Pharmaceuticals News and Research

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Non-Active Site Mutations Drive Enzyme Adaptation to Low Temperatures

Enzymes initially developed in high-temperature environments and subsequently adapted to cooler conditions as the Earth underwent a cooling phase.

26 Mar 2025

Engineered Yeast Offers Sustainable Way to Produce D-Lactic Acid from Methanol

Great recipes require the perfect combination of ingredients - biotechnology recipes are no exception.

22 Mar 2025

Researchers Develop RNA "Barcoding" Tool to Track Genetic Exchange in Bacteria

In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive antibiotic resistance and even shape entire ecosystems.

19 Mar 2025

Phytogene Offers a Greener, Cheaper Alternative for Producing Pharmaceuticals

To tackle the inequity in medication access, a societal issue especially in developing nations, a team of undergraduate student-researchers at the University of Ottawa has developed a new biomanufacturing platform called Phytogene.

18 Mar 2025

Researchers Develop New Method for Assembling DNA Nanostructures

University at Albany researchers at the RNA Institute are pioneering new methods for designing and assembling DNA nanostructures, enhancing their potential for real-world applications in medicine, materials science and data storage.

13 Mar 2025

Light-Driven Protein Isolation Replaces Affinity Chromatography

Proteins are essential in the life sciences, playing a crucial role in fundamental research, biotechnological applications, and the development and production of pharmaceuticals.

6 Mar 2025

Novel Catalysis Yields Elusive Fluorinated Oxetanes for Drug Discovery

Researchers at the National University of Singapore have developed a groundbreaking catalytic process that transforms epoxides into fluorinated oxetanes.

24 Feb 2025

Mitochondrial Transfer Uncovered as Key Player in Cancer Immune Evasion

The immune system plays a key role in detecting and destroying cancer cells. Cancer immunotherapy works by programming immune cells to recognize and eliminate cancer cells.

12 Feb 2025

Synthetic Condensates Turbocharge Protein Production in Bacteria

Biomedical engineers at Duke University have developed a novel synthetic method that enhances bacteria's ability to produce higher quantities of specific proteins, including those that would typically harm them, such as antibiotics.

12 Feb 2025

Study Uncovers Immune Cell Interaction Driving Aggressive Brain Tumor Growth

A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, according to new research led by investigators at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins University School of Medicine.

11 Feb 2025

Scientists Design Ultra-Stable Synthetic Proteins That Could Change Drug Discovery

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology, transforming protein engineering.

3 Feb 2025

Danish Protein Analysis to Revolutionize the Biopharma Industry’s Impurity Control

Since 2007, the contract laboratory Alphalyse A/S has developed and refined a new method of impurity analysis in biological pharmaceuticals based on mass spectrometry (MS).

3 Feb 2025

High-Throughput Method Reveals the Effects of Active Substances on Cellular Metabolism

Researchers at the University of Basel are able to test in parallel the effects of over 1500 active substances on cell metabolism.

29 Jan 2025

Can Mechanochemistry Provide Greener Options for Pharmaceutical Manufacturing?

This study reveals efficient synthesis of ibuprofen:nicotinamide co-crystals via mechanochemistry, highlighting sustainability in pharmaceutical production.

27 Jan 2025

Breakthrough Achieved in Completing the Creation of First Synthetic Yeast Genome

Macquarie University researchers have worked with an international team of scientists to achieve a major milestone in synthetic biology by completing the creation of the final chromosome in the world's first synthetic yeast genome.

23 Jan 2025

Researchers Develop Strategy to Boost Pharmaceutical Production in CHO Cells

An international team of researchers led by the University of California San Diego has developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for treating cancer, autoimmune diseases and much more.

16 Jan 2025

Plant Research Reveals Unexpected Function for Key Cellular Protein

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which an organism's genetic code expresses itself. The fundamental breakthrough was discovered in apple cells but is relevant to all living organisms made of nucleus-containing cells, including humans.

24 Dec 2024

A Novel Method for Synthesizing Piperidines for Modern Medicine

A team of chemists from Scripps Research and Rice University has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study, published in Science, combines biocatalytic carbon-hydrogen oxidation and radical cross-coupling, offering a streamlined and cost-effective approach to create complex, three-dimensional molecules.

19 Dec 2024

Scientists Mimic Fungal Process to Create Novel Medicines

Since the unintentional 1928 discovery of penicillin by Alexander Fleming, fungi have been a treasure trove of medicinal compounds for almost a century.

19 Dec 2024

Researchers Use Bacteria to Convert Plastic Waste Into Human Therapeutics, Including Insulin

A new study from the Manchester Institute of Biotechnology describes a novel biological method to convert mixed municipal waste-like fractions – including food scraps, plastics, and textiles – into valuable bio-products.

9 Dec 2024