Myeloperoxidase (MPO) is a peroxidase enzyme most abundantly present in neutrophil granulocytes (a subtype of white blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus.
An examination investigating the impact of hypochlorous acid (HOCl), commonly recognized as bleach, produced during a cell’s immune response (phagocytosis) combating the common fungal pathogen Candida albicans, reveals the potent lethality of HOCl.
Researchers at The University of Texas MD Anderson Cancer Center have developed a new radio-labeled molecule capable of selectively reacting with certain high-energy radicals that are characteristic of innate immune activity, which may allow a non-invasive approach to monitor inflammation in real time by positron emission tomography (PET) imaging.
Autoimmune disease is fundamentally a mystery: whyever should an organism systematically set out to harm itself? Now, researchers at the University of Tsukuba have identified a genetic basis for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, an autoimmune systemic disease that damages organs by targeting small blood vessels in a genetic association study.
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