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The Role of DNA Repair Pathways in Antibody Somatic Hypermutation

In a recent online publication in SCIENCE CHINA Life Sciences, researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine published a review article entitled "Molecular Mechanisms of DNA Lesion and Repair During Antibody Somatic Hypermutation". This review comprehensively summarizes the mechanisms involved in the generation of antigen-specific diversified antibodies, with a particular focus on the mechanisms that generate high-frequency point mutations and low-frequency deletions and insertions (indels) in antibody genes.

22 Aug 2024

AMSBIO's fully characterized and annotated FFPE tissue blocks can help streamline research projects

AMSBIO has established an unmatched commercial biorepository and procurement network that includes a large selection of fully characterized and annotated Formalin-Fixed Paraffin-Embedded (FFPE) tissue blocks to help streamline your research.

From AMS Biotechnology 1 Jul 2021

New technique boosts the efficacy of future malaria vaccines

A new technique for obtaining pure malaria parasites from infected mosquitos could speed up the development of novel, more powerful malaria vaccinations.

21 Jun 2021

New protocol identifies mismatch repair deficiency

Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of DNA in the colon, endometrial, and other cancers.

22 Jan 2021

MMR vaccine may be protective against COVID-19, study shows

The measles-mumps-rubella (MMR) vaccine has been theorized to provide protection against COVID-19. In a new study published in mBio, an open-access journal of the American Society for Microbiology, researchers provide further proof of this by showing that mumps IgG titers, or levels of IgG antibody, are inversely correlated with severity in recovered COVID-19 patients previously vaccinated with the MMR II vaccine produced by Merck. MMR II contains the Edmonston strain of measles, the Jeryl Lynn (B-level) strain of mumps, and the Wistar RA 27/3 strain of rubella.

23 Nov 2020

Study shows MMR vaccine may protect against COVID-19 symptoms

According to a group of experts, the administration of the MMR vaccine could act as a preventive measure to reduce inflammation linked to COVID-19 infection.

22 Jun 2020