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Breakthrough Delivery System Advances CRISPR-Based Treatments

A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before.

10 Apr 2025

Circular RNA's Transformative Role in Tumor Biology and Treatment

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both a key player in tumor biology and a promising avenue for future therapies.

10 Mar 2025

Investigating Ubiquitination's Role in Cancer Stem Cell Regulation

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, recurrence, and drug resistance.

10 Mar 2025

New Computational Approach Speeds Up Genetic Variant Analysis for Disease Risk

Argonne computer scientists enabled a new research modality in the search for causality among genetic variants for a given disease.

18 Feb 2025

Genetic Editing Reveals Key Functions of Bean Plant Genes in Nitrogen Fixation

Beans are a key food at the dietary level, boasting high nutritional value and constituting the most directly consumed legume.

8 Feb 2025

EpiBERT AI Model Reveals How Genes Are Regulated in Human Cells

A team of investigators from Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard, Google, and Columbia University have created an artificial intelligence model that can predict which genes are expressed in any type of human cell.

30 Jan 2025

Compound from Sea Sponge Could be Used as a Chemical Probe for Research

Girolline, a compound extracted from the sea sponge Pseudaxinyssa cantharella, has been investigated for possible antitumor effects and also found to have anti-malarial effects.

15 Jan 2025

Unrepaired DNA Damage Can Persist for Years and Lead to Cancer Mutations

While most known types of DNA damage are fixed by our cells’ in-house repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that the damage has multiple chances to generate harmful mutations, which can lead to cancer.

15 Jan 2025

Advancing Sequential DNA Computing for Programmable Devices

DNA stores the instructions for life and, along with enzymes and other molecules, computes everything from hair color to risk of developing diseases.

13 Dec 2024

Scientists Unravel the Mystery of Gene Expression Bursting

Researchers at Kyushu University have discovered a connection between bursts of gene activity and the spatial distance between particular DNA regions.

9 Dec 2024

New Discovery Reveals Unintended Genetic Damage in CRISPR-Cas9 Therapy

Genome editing with various CRISPR-Cas molecule complexes has progressed rapidly in recent years.

5 Dec 2024

Genetic Study Reveals Vulnerability of Bonobos

Bonobos, endangered great apes that are among our closest relatives, might be more vulnerable than previously understood, finds a genetics study led by a UCL researcher that reveals three distinct populations.

17 Oct 2024

Scientists Identify Drug-Binding Site on FOXA1

Forkhead box protein 1 (FOXA1) is a difficult-to-target protein that is frequently involved in hormone-driven malignancies, such as those of the breast and prostate.

16 Oct 2024

Ribose-Water Interactions Stabilize RNA Structures

Ribonucleic acid (RNA) is a biological molecule that plays an important part in organismal genetics as well as the creation and development of life.

11 Sep 2024

Two Genes Control Explosive Taste Bud Growth in Cavefish

Over thousands of years, cavefish evolved and lost their vision, earning the moniker "the blind cavefish," but some cavefish also developed an inordinate number of taste buds on the head and chin.

16 Aug 2024

New Tool IMPRINT Enhances DNA Transformation in Various Bacterial Strains

Bacteria, with their unique capabilities, hold immense promise for improving various aspects of the world.

27 Jun 2024

Researchers Advance Single-Molecule DNA Sequencing Techniques

In recent years, technologies that allow scientists to investigate a person's DNA at single-molecule resolution have greatly increased the knowledge of the human genome, microbiome, and the genetic basis of disease.

5 Jun 2024

Protein SRSF1 Plays Unexpected Role in Unwinding Complex RNA Structures

RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence.

31 May 2024

Multiplexed Orthogonal Base Editors for Precise Mutation Modeling

The human genome consists of around 3 billion base pairs and humans are all 99.6% identical in their genetic makeup.

23 May 2024

Study Reveals the Surprising Role of Spliceosomes in Introns' Journey

Although you may not appreciate them, or have even heard of them, throughout your body, countless microscopic machines called spliceosomes are hard at work.

13 May 2024