Mammalian Cells News and Research

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African Wormwood Identified as Potential Weapon Against Drug-Resistant Tuberculosis

The mechanisms through which A. afra fights M. tuberculosis.

14 Oct 2024

Study Reveals Gene Linked to Cold Resistance in Hibernating Mammals

A gene that limits cellular damage could be the key to surviving prolonged cold exposure.

1 Oct 2024

Human Cells Exhibit Dormant State Similar to Embryonic Diapause

In some mammals, the timing of the normally continuous embryonic development can be altered to improve the chances of survival for both the embryo and the mother.

27 Sep 2024

New Gene Editing Tool Shows Promise for Treating Diseases

Bacterial and archaeal CRISPR-Cas systems, comprising protein and RNA components, were initially developed as a natural defense mechanism against invading viruses.

24 Sep 2024

PKN Inhibition Reduces Cardiac Fibrosis and Improves Heart Function

The number of people suffering from heart failure is rising quickly as society ages. Heart failure progression is linked to fibrosis, or the overgrowth of fibrotic tissue in the heart.

16 Sep 2024

Bacterial Protein Utilizes DNA for Target Recognition and Plasmid Elimination

Scientists who have described in a new study the step-by-step details of a bacterial defense strategy see the mechanism as a promising platform for development of a new genome-editing method.

30 Aug 2024

UChicago Team Secures $7.4 Million Grant to Study Cellular Adaptation

Cells use a variety of processes to adapt to changes and stressors in their environment, like increased temperature.

21 Aug 2024

Understanding the Molecular Basis of Avian Influenza Host Shift

A recent study by the Cusack group clarifies how a crucial enzyme of the avian influenza virus can change, enabling the virus to spread to mammals.

20 Aug 2024

New ProteoCHIP EVO 96 Boosts Single-Cell Proteomics Sensitivity and Throughput

A label-free single-cell proteomics workflow that integrated the automated sample handling, optimal ion usage, and high-throughput capacities.

18 Jul 2024

AI-Driven Design of Soluble Protein Analogs for Drug Discovery and Antibody Development

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

24 Jun 2024

Engineered Enzyme Boosts Gene Editing Efficiency for Potential Cystic Fibrosis Treatment

Researchers at the Broad Institute of MIT and Harvard have enhanced a gene-editing technology, enabling it to efficiently insert or substitute entire genes in the genome of human cells.

11 Jun 2024

Novel Lipopeptide from Serratia marcescens Shows Promise Against Staphylococcus aureus Infections

A novel antibacterial lipopeptide produced by the bacterium Serratia marcescens has been shown to be highly effective in killing Staphylococcus aureus – one of the most important pathogens occurring in humans.

7 Jun 2024

Efficient Gene Editing with Compact Cas12a Protein

Researchers have created an innovative version of a critical CRISPR gene-editing protein that has effective editing activity and is small enough to be bundled into a non-pathogenic virus capable of delivering it to targeted cells.

31 May 2024

Cryo-EM Study Reveals Cas7-11-CRISPR Complex Regulation Mechanisms

In a recent study published in Signal Transduction and Targeted Therapy, Chinese researchers studied the cryo-electron microscopy structures of the CRISPR-Cas7-11 nuclease, both alone and in complex with the regulatory protein tetratricopeptide repeat fused with Cas/(human enhancer of filamentation 1) HEF1-associated signal transducer (TPR-CHAT).

24 May 2024