Overview
ioMicroglia, the human induced pluripotent stem cell (iPSC)-derived microglia is precision reprogrammed using opti-ox™ technology. Within 10 days post-revival, ioMicroglia are all set for experimentation, expressing (>90%) key phenotypic markers, such as TMEM119, IBA1, P2RY12, CX3CR1, CD45, CD11b, and CD14.
ioMicroglia exhibits main functional traits such as phagocytosis and proinflammatory cytokine secretion and could be co-cultured with ioGlutamatergic Neurons™ with retention of phagocytic function.
ioMicroglia offers a quick, constant, functional, and user-friendly hiPSC-based model for neurodegenerative disease research and drug development.
Features
Quick
Quickly maturing human microglia that are ready to utilize within 10 days post-revival.
Functional
ioMicroglia display main phagocytic and cytokine secretion functions.
Co-culture compatible
Appropriate for co-culture studies with neurons.
Applications
- Drug development
- Disease modeling
- Co-culture studies
- Neuroinflammation research
- Transcriptome analysis