Glycan News and Research

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New Insights into the Mechanism of Glycan Branch Formation

Glycans are sugar chains that bind to cells via proteins or lipids, altering their chemical properties

30 Oct 2024

Recombinant Expression and Glycosylation of EBN Mucin

The first recombinant mucin protein obtained from the Edible-nest Swiftlet Aerodramus fuciphagus (AfMuc) has been successfully identified and synthesized by a research team.

21 Oct 2024

Glycosylation and its Role in Human Health and Disease

The current understanding of glycosylation genetics in mammals and the consequences of mutations that impact glycosylation.

16 May 2024

Live-Cell Imaging Reveals How STING Activates Innate Immunity

When pathogens attack the body, the innate immune system goes to work protecting against the invading disease.

12 Jan 2024

Scientists Develop Novel Glycoengineering Platform to Revolutionize Vaccine and Therapeutic Production

A novel glycoengineering platform, created by the laboratory of Assistant Professor Chris Lok-To Sham from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), is poised to revolutionize future production of vaccines and therapeutics to fight infectious diseases.

17 Oct 2023

New Automated Machine Learning Tool to Design and Interpret Biological Sequences

The amount of data generated by scientists today is massive, thanks to the falling costs of sequencing technology and the increasing amount of available computing power.

22 Jun 2023

Novel Gene-Editing Strategy Harnesses Unusual Protective Ability to Eliminate HIV-1 Infection

Genetic alterations that give rise to a rare, fatal disorder known as MOGS-CDG paradoxically also protect cells against infection by viruses.

22 May 2023

Novel 3D Structure can Serve as Blueprint to Engineer New BoNT/E Variants

A team of researchers from the University of California, Irvine, have revealed the first crystal structures of the receptor-binding domain of botulinum neurotoxin E (BoNT/E) in complex with its human neuronal receptors, synaptic vesicle glycoprotein 2A (SV2A).

28 Apr 2023

New antibody "cocktail" may help counter the Lassa virus

The finding, made with the use of the Advanced Photon Source, shows a new way to exploit monoclonal antibodies to subvert the "shield" of the virus, potentially paving the way for new therapies.

20 Mar 2023

Potential SARS-CoV-2 therapy based on banana protein

A study praising the development of a potential treatment that might be applied to combat all recognized influenza strains was published online on January 13th, 2020.

25 Oct 2022

Study shows how gut bacteria feed on carbohydrate attached to plant proteins

A carbohydrate commonly found attached to plant proteins is a food source for the bacteria in our gut, new research suggests.

23 Sep 2022

Researchers find why SARS-CoV-2 does not spread easily from surfaces

Early in the pandemic, many people fastidiously disinfected surfaces because laboratory studies predicted that SARS-CoV-2 could be easily transmitted in this way.

3 Mar 2022

SARS-CoV-2 spike protein can specifically recognize the terminal sialic acid on sugars

The virus causing the current COVID-19 pandemic is the SARS-CoV-2. Soon after the pandemic outbreak in 2019, the ACE-2 protein, which is present on some of our cells´ surface, was identified as the receptor facilitating host cell viral entry.

3 Mar 2022

Researchers develop a simple and effective strategy to synthesize site-specific antibody–drug conjugates

Antibody-drug conjugates, an intricate that covalently links a potent cytotoxin to an antibody, have piqued the interest of researchers as a new bio-therapeutic methodology.

14 Feb 2022

Research could help understand DCIR's role in the pathogenesis of autoimmune diseases

While dendritic cell immunoreceptor (DCIR) is known to mediate inflammation and bone metabolism, ligands that bind DCIR and the mechanisms underlying DCIR activity remain poorly understood.

From Tokyo University of Science 25 Nov 2021

Study employs AI to comprehend sugar surrounding proteins in the human body

Novel studies on artificial intelligence (AI) algorithms facilitated researchers to develop more complete models of the protein structures in human bodies.

8 Nov 2021

Study provides insights on mucin degradation mechanisms by a group of gut bacteria

Recent research identified that a single sulfatase adds to the degradation of mucus that safeguards the intestinal lining.

13 Oct 2021

Waters BioAccord System with ACQUITY Premier brings greater simplicity, accuracy and reproducibility to multi-attribute monitoring of biopharmaceuticals

Waters Corporation today introduced the Waters™ BioAccord™ System with ACQUITY™ Premier, a combination of the Waters BioAccord System and the breakthrough ACQUITY Premier UPLC™ with MaxPeak™ High Performance Surface technology.

From Waters Corporation 17 Sep 2021

Researchers discover how glycans act as gateways for SARS-CoV-2 entry

Since the early days of the COVID pandemic, scientists have aggressively pursued the secrets of the mechanisms that allow severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter and infect healthy human cells.

From UC San Diego 20 Aug 2021

AI model helps predict which viruses are likely to spread from animals to humans

A new model that applies artificial intelligence to carbohydrates improves the understanding of the infection process and could help predict which viruses are likely to spread from animals to humans. This is reported in a recent study led by researchers at the University of Gothenburg.

16 Jun 2021