Exons News and Research

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A Novel Regulator of RNA Processing in Alzheimer's Disease

A research team from the University of Barcelona's Institute of Neurosciences described a novel molecular mechanism that modifies the process of protein synthesis and impacts RNA processing in Alzheimer's patients' brains.

21 Oct 2024

New Insights into U1 Snrnp Functions in Plant Splicing Mechanisms Using Arabidopsis

U1 snRNP interactions in Arabidopsis highlight its dual role in splicing and mRNA regulation, essential for maintaining transcript integrity and growth.

2 Oct 2024

Researchers Uncover Hundreds of New Potential Cancer Driver Genes

Researchers at the Centre for Genomic Regulation (CRG) have discovered hundreds of potential new cancer driver genes.

4 Sep 2024

Unveiling the Role of Exons in Protein Foldability and Evolution

A new study led by Rice University's Peter Wolynes offers new insights into the evolution of foldable proteins. The research was published in the Proceedings of the National Academy of Sciences.

4 Jul 2024

CRISPR-Derived Protein Controls Exon Inclusion and Exclusion

The University of Toronto researchers have successfully and precisely controlled the process of RNA splicing by using CRISPR, a bacterial immune defense system.

25 Jun 2024

Study Reveals the Surprising Role of Spliceosomes in Introns' Journey

Although you may not appreciate them, or have even heard of them, throughout your body, countless microscopic machines called spliceosomes are hard at work.

13 May 2024

New Biomarker Offers Early Detection of ALS and FTD

Two progressively degenerative diseases, amyotrophic lateral sclerosis (ALS, commonly known as Lou Gehrig's disease) and frontotemporal dementia (FTD, recently in the news with the diagnoses of actor Bruce Willis and talk show host Wendy Williams), are linked by more than the fact that they both damage nerve cells critical to normal functioning -; the former affecting nerves in the brain and spinal cord leading to loss of movement, the latter eroding the brain regions controlling personality, behavior and language.

19 Mar 2024

Study Reveals Genetic Mechanism Behind Human Tail Loss

A genetic change in our ancient ancestors may partly explain why humans don't have tails like monkeys, finds a new study led by researchers at NYU Grossman School of Medicine.

29 Feb 2024

Researchers Reveal Evolutionary Origin of Mysterious Immune System Molecule in Humans

Biological systems can behave as siblings in several ways, including by borrowing something and never giving it back.

31 Jan 2024

Gene Splicing Affects CD20 Expression and Response to Cancer Immunotherapy

Immunotherapies that target the CD20 antigen have revolutionized how patients with a variety of blood cancers and hematologic disorders have been treated.

17 Nov 2023

The Role of CRISPR-Cas9 in Treating Primary Immunodeficiency Disorders

Severe Combined Immunodeficiencies (SCIDs) encompass a collection of serious primary immunodeficiency disorders primarily instigated by genetic mutations that disrupt the development of T-cells.

30 Oct 2023

Novel Replacement Strategy Opens the Door to Therapeutic Interventions for Genomic Diseases

Severe Combined Immunodeficiencies (SCIDs) are a group of debilitating primary immunodeficiency disorders, primarily caused by genetic mutations that disrupt T-cell development.

27 Oct 2023

Disclosing the Key Role of Mitofusin 2 Cellular Makeup in Interconnecting Organelles Within Cells

Researchers at IRB Barcelona, the University of Barcelona (UB), VIMM, and the University of Padua unveil the key role of Mitofusin 2 cellular makeup in interconnecting organelles within cells.

29 Jun 2023

New Genetic Mutations Linked to Canine Bladder Cancers Identified

Researchers have identified new genetic mutations linked to a subset of canine bladder cancers. Their findings have implications both for early cancer detection and for targeted treatments in dogs and humans.

26 Apr 2023

Pancreatic islet microexons play key role in islet function and glucose homeostasis

When cells copy DNA to produce RNA transcripts, they include only some chunks of genetic material known as exons and throw out the rest.

10 Feb 2023

New tool advances potential means to deliver gene therapy

Researchers from Johns Hopkins Medicine claim to have successfully “slid” genetic instructions into a cell and produced essential proteins that were lacking from those cells using a cell’s normal process for creating proteins.

1 Nov 2022

NATA accreditation for BGI Australia to perform whole exome sequencing

The National Association of Testing Authorities (NATA) has accredited BGI Australia’s lab to conduct clinical Whole Exome Sequencing in Australia, opening the door for the multinational life sciences company to offer clinical sequencing services for locating potential disease-causing genetic changes.

25 Oct 2022

New computer model helps identify mutations that drive tumor growth

Cancer cells can have thousands of mutations in their DNA. However, only a handful of those actually drive the progression of cancer; the rest are just along for the ride.

22 Jun 2022

Novel molecular pathway shared by ALS and frontotemporal dementia identified

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia.

1 Mar 2022

Researchers identify a novel pathomechanism leading to Usher syndrome

Human Usher syndrome (USH) is the most common form of hereditary deaf-blindness. Sufferers can be deaf from birth, suffer from balance disorders, and eventually lose their eyesight as the disease progresses.

12 Jul 2021