Acute Kidney Injury News and Research

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Acute kidney injury (AKI) involves sudden damage to the kidneys or decrease in renal function that occurs over a few hours or days. The severity of the condition can vary from a minor loss of kidney function to kidney failure.

Macrophage-Specific MAFB Deficiency Leads to Poor Prognosis in Acute Kidney Injury

Acute kidney injury (AKI) is associated with a poor prognosis, and no effective treatment has been established to date. Understanding the mechanisms that prevent the progression of AKI is crucial. In AKI, immune cells known as macrophages produce lipid mediators (LMs), which are lipids with significant physiological activity and play a pivotal role in promoting and suppressing inflammation. Thus, elucidating their function is of paramount importance.

30 Sep 2024

Study Reveals How Damaged Cells Contribute to Chronic Kidney Disease Progression

A study published in Nature Communications provides new insight into how damaged cells interact within disease-promoting microenvironments following acute kidney injury, or AKI.

6 Sep 2024

Study Unveils Dual Role of 7-DHC in Ferroptosis and Cancer Cell Survival

Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer's disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation.

2 Feb 2024

Genetic Variants of TNFAIP3 May Protect the Kidneys from Damage

A breakthrough in gene variants of an inflammation “brake” brings researchers one step closer to developing personalized treatments for those at risk of kidney disease and kidney failure.

26 Apr 2023