Gene Silencing News and Research

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RNA Interference Drugs Offer Faster, More Effective Alternative to Traditional Drug Discovery

Alnylam's RNA interference platform accelerates drug discovery by targeting RNA transcripts, addressing complex diseases with innovative therapeutic strategies.

28 Aug 2024

Study Reveals Mechanisms Behind Lineage Restriction in Cell Development

A team of researchers from multiple institutions including the University of Chicago and VectorBuilder, has made a significant breakthrough in the understanding of lineage restriction, a biological phenomenon foundational to multicellular lifeforms as it secures the functional identities of the myriad cell types in the body.

14 Aug 2024

CRISPR-Cas: A Promising Tool For Combatting Antibiotic-Resistant Staphylococcus aureus

Using CRISPR-Cas systems in various studies to detect and treat Staphylococcus aureus.

12 Aug 2024

Novel Epigenetic Tool CHARM Offers Hope for Prion Disease Treatment

In a new study in mice, researchers introduce "CHARM," a compact and versatile epigenetic editor that can be used to silence prion protein throughout the brain.

28 Jun 2024

New Chemical Modification Enhances Antisense Oligonucleotide Targeting in CNS Diseases

Diseases that affect the brain and spinal cord can be particularly devastating, and finding new and more effective ways to treat these conditions is an important goal for researchers and clinicians alike.

23 May 2024

USC Scientists Discover Protein Key to 3D Genome Control and Gene Silencing

Each cell’s nucleus contains DNA, which is the blueprint for human life.

17 Jan 2024

Berkeley Lab and Genentech Team Up to Develop Next-Generation Drug Delivery System

Many diseases can be successfully treated in the simple environment of a cell culture dish, but to successfully treat real people, the drug agent has to take a journey through the infinitely more complex environment within our bodies and arrive, intact, inside the affected cells.

18 Jul 2023

Breakthrough "Gene Silencing" Technology Could Revolutionize the Development of DNAzymes

Researchers from the University of California, Irvine have developed a DNA enzyme – or DNAzyme – that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact.

9 May 2023

A Study on Gene Silencing Through a Recent Trial

Dr Catherine Mummery, a consultant neurologist at UCL Queen Square Institute of Neurology & the National Hospital for Neurology and Neurosurgery, has led a trial. The trial signifies for the first time that a “gene silencing” method has been taken in Alzheimer’s and dementia disease.

From University College London 27 Apr 2023

Gene-Silencing Complexes Work Together to Render X Chromosomes Inactive

Two protein complexes are involved in the mysterious process of shutting off one X chromosome in female mammals, according to a new study from RIKEN. This result could aid in the understanding of how specific tumors in women develop.

21 Apr 2023

Molecular Mechanisms That Maintain the Tissue Specificity of PKMzeta

The protein PKMzeta has been strongly associated with long-term memory formation.

19 Apr 2023

Effective and faster methodology detects RNA viruses based on the triplex-forming probe technology

Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), the Institute of Microelectronics of Barcelona (IMB-CNM-CSIC) and the Aragon Nanoscience and Materials Institute of Aragon (INMA) -;a joint institute of the CSIC and the University of Zaragoza-; have developed a new method to detect RNA viruses based on the triplex-forming probe technology.

28 Feb 2023

Researchers discover target enzyme for blast disease

A fungus that plagues rice crops worldwide gains entry to plant cells in a way that leaves it vulnerable to simple chemical blockers, a discovery that could lead to new fungicides to reduce the substantial annual losses of rice and other valuable cereals.

14 Feb 2023

Research reveals how RNA elements control cleavage activity of DICER enzyme in pre-miRNA and shRNAs

A research team led by scientists from the Hong Kong University of Science and Technology has revealed how secondary structure RNA elements control the cleavage activity of the DICER enzyme in both pre-miRNA and short-hairpin RNAs, improving the understanding of the DICER cleavage mechanism and providing a foundation for the design of accurate and efficient short-hairpin RNAs for gene-silencing.

20 Apr 2022

Gene Silencing News and Research

RNA Interference Drugs Offer Faster, More Effective Alternative to Traditional Drug Discovery

Study Reveals Mechanisms Behind Lineage Restriction in Cell Development

CRISPR-Cas: A Promising Tool For Combatting Antibiotic-Resistant Staphylococcus aureus

Novel Epigenetic Tool CHARM Offers Hope for Prion Disease Treatment

New Chemical Modification Enhances Antisense Oligonucleotide Targeting in CNS Diseases

USC Scientists Discover Protein Key to 3D Genome Control and Gene Silencing

Berkeley Lab and Genentech Team Up to Develop Next-Generation Drug Delivery System

Breakthrough "Gene Silencing" Technology Could Revolutionize the Development of DNAzymes

A Study on Gene Silencing Through a Recent Trial

Gene-Silencing Complexes Work Together to Render X Chromosomes Inactive

Molecular Mechanisms That Maintain the Tissue Specificity of PKMzeta

Effective and faster methodology detects RNA viruses based on the triplex-forming probe technology

Researchers discover target enzyme for blast disease

Research reveals how RNA elements control cleavage activity of DICER enzyme in pre-miRNA and shRNAs

Researchers discover how an “accordion effect” is vital for switching off genes

Experimental "gene silencing" therapy reduces a important driver of heart disease risk by up to 98%

HDO technology found to be effective at silencing problematic genes

Study findings likely to be instrumental in synthetic biology approaches

Epigenetic inheritance enhances mating in stressed out C. elegans

Research focuses on how short-term genetic memories can be inherited across generations

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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