Neurodegenerative Disease News and Research

RSS

Sodium Transport Found to Play a Surprising Role in Mitochondrial Energy Production

The GENOXPHOS (Functional Genetics of the Oxidative Phosphorylation System) group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has discovered a crucial role of sodium in the generation of cellular energy.

20 Sep 2024

The Complex Link Between DNA Modification and ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease which remains incurable. The disease is characterized by the selective degeneration of upper motor neurons in the motor cortex as well as the lower motor neurons in the brainstem and spinal cord. The cause of ALS remains unknown in 90 percent of cases, which are referred to as sporadic ALS because there is no family history for the disease. Cumulative evidence suggests that sporadic ALS may result from complex interactions between genetic susceptibility and aging.

23 Aug 2024

Deep-Learning Model Identifies Parkinson's Disease-Specific Neuroanatomical Features

A deep-learning-based contrastive approach to examine magnetic resonance imaging (MRI) scans from Parkinson’s disease patients.

14 Aug 2024

Noninvasive Ultrasound Method Enables Tracking of Gene Expression in Specific Brain Regions

The ability to alter or prevent the expression of faulty genes in the brain could be leveraged as a powerful therapeutic against neurodegenerative disease. However, the molecular underpinnings of the living brain are still largely inaccessible, hampering progress on such promising therapeutics.

9 Aug 2024

Researchers Capture Protein Tangle Formation in Real-Time

Protein tangles known as amyloid-beta (A-beta) aggregates are most famously linked to neurodegenerative illnesses like Alzheimer's. Nevertheless, despite its frequent attention, scientists have not been able to fully comprehend how A-beta assembles and disassembles.

22 Jul 2024

UCL Study Uncovers Astrocytes' Role in Brain Energy Boosting Mechanism

A key mechanism which detects when the brain needs an additional energy boost to support its activity has been identified in a study in mice and cells led by UCL scientists.

4 Jul 2024

Novel protein biomarker panel can detect Parkinson's disease in early stages using blood samples

A team of researchers used multiplexed mass spectrometry data and a machine learning model to identify biomarkers that can predict Parkinson’s disease.

27 Jun 2024

Modifying Cellular Interactions Near Amyloid Plaques May Offer New Alzheimer's Treatments

Researchers at Mount Sinai’s Icahn School of Medicine have achieved a big breakthrough in Alzheimer’s disease research by discovering a new technique to potentially slow or even stop disease development.

28 May 2024

Glutamate tRNA Fragments Play Key Role in Brain Aging and Alzheimer's Disease

A significant research paper published in the journal Cell Metabolism by the team of Prof. LIU Qiang at the University of Science and Technology of China (USTC) reveals the critical role of glutamate tRNA fragments in brain aging and Alzheimer's disease.

14 May 2024

Unveiling Mechanisms to Block Tau Aggregation

The buildup of aberrant, misfolded tau proteins in the brain is the cause of a variety of neurodegenerative illnesses, such as Fronto Temporal Dementia (FTD), Progressive Supranuclear Palsy (PSP), and Cortico Basal Degeneration (CBD).

4 Apr 2024

Unraveling the Mysteries of Neuronal Communication Circuits

The basic building blocks of the central nervous system are neurons, or nerve cells, which play a crucial role in signal transduction pathways.

3 Apr 2024

Study Investigates Links Between Gene Expression and Primate Brain Evolution

An interdisciplinary team of researchers led by biologists at the University of Massachusetts Amherst recently published the results of a first-of-its-kind study investigating the links between gene expression and brain evolution across 18 primate species.

1 Apr 2024

New Theory Links Gene Length to Cellular Decline

A gene’s length may have more to do with aging than particular “aging genes.” Reduced expression of long genes may be the cause of many aging-related changes, according to researchers writing an opinion piece that was published in the journal Trends in Genetics on March 21st, 2023.

25 Mar 2024

Unraveling the Role of Gene Length in Aging

Aging may be less about specific "aging genes" and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers in an opinion piece publishing March 21 in the journal Trends in Genetics.

22 Mar 2024

Astrocyte-Rich Brain Organoid Model Unveils Insights into Neuroinflammation

The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain.

1 Mar 2024

Uncovering How to Protect Nerves in Neurodegenerative Diseases

Researchers at the Case Western Reserve University School of Medicine have led a team that has discovered a novel therapeutic strategy for treating neurodegenerative illnesses, raising the prospect of better care for conditions like multiple sclerosis, Alzheimer's disease, Parkinson's disease, and Vanishing White Matter disease.

21 Feb 2024

Neurodegenerative Disease News and Research

Sodium Transport Found to Play a Surprising Role in Mitochondrial Energy Production

The Complex Link Between DNA Modification and ALS

Deep-Learning Model Identifies Parkinson's Disease-Specific Neuroanatomical Features

Noninvasive Ultrasound Method Enables Tracking of Gene Expression in Specific Brain Regions

Researchers Capture Protein Tangle Formation in Real-Time

UCL Study Uncovers Astrocytes' Role in Brain Energy Boosting Mechanism

Novel protein biomarker panel can detect Parkinson's disease in early stages using blood samples

Modifying Cellular Interactions Near Amyloid Plaques May Offer New Alzheimer's Treatments

Glutamate tRNA Fragments Play Key Role in Brain Aging and Alzheimer's Disease

Unveiling Mechanisms to Block Tau Aggregation

Unraveling the Mysteries of Neuronal Communication Circuits

Study Investigates Links Between Gene Expression and Primate Brain Evolution

New Theory Links Gene Length to Cellular Decline

Unraveling the Role of Gene Length in Aging

Astrocyte-Rich Brain Organoid Model Unveils Insights into Neuroinflammation

Uncovering How to Protect Nerves in Neurodegenerative Diseases

APOE4's Influence on Lipid Droplets in Brain Cells

Ancient DNA Reveals Reason for High Multiple Sclerosis and Alzheimer’s Rates in Europe

Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

Misfolded Proteins: How They Damage Neurons and Cause Neurodegeneration

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

Latest in Genomics