Embryonic Stem Cells News and Research

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Transposable Elements Drive a Critical Transition in Early Embryogenesis

Researchers at Sinai Health have discovered that DNA elements known as transposons, which may travel throughout the genome, control a crucial stage in early human development instead of human genes.

16 Oct 2024

Transposable Elements Are Key to Normal Progression of Embryonic Cells

A critical transition in early human development is regulated not by our own genes, but by DNA elements called transposons that can move around the genome, Sinai Health researchers have found.

16 Oct 2024

Human Stem Cell-Derived Retinal Organoid Sheets Close Macular Holes

Researchers reported in the journal Stem Cell Reports that retinal holes in a monkey model were successfully healed by transplanting human stem cells. Following transplantation, retinal tissue was continuously added to the macular holes to seal them.

4 Oct 2024

From Bone Regeneration to Heart Repair: Stem Cell Transplantation Paves the Way for New Medical Frontiers

Stem cell transplantation offers promising solutions for tissue regeneration and age-related degeneration, despite challenges in safety and production costs.

9 Sep 2024

Decoding Chromatin Modifications: A Breakthrough in Epigenome Editing

An epigenome editing platform and a method to program nine major chromatin modifications.

14 May 2024

Investigating Enhancer Function in Pluripotent Stem Cells

As embryos, all complex organisms are partially made up of pluripotent stem cells, a term for cells that have the capacity to differentiate into any kind of cell: nerve cells, muscle cells, blood cells, skin cells, and the like.

30 Apr 2024

USC Scientists Discover Protein Key to 3D Genome Control and Gene Silencing

Each cell’s nucleus contains DNA, which is the blueprint for human life.

17 Jan 2024

Japanese Scientists Revolutionize Regenerative Lung Medicine

Globally, chronic obstructive pulmonary disease, or COPD, is the third most common cause of mortality. It is characterized by permanent and irreversible lung damage, for which lung transplantation is the only effective treatment. Unfortunately, it is hard to find good lung donors.

8 Jan 2024

Wilmot Researchers Uncover a "Genomic Tug of War" That Influences Decitabine's Effectiveness

Some patients with myelodysplastic syndromes, like acute myeloid leukemia, benefit from a chemotherapy drug called decitabine that stunts cancer growth. But many others are resistant to decatibine's effects or become resistant over time.

17 Nov 2023

DNA Aptamer Promotes Cardiomyocyte Differentiation From Pluripotent Stem Cells

Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine.

12 Oct 2023

Towards A Better Understanding of Early Human Embryonic Development

Despite being an essential developmental process, the understanding of human embryonic genome activation is limited, owing to the lack of in vitro cell models and ethical concerns.

22 Sep 2023

How Scientists are Using iPSCs to Develop New Therapies

In 1998, scientists reported being able to derive cells from human embryos that could develop into almost any cell in the body. In 2007, the field took a huge leap when scientists discovered they could reprogram human adult skin cells to act like these embryonic stem cells.

20 Sep 2023