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Customized tumor cell vaccine produces active immune response in melanoma, neuroblastoma models

A pre-clinical study for melanoma and neuroblastoma shows that a customized tumor cell vaccine technique that targets Myc oncogenes coupled with checkpoint therapy produces an active immune response that bypasses antigen selection and immune privilege.

5 Apr 2021

Discovering a new genetic mutation in Schizophrenia

A new genetic mutation has been discovered in schizophrenia, and we spoke to Dr. Todd Lencz from the Feinstein Institutes for Medical Research to find out more.

From Northwell Health 1 Apr 2021

Key protein could block the most common cause of food poisoning

Scientists have identified a protein that could be crucial for inhibiting the most common human food poisoning, caused by bacteria, in the United States.

1 Apr 2021

Targeting epigenetic mechanisms to advance pharmacological treatments for alcoholism

Abusive alcohol drinking considerably impacts human health. Alcoholism, better defined as Alcohol Use Disorders (AUD), includes a group of pathological entities related to alcohol-induced damage.

1 Apr 2021

Simple 'designer' pore reproduces selective cellular transport mechanisms

The nucleus is the headquarters of a cell and molecules constantly move across the nuclear membrane through pores. The transport of these molecules is both selective and fast; some 1,000 molecules per second can move in or out.

31 Mar 2021

AI-based software for automatic tracking of cells in microscope videos

In modern basic life science research as well as in drug discovery, recording and analyzing the images of cells over time using 3D microscopy has become extremely important.

31 Mar 2021

Experimental antibody therapies for neurodegenerative diseases may lead to brain inflammation

A research team has made a novel finding that indicates that experimental antibody treatments for Alzheimer’s disease have an accidental adverse impact.

31 Mar 2021

Plants use signaling molecule to regulate their water balance

During drought conditions, plants utilize a signaling molecule known from animals to reduce their water loss.

31 Mar 2021

Six novel CRISPR-Cas12a variants expand genome engineering in plants

Yiping Qi continues to create new genome editing and engineering in plants, with the ultimate objective of enhancing the efficiency of food production.

31 Mar 2021

Strong cell-cell junctions preserve the quiescent properties of stem cells

The skin is known to be the largest organ in the human body, and its outermost layer, called the epidermis, is renewed every three weeks.

29 Mar 2021

Key molecule determines the pathogenesis of lupus

A new research work, published in JCI, has discovered that the endoplasmic reticulum of a neutrophil becomes stressed in the autoimmune disorder lupus.

29 Mar 2021

Specific protein helps insect-eating plants trap their prey

A Venus flytrap will shut immediately just at the brush of an insect’s wing.

26 Mar 2021

New genetic evidence points to novel therapies for “silent” stroke

According to a study, researchers have discovered new genetic clues in individuals who had experienced small but often apparently “silent” strokes.

26 Mar 2021

Researchers use mathematical modeling to explain CAR T-cell therapy dynamics

Chimeric antigen receptor T-cell therapy, or CAR T, is a relatively new type of therapy approved to treat several types of aggressive B cell leukemias and lymphomas.

26 Mar 2021

Silencing a key protein to “domesticate” COVID-19 virus

When cells in the human body are invaded by a virus, they send a signal to adjacent cells to boost their antiviral defenses to stop the spread of infection.

25 Mar 2021

New function of BMI1 gene can protect against Alzheimer’s disease

The Maisonneuve-Rosemont Hospital Research Centre has taken another step toward interpreting Alzheimer’s disease.

24 Mar 2021

Disease-driving B cells play a role in non-alcoholic fatty liver disease

A study by researchers proposes that disease-driving B cells—a kind of white blood cell—have a role in the development of non-alcoholic fatty liver disease.

23 Mar 2021

Bacteria residing within tumor cells may boost cancer immunotherapy

Cancer immunotherapy may get a boost from an unexpected direction: bacteria residing within tumor cells. In a new study published in Nature, researchers at the Weizmann Institute of Science and their collaborators have discovered that the immune system "sees" these bacteria and shown they can be harnessed to provoke an immune reaction against the tumor.

23 Mar 2021

Study advances CAR T cell therapy targeted at cancer

Cancer immunotherapy involves the activation of cells in the patient’s own immune system to fight tumor cells.

19 Mar 2021

New high-throughput system for testing drug candidates to treat neurodegenerative diseases

On the basis of a license agreement with the German Center for Neurodegenerative Diseases (DZNE) and the Leibniz Institute of Polymer Research Dresden (IPF), the Dresden-based start-up "Neuron-D GmbH" is developing a high-throughput system for testing drug candidates to treat neurodegenerative diseases.

19 Mar 2021