing metastatic cancers.

19 Nov 2020

Gold nanoparticles put spotlight on small drug molecules in live cells

Successful drug development has a significant impact on people's quality of life worldwide. Being able to track how molecules get into target cells, and observing what they do when they are inside, is key to identifying the best candidates.

From Osaka University 19 Nov 2020

New protein imaging technique may lead to advanced tissue analysis

Researchers have defined a new protein imaging technique that may result in novel discoveries in disease, cell analysis, biological tissue, and more.

18 Nov 2020

Several hepatitis C drugs can inhibit the SARS-CoV-2 main protease

Scientists have determined that drugs meant for treating hepatitis C can block SARS-CoV-2 main protease, which allows reproduction in the novel coronavirus.

17 Nov 2020

Discovery of 'Achilles heel' in protein crucial to HIV virulence paves way for new drugs

The discovery of a potential "Achilles heel" in Nef, the protein that is crucial to HIV virulence and its capacity to trigger AIDS, paves the way for the development of a new class of drugs against the virus.

17 Nov 2020

New platform launched to push forward with antibiotic research and discovery

A network established by staff at the University of Plymouth has launched a new platform to push forward with worldwide antibiotic research and discovery.

17 Nov 2020

MIT chemists determine molecular structure of SARS-CoV-2 protein

MIT chemists have determined the molecular structure of a protein found in the SARS-CoV-2 virus. This protein, called the envelope protein E, forms a cation-selective channel and plays a key role in the virus's ability to replicate itself and stimulate the host cell's inflammation response.

From Massachusetts Institute of Technology (MIT) 16 Nov 2020