Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 1, one copy inherited from each parent, form one of the pairs. Chromosome 1 is the largest human chromosome, spanning about 247 million base pairs (the building blocks of DNA) and representing approximately 8 percent of the total DNA in cells.
Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 1 likely contains more than 3,000 genes.
Genes on chromosome 1 are among the estimated 20,000 to 25,000 total genes in the human genome.
Mitochondrial diseases are among the most prevalent hereditary metabolic disorders, known to occur in one out every 5000 births.
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