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“Bacterial suicide squad” recruits and activates innate and adaptive antitumor immune responses

Combining discoveries in cancer immunology with sophisticated genetic engineering, Columbia University researchers have created a sort of "bacterial suicide squad" that targets tumors, attracting the host's own immune cells to the cancer to destroy it. The new work, published today in Science Advances, marks a major step forward in efforts to enlist non-pathogenic bacteria to combat cancer.

9 Mar 2023

Monitoring the development and maturation of cardiomyocytes using tissue-embedded devices

Research in animal models has demonstrated that stem-cell derived heart tissues have promising potential for therapeutic applications to treat cardiac disease. But before such therapies are viable and safe for use in humans, scientists must first precisely understand on the cellular and molecular levels which factors are necessary for implanted stem-cell derived heart cells to properly grow and integrate in three dimensions within surrounding tissue.

9 Mar 2023

Study findings reveal drug development possibilities for brain diseases

Nearly two dozen experimental therapies targeting the immune system are in clinical trials for Alzheimer's disease, a reflection of the growing recognition that immune processes play a key role in driving the brain damage that leads to confusion, memory loss and other debilitating symptoms.

9 Mar 2023

Scientists reveal mechanisms behind oxygen toxicity

When it comes to oxygen, you can have too much of a good thing. Breathing air that contains higher levels of oxygen than the usual 21 percent found in Earth's atmosphere can cause organ damage, seizures, and even death in people and animals, particularly if it's in excess of the body's oxygen needs. Until now, however, scientists have mostly speculated about the mechanisms behind this phenomenon, known as oxygen toxicity, or hyperoxia.

9 Mar 2023

New gene resource for improving root systems

A strong root system allows crops to absorb water and nutrients from the soil, but scientists have little information about the genes that control root development. Recent research published in New Phytologist reveals that blocking a negative regulator gene of root development leads to enhanced root growth in plants.

8 Mar 2023

Experts sequence the faba bean genome

The faba bean genome, which at 13 billion bases is more than four times the size of the human genome, has been sequenced for the first time and is published today (08 March 2023), in Nature. This is an extraordinary technical achievement and crucial to efforts to breed beans with optimum nutritional content and sustainability of production.

8 Mar 2023

Understanding gas transfer between the atmosphere and ocean can lead to better climate models

The injection of bubbles from waves breaking in turbulent and cold high-latitude regions of the high seas is an underappreciated way in which atmospheric gases are transported into the interior ocean.

8 Mar 2023

Liver-produced hormone protects mice against the harmful effects of intoxication

A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn't receive this treatment, UT Southwestern researchers report in a new study.

8 Mar 2023

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Pediatric acute myeloid leukemia or pAML is a childhood blood cancer, one that has proved confounding to clinicians and researchers, with a high relapse rate and relatively few identified genetic mutations (compared to the adult version) that might explain its cause.

8 Mar 2023

Plant roots drive soil animal communities in the tropics, study shows

A research team led by the University of Göttingen has shed new light on the importance of plant roots for belowground life, particularly in the tropics.

8 Mar 2023

Scientists discover mechanism behind how plants can develop long-term immunity to stress

A mechanism behind how plants can develop long-term immunity to stress has been discovered by scientists at the University of Sheffield.

8 Mar 2023

Short exposure to altered gravity does not alter leukocyte immunophenotyping and functional capacity

Space travel has always tested the human body by the effects of the new conditions of altered gravity on biological systems.

8 Mar 2023

LDL-mediated nanoparticle drug delivery could potentially circumvent high-grade gliomas

New research has shown that the blood vessels that feed aggressive brain tumors have receptors that could allow a new type of drug-containing nanoparticle to be used to starve the tumors of the energy they use to grow and spread, and also cause other disruptions to their adapted existence, even killing themselves.

8 Mar 2023

Discovery could establish an effective control environment for chromosome instability

A research team, affiliated with UNIST has unveiled a key factor involved in the DNA damage response (DDR), homologous recombination (HR) and DNA interstrand crosslink (ICL) repair.

8 Mar 2023

Revolutionary drug blocks a gene associated with driving the spread of bone cancer

Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer.

8 Mar 2023

Socioeconomic and genetic factors likely interact in an additive way to increase risk of metabolic diseases

New research led by investigators at Massachusetts General Hospital, a founding member of Mass General Brigham, indicates that socioeconomic and genetic factors likely interact in an additive way to affect people's risks of developing obesity and type 2 diabetes.

8 Mar 2023

AI tool can accurately identify normal and abnormal chest X-rays in a clinical setting

An artificial intelligence tool can accurately identify normal and abnormal chest X-rays in a clinical setting, according to a study published in Radiology, a journal of the Radiological Society of North America.

8 Mar 2023

BGI’s fluorescent RT-PCR kit obtains market access qualification for detecting SARS-CoV-2, IFV A, IFV B in Australia

On March 2, BGI's Multiplex Real-time Fluorescent RT-PCR Kit for Detecting SARS-CoV-2, Influenza A Virus and Influenza B Virus obtained market access qualification to enter the Australian Register of Therapeutic Goods.

8 Mar 2023

Analyzing microscopic chalk disks coccoliths formed by the marine algae

Under the guidance of Rutgers University, a research group learning about virus-host interactions of worldwide abundant and armor-plated marine algae, Emiliania huxleyi, has discovered that the circular and chalk plates produced by the algae have the potential to serve as catalysts for viral infection.

From Rutgers University 7 Mar 2023

An alternative option to treat ADCY5-related dyskinesia in patients

The asthma medication theophylline can be used to treat the movement disorder ADCY5-related dyskinesia. A recent study conducted by Martin Luther University Halle-Wittenberg (MLU), University Medicine Halle, and the University of Leipzig Medical Center demonstrated this.

7 Mar 2023

Life Science News

“Bacterial suicide squad” recruits and activates innate and adaptive antitumor immune responses

Monitoring the development and maturation of cardiomyocytes using tissue-embedded devices

Study findings reveal drug development possibilities for brain diseases

Scientists reveal mechanisms behind oxygen toxicity

New gene resource for improving root systems

Experts sequence the faba bean genome

Understanding gas transfer between the atmosphere and ocean can lead to better climate models

Liver-produced hormone protects mice against the harmful effects of intoxication

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Plant roots drive soil animal communities in the tropics, study shows

Scientists discover mechanism behind how plants can develop long-term immunity to stress

Short exposure to altered gravity does not alter leukocyte immunophenotyping and functional capacity

LDL-mediated nanoparticle drug delivery could potentially circumvent high-grade gliomas

Discovery could establish an effective control environment for chromosome instability

Revolutionary drug blocks a gene associated with driving the spread of bone cancer

Socioeconomic and genetic factors likely interact in an additive way to increase risk of metabolic diseases

AI tool can accurately identify normal and abnormal chest X-rays in a clinical setting

BGI’s fluorescent RT-PCR kit obtains market access qualification for detecting SARS-CoV-2, IFV A, IFV B in Australia

Analyzing microscopic chalk disks coccoliths formed by the marine algae

An alternative option to treat ADCY5-related dyskinesia in patients

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