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Study reveals why the FMO5 gene produces an enzyme with a different activity

Our body produces lots of enzymes that break down toxic substances. One class of such enzymes are the flavin-containing monooxygenases (FMOs), which are present in all tetrapods. Humans have five different FMO genes, of which the first four display the same activity. However, the fifth FMO gene triggers a different breakdown reaction. University of Groningen biochemists have succeeded in resurrecting the ancestral genes of all tetrapod FMOs to show how this divergence has occurred. Their results appear on 24 February in Nature Communications.

28 Feb 2023

Study elucidates the cellular changes caused by exposure to adversity during childhood

A new brain connection discovered by University of California, Irvine researchers can explain how early-life stress and adversity trigger disrupted operation of the brain's reward circuit, offering a new therapeutic target for treating mental illness. Impaired function of this circuit is thought to underlie several major disorders, such as depression, substance abuse and excessive risk-taking.

28 Feb 2023

Voluntary initiatives to promote the replacement of lead in UK game hunting are not very effective

Three years into a five-year pledge to completely phase out lead shot in UK game hunting, a Cambridge study finds that 94% of pheasants on sale for human consumption were killed using lead.

27 Feb 2023

Study highlights key role of group 2 innate lymphoid cells in shaping the alveolar niche

A study conducted by researchers at the University of Liège on group 2 innate lymphoid cells (or ILC2s) shows that the functional reprogramming of these cells following their exposure to viruses allows our body to react differently to exposure to certain respiratory allergens.

27 Feb 2023

Biodiversity triggered the ecological collapse following the “great dying”

The Permian-Triassic extinction event, commonly referred to as the “Great Dying,” which took place 252 million years ago, was the most devastating mass extinction in the history of life on Earth.

27 Feb 2023

New center offers electron microscope services to the scientific community

The Joint Electron Microscopy Center at ALBA (JEMCA) was established through the collaboration of various research agencies to open a new center within the ALBA Synchrotron building that provides electron microscope assistance to the scientific community.

27 Feb 2023

Artificial BBB model can help determine how well antibody-based therapies can enter the brain

A research group at Uppsala University has developed a simple and effective artificial blood-brain barrier model that can be used to determine how well antibody-based therapies can enter the brain.

27 Feb 2023

Study: Oral verapamil improves the pancreas' insulin secretion in children with newly-diagnosed TID

Published in JAMA, a University of Minnesota led study shows that verapamil, a drug commonly used to treat high blood pressure and heart conditions, can have a beneficial effect on the pancreas in children with newly-diagnosed type 1 diabetes (T1D).

27 Feb 2023

Women over 50 with genetic BRCA1 or BRCA2 mutation face a high risk of cancer

Although genetic mutations in BRCA1 or BRCA2 are associated with a younger onset of breast and ovarian cancer, women with these genetic mutations continue to face a high risk of cancer incidence after age 50, even if they have not been previously diagnosed with cancer.

27 Feb 2023

New molecular understanding of how head injury may contribute to glioma risk

Researchers from the UCL Cancer Institute have provided important molecular understanding of how injury may contribute to the development of a relatively rare but often aggressive form of brain tumor called a glioma.

27 Feb 2023

Study shows why a specific gene mutation has opposite effects on mice and human cancers

A small but significant metabolic difference between human and mouse lung tumor cells, has been discovered by Weill Cornell Medicine researchers, explaining a discrepancy in previous study results, and pointing toward new strategies for developing cancer treatments.

27 Feb 2023

New model simplifies the understanding of vascular malformations

Our bodies are made up of 60,000 miles of complex pipes that play a vital role in transporting nutrients throughout our bodies, performing waste disposal, and supplying our organs with fresh oxygen and blood.

27 Feb 2023

Herpesvirus infection boosts host cellular immunity: Study

A new editorial was published in Genes & Cancer on January 19th, 2023, entitled, "Severe herpesvirus infection beats adult T-cell leukemia/lymphoma."

27 Feb 2023

MoBIE: New user-friendly, freely available tool for sharing large imaging data sets

High-resolution microscopy techniques, for example electron microscopy or super-resolution microscopy, produce huge amounts of data.

24 Feb 2023

Single gene controls a switch between two alternative cell fates in sea anemone

When scientists disabled a single regulatory gene in a species of sea anemone, a stinging cell that shoots a venomous miniature harpoon for hunting and self-defense shifted to shoot a sticky thread that entangles prey instead, according to a new study.

24 Feb 2023

Insilico Medicine: IND application for first generative AI-designed drug for COVID-19 approved

Insilico Medicine, a clinical-stage biotech company powered by generative AI, today announces that China National Medical Products Administration (NMPA) has approved the Investigational New Drug (IND) application for ISM3312, an orally available 3CLpro inhibitor generated and designed with the support of Insilico's proprietary generative chemistry platform Chemistry42 for the treatment of COVID-19.

24 Feb 2023

Synthetic hydrogels provide an effective scaffold for brain tissue growth

Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.

24 Feb 2023

Genes can be used to better predict the likelihood of kidney cancer recurrence

A decade-long international study into kidney cancer has shown that doctors can predict the likelihood of a patient's disease returning by looking at DNA mutations in their tumors.

24 Feb 2023

Researchers tease apart the molecular components involved in abdominal aneurysms

When the artery that supplies the stomach and the liver forms a bulge that ruptures, this medical emergency results in the deaths of 50 percent of patients before they reach the hospital.

24 Feb 2023

Discovery of a lung stem cell subset provides opportunity for new COPD treatments

Respiratory viral infections pose significant morbidity and mortality to patients with chronic lung diseases like emphysema and COPD, causing exacerbations that drive destruction of normal lung tissue, and leading to one of the most common diagnoses for hospital admissions.

24 Feb 2023

Life Science News

Study reveals why the FMO5 gene produces an enzyme with a different activity

Study elucidates the cellular changes caused by exposure to adversity during childhood

Voluntary initiatives to promote the replacement of lead in UK game hunting are not very effective

Study highlights key role of group 2 innate lymphoid cells in shaping the alveolar niche

Biodiversity triggered the ecological collapse following the “great dying”

New center offers electron microscope services to the scientific community

Artificial BBB model can help determine how well antibody-based therapies can enter the brain

Study: Oral verapamil improves the pancreas' insulin secretion in children with newly-diagnosed TID

Women over 50 with genetic BRCA1 or BRCA2 mutation face a high risk of cancer

New molecular understanding of how head injury may contribute to glioma risk

Study shows why a specific gene mutation has opposite effects on mice and human cancers

New model simplifies the understanding of vascular malformations

Herpesvirus infection boosts host cellular immunity: Study

MoBIE: New user-friendly, freely available tool for sharing large imaging data sets

Single gene controls a switch between two alternative cell fates in sea anemone

Insilico Medicine: IND application for first generative AI-designed drug for COVID-19 approved

Synthetic hydrogels provide an effective scaffold for brain tissue growth

Genes can be used to better predict the likelihood of kidney cancer recurrence

Researchers tease apart the molecular components involved in abdominal aneurysms

Discovery of a lung stem cell subset provides opportunity for new COPD treatments

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