Cell Biology

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Breakthrough Study Identifies Critical Protein for Blood Stem Cell Self-Renewal

UCLA scientists have identified a protein that plays a critical role in regulating human blood stem cell self-renewal by helping them sense and interpret signals from their environment.

6 Jun 2024

Study Unveils Key Mechanism of Telomere Maintenance by CST–Polα/Primase

The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, resulting in telomere disorders with serious health consequences.

6 Jun 2024

Coordinated Proteins Aid the Immune System in Detecting and Destroying Threats

Bacteria, parasites, and viruses—the immune system tackles them all. Cells known as macrophages are at the forefront of the human immune response, recognizing intruders and controlling how the entire immune system responds.

6 Jun 2024

How Tumor-Associated Fibrosis Shapes Immune Responses

Immunotherapy is based on harnessing a person's own immune system to attack cancer cells. However, patients with certain tumors do not respond to these therapies and it remains unclear why.

5 Jun 2024

Exploring the Dynamic Interactions of Circadian Clock Proteins

Circadian clocks, which drive circadian rhythms, are entwined with many essential systems in living things including plants, fungi, insects, and even humans.

5 Jun 2024

High-Accuracy DNA Methylation Clocks Illuminate Age-Related Changes in Primate Ovaries

The ovary is an essential organ for female fertility, and its age-dependent decline in function is a major cause of infertility.

5 Jun 2024

UC San Diego Researchers Find Cause of Cellular 'Short-Circuit'

A group of researchers at University of California San Diego has identified the cause of a "short-circuit" in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases.

5 Jun 2024

Unveiling Age-Related Lipid Alterations

Researchers from the RIKEN Center for Integrative Medical Sciences (IMS) revealed various age-related alterations in mice's lipid metabolism, across both organs and sexes.

5 Jun 2024

Researchers Identify Molecular Stop Signal in Cell Division Monitoring

Every second, many million cells divide throughout the body. During nuclear division (mitosis), the genetic material must be divided correctly and fully amongst daughter cells; faults in this process can result in improper development or genetic diseases, and many cancer cells have an uneven number of chromosomes.

5 Jun 2024

Researchers Advance Single-Molecule DNA Sequencing Techniques

In recent years, technologies that allow scientists to investigate a person's DNA at single-molecule resolution have greatly increased the knowledge of the human genome, microbiome, and the genetic basis of disease.

5 Jun 2024

Sphere Fluidics Launches Cyto-CellectPLUS to Accelerate Cell Line Development Workflows

Sphere Fluidics, a leading provider of innovative microfluidics-based solutions for single-cell analysis and isolation, today announced the launch of Cyto-Cellect®PLUS.

From Sphere Fluidics Limited 5 Jun 2024

Exploring Hepatic and Serum Proteomic Signatures in Werner Syndrome Mice

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 10, entitled, "Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model."

4 Jun 2024

Brain Organoids Emerge as Powerful Tool for Drug Discovery in Mitochondrial Disease

The use of brain organoids in screening for drugs against mitochondrial diseases, which have hitherto presented challenges in treatment.

4 Jun 2024

Stem Cell Factor Levels Show Promise in Predicting Successful IVF for Endometriosis

The ability of serum levels of stem cell factor to indicate the quality of oocyte and blastocyst development.

4 Jun 2024

Study Uncovers Fungal Self-Destruct Mechanism

Scientists have discovered that the most widely-used class of antifungals in the world cause pathogens to self-destruct.

3 Jun 2024

New Insights into Human Embryonic Development Using Stem Cell Models

A new study using stem cell-based models has shed new light on how the human embryo begins to develop, which could one day benefit the development of fertility treatment.

3 Jun 2024

"Cervix-on-a-Chip" Offers Promise for New Bacterial Vaginosis Treatments

Bacterial Vaginosis (BV) has been identified as one of the many unmet needs in women's health and affects more than 25% of reproductive-aged women.

3 Jun 2024

Non-Destructive Test Identifies Potent Cartilage Repair Cells

Researchers from Critical Analytics for Manufacturing Personalized-medicine (CAMP) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, and collaborators from the National University of Singapore Tissue Engineering Programme (NUSTEP) have discovered a more efficient method for evaluating the ability of mesenchymal stromal cells (MSCs) to regenerate cartilage.

3 Jun 2024

Astrocyte Receptor Effects Differ Dramatically Between Sexes

Weill Cornell Medicine scientists have uncovered the first evidence that astrocyte receptors can trigger opposite effects on cognitive function in male and female preclinical models.

31 May 2024