Lymph Nodes News and Research

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Advanced Imaging Deciphers B Cell Dynamics in Lymph Nodes

Germinal centers are machines of rapid evolution. Germinal centers are tiny clusters in the lymph nodes that refine antibodies through proliferation and mutation to create high-affinity B cells that are suited to control various infections.

20 Mar 2025

Uncovering a New Mechanism in Immune Cell Regulation During Parasitic Infections

Researchers at the University of Liège (Belgium) have uncovered a previously unknown mechanism that regulates the immune response against parasites.

10 Feb 2025

Unveiling the Impact of Antigen History on CAR-T Cell Function

The memory of previous interactions with bacteria, viruses, and other antigens is carried by some CAR-T cells that have been engineered to fight cancer and other conditions, according to research from the University of Colorado Anschutz Medical Campus.

3 Jan 2025

Unveiling the Epigenetic Landscape of Blood Cancers

In recent years, biomedical laboratory research has undergone tremendous change, to the extent that computers have frequently replaced test tubes.

27 Nov 2024

Stem-Like CD4 T Cells Could Transform Cancer Treatment Strategies

Researchers at Winship Cancer Institute of Emory University have identified a novel type of immune cell, called the stem-like CD4 T cell, that plays a pivotal role in anti-tumor immunity.

28 Oct 2024

Multispecies Transmission of Avian Flu Virus Includes Dairy Cattle, Cats, and Raccoons

A viral spillover of the highly pathogenic avian influenza virus belonging to the hemagglutinin 5 neuraminidase 1 (H5N1) 2.3.4.4b clade among herds of dairy cattle.

5 Aug 2024

Scientists develop first fully functional human immune system in mouse model

Researchers at The University of Texas Health Science Center in San Antonio have produced a mouse model that is humanized, complete with a human immune system and a gut microbiome that resembles that of a human being and is able to elicit particular antibody responses.

8 Jul 2024

DNA Origami Revolutionizes Cancer Immunotherapy: The DoriVac Breakthrough

Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading.

15 Mar 2024

Researchers Unveil New Mechanism of Immune Cell Training in Thymus Gland

Immune cells must learn not to attack the body itself. A team of researchers from the Technical University of Munich (TUM) and the Ludwig Maximilian University of Munich (LMU) has discovered a previously unknown mechanism behind this: other immune cells, the B cells, contribute to the "training" of the T cells in the thymus gland.

22 Feb 2024

New CRISPR-Based Test Detects Mpox Faster

A rare viral illness called mpox, formerly known as monkeypox, is transmitted by direct physical contact between individuals.

12 Feb 2024

Trapped Inside Tumors: How Dendritic Cells Lose Their Anti-Tumor Abilities

According to new research, certain immune cells in human bodies experience a reduction in their "killer instinct" after entering solid tumors.

5 Feb 2024

Dendritic Cells Reprogram Their Genes to Enhance Immune Response

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), under the leadership of Professor Francisco Sánchez-Madrid, have discovered that dendritic cells, responsible for triggering targeted immune responses, possess the ability to modify their genes in order to enhance their immune reactivity.

6 Nov 2023

New Way to Visualize Tumors During Surgery

Surgeons often face the challenge of achieving precise tumor removal while preserving healthy tissue. Traditionally, they rely on their visual and tactile senses to determine where to make incisions.

17 Oct 2023

Immune Cells Can Create Their Own Chemical Cues to Navigate

In a breakthrough finding, Jonna Alanko, a researcher from InFLAMES, has unveiled that immune cells are not mere passive followers of chemical signals in their surroundings.

7 Sep 2023

High-Throughput Screening of Existing Drugs to Fight Multiple Myeloma More Effectively

Multiple myeloma is a rare blood cancer caused by the uncontrolled multiplication of abnormal plasma cells.

28 Apr 2023

Study Establishes Two Distinct Regulatory T Cell Populations

According to a recent study headed by the Children’s Hospital of Philadelphia (CHOP), a regulatory class of human T cells is descended from two distinct origins, one related to autoimmunity and one related to protective immunity.

10 Apr 2023

Keeping lymph nodes in the body can boost the efficacy of cancer immunotherapy

Cancer treatment routinely involves taking out lymph nodes near the tumor in case they contain metastatic cancer cells.

21 Mar 2023

Developing new therapies that leverage the host immune system

Yersinia bacteria cause a variety of human and animal diseases, the most notorious being the plague, caused by Yersinia pestis. A relative, Yersinia pseudotuberculosis, causes gastrointestinal illness and is less deadly but naturally infects both mice and humans, making it a useful model for studying its interactions with the immune system.

14 Mar 2023

Researchers track a specialized garbage disposal cell inside lymph nodes for the first time

For almost 140 years, the origin and behavior of an enigmatic cell type inside lymph nodes, called a tingible body macrophage, has remained a mystery.

3 Mar 2023

A protein in the lung forms a natural protective barrier against SARS-CoV-2 infection

University of Sydney scientists have discovered a protein in the lung that blocks SARS-CoV-2 infection and forms a natural protective barrier in the human body.

10 Feb 2023