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3D Tumor Microenvironment Model Highlights Role of Ischemia and Acidification in Cancer Spread

Developed 3MIC model simulates tumor microenvironments, enabling direct observation of ischemic effects on cancer cell invasiveness and drug resistance.

4 Nov 2024

C. elegans Model Revolutionizes Search for Amyloid Inhibitors

An international team led by researchers at the University of Toronto has developed an efficient and robust system, using the C. elegans nematode, to screen for compounds that can stop the growth of amyloid proteins.

29 Oct 2024

New VitelloTag Method Revolutionizes Gene Editing in Egg Cells and Embryos

A new approach for delivering miniature research tools into the interior of egg cells and embryos has been developed at the Marine Biological Laboratory (MBL), resolving a major bottleneck to using the gene-editing tool CRISPR-Cas9 in many research organisms.

11 Sep 2024

Monoclonal Antibody SC27 Shows Broad Effectiveness Against SARS-CoV-2 Variants

A monoclonal antibody appears effective at neutralizing the numerous variants of SARS-CoV-2, as well as related viruses in animals that could pose a threat if they were to begin spreading in people.

10 Sep 2024

Mini-Gut Model Unlocks Secrets of COVID-19 Diarrhea

Researchers at Johns Hopkins Medicine claim to have identified multiple molecular pathways linked to diarrhea caused by COVID-19, offering possible therapeutic interventions utilizing human stem cells to create a sort of “mini intestine-in-a-dish.

7 Aug 2024

Innovative Model Creates Personalized Parkinson's Disease Brain Cells for Drug Testing

A new model developed by Brigham researchers rapidly converts stem cells to brain cells characteristic of Parkinson’s disease to create personalized stem cell models with opportunities to test treatments

29 Jul 2024

New High-Throughput Platform for Rapid Evaluation of Plant-Derived Molecules

Plants are powerhouses of molecular manufacturing. Over the eons, they have evolved to produce a plethora of small molecules -; some are beneficial and valuable to humans, others can be deadly.

28 Jun 2024

Genetic Influences on Lifespan Variance and Healthspan in Caenorhabditis elegans

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

25 Jun 2024

Understanding Collective Cell Behavior in Constrained Environments

Looking under the microscope, a group of cells slowly moves forward in a line, like a train on the tracks.

20 Jun 2024

Unlocking the Secrets of Childhood Cancer Genetics

Scientists have revealed a fresh insight into the genetic pathway of childhood cancer, providing new potential for personalized treatment.

15 May 2024

New Platform Reveals Individual Sensitivity to Disease-Causing Mutations

In humans, the exact same mutation in a specific gene can produce widely different outcomes. It's a bit like adding the same amount of salt to different recipes-;the effect on the finished dish can be quite different, depending on the mix of other ingredients.

4 Apr 2024

Investigating the Link Between Metabolism and Intestinal Development

Intestines can reach a length of 15 feet or more; how does it fit within human bodies properly? The gut tube dramatically loops and rotates to bundle the extending intestine as the digestive system grows. Intestinal malrotation is a common, but poorly understood, birth defect caused by the failure of the gut to rotate correctly during development.

20 Feb 2024