p53 Protein News and Research

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The TP53 is a gene that instructs the cell to produce tumor protein (p53) ; a vital transcription factor and tumor suppressor. P53 is known as the “guardian of the genome” as it helps in regulating the cell cycle and acts as a tumor suppressor.

New Insights into How Mutant p53 Promotes Tumor Growth

New Insights into How Mutant p53 Promotes Tumor Growth

Research from the Federal University of Rio de Janeiro (UFRJ) and the National Institute of Science and Technology for Structural Biology and Bioimaging (INBEB) in Brazil has uncovered a critical mechanism by which mutations in the p53 protein-;a key tumor suppressor known as the "guardian of the genome"-;turn other proteins into cancer-promoting agents

17 Sep 2024

New CRISPR Method Allows Comprehensive Screening of Cancer Mutations

New CRISPR Method Allows Comprehensive Screening of Cancer Mutations

Tumors can carry mutations in hundreds of different genes, and each of those genes may be mutated in different ways -; some mutations simply replace one DNA nucleotide with another, while others insert or delete larger sections of DNA.

13 Mar 2024

Innate Tumor Suppression Mechanism Uncovered

Innate Tumor Suppression Mechanism Uncovered

The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it.

5 May 2023

Novel Protein Involved in Tumor Suppression Identified

Novel Protein Involved in Tumor Suppression Identified

Understanding how cancer develops is critical for designing effective, personalized cancer therapies. Researchers have known for years that cancer begins with mutations in certain types of genes.

7 Apr 2023

Uncovering the complete 3D structure of p53 protein

Uncovering the complete 3D structure of p53 protein

By inducing cell repair or self-destruction, the tumor suppressor protein p53, often known as “the guardian of the genome,” shields the body’s DNA from daily stress or long-term damage.

2 Mar 2023

Study analyzes the role of eIF4A3 protein in cancer cell growth

Study analyzes the role of eIF4A3 protein in cancer cell growth

Cell growth requires new proteins and the same applies to cancer cells. Scientists analyzed the protein eIF4A3 and its role in the growth of cancer cells.

10 Aug 2021

Novel cell-to-cell communication network helps cancers regrow following genotoxic therapies

Novel cell-to-cell communication network helps cancers regrow following genotoxic therapies

In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options.

6 Apr 2021

Rare inherited mutation in TP53 gene predisposes to a wide range of cancers

Rare inherited mutation in TP53 gene predisposes to a wide range of cancers

Rare inherited mutations in the body's master regulator of the DNA repair system – the TP53 gene – can leave people at a higher risk of developing multiple types of cancer over the course of their lives.

17 Jul 2020

Study provides new strategies for treating different types of cancer

Study provides new strategies for treating different types of cancer

An RNA molecule involved in preventing the formation of tumors can modify its structure and thus regulate the production of proteins in the cell.

29 May 2020

WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5–MDM2–p53 pathway

WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5–MDM2–p53 pathway

A team of scientists has discovered that the WDR74 protein plays a vital role in metastasis progression in lung cancer and melanoma primary tumors.

22 Feb 2020

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