Bryostatin is a macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin-1 binds to and inhibits the cell-signaling enzyme protein kinase C, resulting in the inhibition of tumor cell proliferation, the promotion of tumor cell differentiation, and the induction of tumor cell apoptosis. This agent may act synergistically with other chemotherapeutic agents.
Stanford University chemist Paul Wender and his colleagues are working to improve treatments for cancer, HIV and Alzheimer's - and they are betting that a drab, weedy marine invertebrate is the means to achieving that end.
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