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Study Shows How Genetic Variations Can Enhance Cancer Drug Effectiveness

By exploiting the genetic variation in cancer cells, an already approved cancer drug demonstrated enhanced effects against cancer cells in specific patient groups.

15 Nov 2024

Caterpillar Fungus Compound Blocks Cancer Growth Signals Within 30 Minutes

Cordycepin, derived from fungi, shows promise in cancer therapy by inhibiting growth factor signaling pathways critical for cell proliferation and survival.

15 Nov 2024

Bioengineered Yeast Achieves Breakthrough in Mass-Producing Herbal Medicine

Herbal medicine is difficult to produce on an industrial scale. A team of Kobe University bioengineers manipulated the cellular machinery in a species of yeast so that one such molecule can now be produced in a fermenter at unprecedented concentrations.

14 Nov 2024

C. elegans Model Revolutionizes Search for Amyloid Inhibitors

An international team led by researchers at the University of Toronto has developed an efficient and robust system, using the C. elegans nematode, to screen for compounds that can stop the growth of amyloid proteins.

29 Oct 2024

Study Reveals Role of Gut Microbes in Enhancing Children's Health

To address childhood malnutrition -; which affects 200 million children globally -; researchers at Washington University School of Medicine in St. Louis developed a therapeutic food that nourishes the collections of beneficial microbes that reside in the gut, and improves children's growth and other measures of their health.

25 Oct 2024

AI Model Predicts Active Ingredients with Dual Target Properties

Researchers from the University of Bonn have trained an AI process to predict potential active ingredients with special properties.

25 Oct 2024

African Wormwood Identified as Potential Weapon Against Drug-Resistant Tuberculosis

The mechanisms through which A. afra fights M. tuberculosis.

14 Oct 2024

New study reveals hidden diversity of acetic acid bacteria in the sourdough microbiome

Biologists have sequenced various acetic acid bacterial genomes to understand their genomic diversity, function, and ecology in the sourdough microbiome.

10 Oct 2024

Researchers Discover Key Genes for Plant Stress Tolerance

New research identifies for the first time the genes that help plants grow under stressful conditions - with implications for producing more sustainable food crops in the face of global climate change.

10 Oct 2024

Researchers Develop Highly Selective SARS-CoV-2 Mpro Inhibitors

New research from The Wistar Institute's Salvino lab -; led by professor Joseph Salvino, Ph.D. -; has identified a novel series of SARS-CoV-2 Mpro inhibitors that may lead to potential new COVID-19 treatments that, according to preclinical testing, effectively inhibits COVID-19 and synergizes with existing anti-COVID therapies.

9 Oct 2024

Fighting Drug-Resistant TB with a Novel Antibiotic

A novel semi-synthetic molecule that produces significant activity against strains of Mycobacterium tuberculosis, including those that are resistant to drugs, can be generated from natural compounds according to a study published in the American Society for Microbiology journal Microbiology Spectrum.

4 Oct 2024

High-throughput screening identifies potential drugs for low-grade serous ovarian cancer

In a recent study, researchers used high-throughput drug screening to identify potential therapeutic targets and novel treatments for low-grade serous ovarian cancer (LGSOC), offering hope for more effective and personalized therapies.

26 Sep 2024

Novel Tool Helps Identify Snake Venom Genes Across Species

Only about ten percent of the world's roughly 4,000 snake species have venom strong enough to seriously hurt a human, but that's enough for snake bites to be an important public health concern.

20 Sep 2024

Study Reveals Key Role of SAR11 Bacteria in Marine Nutrient Cycles

If you were to collect all the organisms from the ocean surface down to 200 meters, you'd find that SAR11 bacteria, though invisible to the naked eye, would make up a fifth of the total biomass.

12 Sep 2024

Fish Gut Bacteria May Hold the Key to New Skincare Ingredients

There are some pretty strange ingredients in cosmetics and skin care products. One example is snail mucin -; also known as snail slime -; which is used for its moisturizing and antioxidant properties.

6 Sep 2024

Arctic Actinobacteria Yield Novel Antivirulence Compounds Against E. coli

A novel set of techniques was created by researchers in Finland and Norway to screen unknown substances with bacterial origin for antivirulence activity.

2 Sep 2024

New Screening Methods Uncover Antivirulence Compounds from Arctic Actinobacteria

Antibiotics are the linchpin of modern medicine: without them, anyone with open wounds or needing to undergo surgery would be at constant risk of dangerous infections.

27 Aug 2024

Engineering Cyanobacteria-Yeast Systems for Synthetic Biology

Using evolution as a guiding principle, researchers have successfully engineered bacteria-yeast hybrids to perform photosynthetic carbon assimilation, generate cellular energy and support yeast growth without traditional carbon feedstocks like glucose or glycerol.

27 Aug 2024

Novel Drug Targets in Gardnerella Vaginalis: A Bioinformatics Approach to Combat Bacterial Vaginosis

A computational approach to identify proteins in G. vaginalis that could be potential drug targets.

20 Aug 2024

Enhanced Drug Discovery with Novel Sulfur Fluoride Exchange Reagent

Researchers at the Moffitt Cancer Center have created a new reagent that improves drug production precision. This novel approach, described in Nature Communications, presents a new sulfur fluoride exchange (SuFEx) reagent that enables the highly regulated manufacture of important sulfur-based compounds such as sulfinamides, sulfonimidamides, and sulfoximines.

19 Aug 2024