RNA Sequencing News and Research

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Guinea Pigs as a Robust Model for Human Embryo Research

The initial days of human embryo development, referred to as pre-implantation, are crucial.

11 Apr 2025

Placenta-Derived Signals Improve Liver Organoid Size and Function

Organoids, which are designed to mimic human organs, hold promise for both research and treatment;

9 Apr 2025

New Insights into How B Cells Strategically Clone High-Affinity Antibodies

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies.

20 Mar 2025

New Insights into RNA Editing Mechanisms for Autoimmune and Cancer Therapies

A research team led by Yang Gao from Rice University has made significant strides in understanding the molecular mechanisms of ADAR1, a protein that modulates ribonucleic acid (RNA) induced immune responses.

18 Mar 2025

Pig Retinal Organoids Offer Promising Model for Stem Cell-Based Vision Therapies

Inside the human eye, the retina is made up of several types of cells, including the light-sensing photoreceptors that initiate the cascade of events that lead to vision.

14 Mar 2025

Cellular Changes as Lung Damage Worsens During COVID-19 Revealed

Changes in the cellular response during lung damage caused by SARS-CoV-2 – the virus behind COVID-19 – have been uncovered.

10 Mar 2025

New Tool to Map the Origins and Journeys of Cells in Development and Disease

A new computational tool allows researchers to understand how the diverse cell types of the human body are made during development, and how diseases progress over time at the cellular level.

4 Mar 2025

Lactylation Levels Influence Cardiac Development and Regeneration in Mice

This study is led by Dr. Xiaodong Luan (Institute of Clinical Medicine, Peking Union Medical College Hospital), Dr. Shuyang Zhang (Department of Rare Diseases, Peking Union Medical College Hospital) and Dr. He Huang (Shanghai Institute of Materia Medica, Chinese Academy of Sciences).

3 Mar 2025

Age-Invariant Genes May Hold the Key to Understanding Aging and Longevity

A new research paper was published in Aging (Aging-US) on January 27, 2025, in Volume 17, Issue 1, titled "Age-invariant genes: multi-tissue identification and characterization of murine reference genes."

27 Feb 2025

RNA Splicing Errors May Hold the Key to Beating Gliomas Using Immunotherapy

Identifying splicing-related neoantigens in gliomas opens new avenues for immunotherapy, enhancing treatment strategies for this challenging brain tumor.

26 Feb 2025

Immunotherapy Breakthrough Targets Jumbled Proteins in Glioma

Immune therapy has transformed how cancer is treated, but many tumors continue to evade these treatments, thanks to their resemblance to healthy tissue.

20 Feb 2025

Single-Cell Sequencing Maps Pregnancy's Early Stages

Recent research has produced the first high-resolution molecular image of the equine endometrium, the inner lining of the uterus, before and after embryo implantation.

18 Feb 2025

PanK4 Protein Could Be Key to Better Control of Blood Sugar and Metabolism

Physical activity is not only important for fitness, but also for health. This is confirmed by a new study conducted under the direction of Prof. Dr. Maximilian Kleinert at the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE). His team discovered that the protein PanK4 plays a crucial role in the energy metabolism of skeletal muscles.

13 Feb 2025

Mutant Vimentin Promotes Aggressive Breast Cancer Growth

Vimentin is a type III intermediate filament (IF) protein typically expressed in cells that differentiate into connective tissue, blood vessels, and lymphatic tissue (mesenchymal cells).

12 Feb 2025

Research Sheds Light on How Obesity Affects Gene Expression in Fat Cells

As many as 40% of Americans are obese, putting them at an increased risk for high blood pressure, diabetes, stroke, heart disease and certain cancers, according to the CDC.

11 Feb 2025

Study Uncovers Immune Cell Interaction Driving Aggressive Brain Tumor Growth

A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, according to new research led by investigators at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins University School of Medicine.

11 Feb 2025

Random Versions of Human Genomes Created to Unlock Disease Mechanisms

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

3 Feb 2025

Human Cell Lines Reveal Genome's Tolerance to Structural Variation

The most advanced engineering of human cell lines to date has been accomplished by scientists, demonstrating that genomes are more robust against significant structural changes than previously understood.

31 Jan 2025

Research Identifies Key Immune Cells for Liver Repair

Our livers contain many different types of immune cells. New research by the team of Prof. Charlotte Scott (VIB-UGent Center for Inflammation Research) and colleagues now reveals that a specific activation state of one of these cell types is required for tissue repair following injury.

27 Jan 2025

Study Unveils Surprising Cause of Brain Cell Death in Huntington's Disease

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells.

17 Jan 2025