Proteome News and Research

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The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.

New Frontier in Protein Quality Control and Brain Health

Beyond their use as fuel during fasting, the body's production of ketones plays a part in controlling cellular functions and aging processes.

3 Dec 2024

Unmasking the Molecular Mechanisms of Melanoma

LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer.

24 Nov 2024

Mouse Aging Proteomic Atlas Provides Insight into Age-Related Protein Shifts

With the worldwide population aging at an unprecedented rate, the prevention of age-related diseases has become a prominent issue.

18 Nov 2024

Proteomics Analysis Reveals Aging-Related Changes in Bone

Bone mass declines with age, and the anabolic response to mechanical loading weakens. Although much research has focused on gene transcription, the mechanisms behind bone aging and the loss of mechanoresponsiveness at the protein level are still not well understood.

16 Oct 2024

Proteomics Reveals Age-Related Changes in Mouse Bone Formation

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 19 on October 12, 2024, entitled, "A proteomics approach to study mouse long bones: examining baseline differences and mechanical loading-induced bone formation in young-adult and old mice."

16 Oct 2024

Placental Protein Levels Offer Insights into Early-Onset Preeclampsia

A potentially fatal pregnancy complication, preeclampsia is characterized by persistently elevated blood pressure, which is exacerbated when it develops early in the first trimester.

15 Oct 2024

A Novel Function for STING in DNA Damage Response

A study published in the journal Molecular Cell has shed light on the multifaceted role of STING, a protein previously implicated in antiviral signaling pathways. The study reveals that STING also plays a crucial part in facilitating cellular stress resolution and promoting cell survival.

23 Sep 2024

Early Detection of Off-Target Binding Could Improve Drug Safety

Integral Molecular, a pioneer in antibody discovery and characterization, has published new findings in the journal mAbs, revealing that up to one-third of antibody-based drugs exhibit nonspecific binding to unintended targets.

18 Sep 2024

One-Third of Antibody Drugs Show Unintended Target Binding

Integral Molecular, a leader in antibody discovery and characterization, has published new research in the journal mAbs, revealing that as many as one-third of antibody-based drugs exhibit nonspecific binding to unintended targets.

18 Sep 2024

Global Ocean Microbiome Catalogue Opens New Frontiers In Marine Bioprospecting

Recent advancements in sequencing have led to the GOMC, a comprehensive catalog of marine microbiomes, enhancing prospects for biotechnological applications.

12 Sep 2024

Study Reveals Cytoskeleton as Key Component in Aging Dermal Fibroblasts

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 16 on August 27, 2024, entitled, "Proteomic and secretomic comparison of young and aged dermal fibroblasts highlights cytoskeleton as a key component during aging."

4 Sep 2024

Advancing Cardiovascular Drug Discovery: Translational Framework Leverages Genetic and Proteomic Insights

A validated framework to translate these recent advances in genoproteomics into clinical applications in cardiovascular drug development.

19 Aug 2024

Exploring Drug Repurposing For Arboviral Infections Through Cavitomix

The CavitOmiX drug discovery method, developed by the drug and enzyme discovery platform Innophore.

2 Aug 2024

The Role of Chemical Proteomics in Understanding Small Molecule-Protein Interactions

The various chemical proteomics methods with relevant examples.

31 Jul 2024

New Approach to Finding Antibiotic Alternatives Using Bacterial Data

Researchers have devised an approach for identifying novel antimicrobial drugs with clinical potential using bacterial databases, offering insights into finding alternatives to existing antibiotics.

17 Jul 2024

Simplified Proteomics Method Could Open the Door Toward Precision Medicine

Proteins are workhorses that carry out most of the biological functions in our cells.

12 Jun 2024

Unveiling the Chemical Secrets of Coral Reefs and Insights into Marine Health

What species exist on this coral reef, and how healthy are they?

7 Jun 2024

LC-MS/MS analysis provides new insights into early childhood health and development

The impact of a hydrolyzed formula dietary intervention on β-cell autoimmunity development.

30 May 2024

Integrative genomic study identifies two new potential drug targets in Mycobacterium tuberculosis

Researchers used existing whole genome sequences of M. tuberculosis and conducted a pangenomic analysis to identify potential drug targets.

28 May 2024

Deep Proteomic Analysis Unveils Molecular Changes in Skeletal Muscle with Aging and Resistance Training

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training."

2 May 2024