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How an obesity gene influences brain function

A complex condition, obesity is brought on by a confluence of factors including behavior, diet, and heredity. Getting enough food to survive and thrive was a challenge for millennia.

16 Jul 2024

Harnessing Enzymes for Making RNA Therapeutics

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and amyloidosis.

15 Jul 2024

Macrophage Inflammation may Contribute to LSD Symptoms

Researchers at The Hospital for Sick Children (SickKids) have found that inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions called lysosomal storage diseases (LSDs).

15 Jul 2024

Surface Plasmon Resonance Sensors: Transforming Drug Development and Clinical Diagnostics

The latest developments in SPR-based biosensors and their applications in drug discovery.

15 Jul 2024

Scripps Research Unveils Brain Neurons That Control First Bite and Drinking Behavior

Do you grab a fork and take a first bite of cake, or say no and walk away? Our motivation to eat is driven by a complex web of cells in the brain that use signals from within the body, as well as sensory information about the food in front of us, to determine our behaviors.

12 Jul 2024

Artificial Intelligence Drives Breakthroughs in Drug Discovery, Reducing Costs and Timelines

Researchers discussed using deep generative AI models and their diverse algorithms in de novo drug design.

12 Jul 2024

Liver-on-Chips: Innovations, Applications, and Challenges in Drug Development

The development and application of liver-on-chips and the factors preventing its widespread use in drug discovery.

12 Jul 2024

Key Brain Cells Discovered in Delaying First Bite of Food

Scientists at Scripps Research have pinpointed a group of neurons in the previously overlooked parasubthalamic nucleus (PSTN) that govern the initiation of feeding behavior.

11 Jul 2024

New Insights into ILC2 Development Could Lead to Innovative Therapies for Allergic Diseases

Scientists have discovered a novel mechanism of ILC2 immune cell development which may be involved in exacerbating allergic diseases.

11 Jul 2024

New Genetic Circuit Forces Cancer Cells to Self-Destruct

Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind.

5 Jul 2024

Bowel Cancer Cells Use Genetic On-Off Switch' to Evade the Immune System

Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that's been observed for the first time by researchers at UCL and University Medical Center Utrecht.

4 Jul 2024

Small Molecules Offer Precise Control Over Splicing in Gene Expression

The correct functioning of cells relies heavily on the ability to finely control gene expression, a complex process by which the information contained in DNA is copied into RNA to eventually give rise to all the proteins and most of the regulatory molecules in the cell.

3 Jul 2024