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All-RNA Gene Writing Method Paves Way for Precise Gene Editing in Human Cells

A novel gene-writing technology based on retrotransposons.

15 Jul 2024

Advancing the Understanding of Circadian Regulation with Melanopsin DNA Aptamers

DNA aptamers of melanopsin that regulate the clock hands of biological rhythms were developed by the Toyohashi University of Technology and the National Institute of Advanced Industrial Science and Technology (AIST) group.

15 Jul 2024

Scientists Discover Fossils of Ancient Chromosomes in the Remains of Woolly Mammoth

A team led by scientists from Baylor College of Medicine, University of Copenhagen, and Centre Nacional d'Anàlisi Genòmica and Centre for Genomic Regulation report discovering fossils of ancient chromosomes in the remains of a woolly mammoth that died 52,000 years ago.

12 Jul 2024

New Gene Editing Technique Outperforms Existing Therapies

Cystic fibrosis, a prevalent genetic disorder, leads to thick mucus accumulation in the lungs and other parts of the body, resulting in breathing difficulties and infections.

11 Jul 2024

Phage-Derived Endolysin Offers Targeted Treatment for Dysbiosis-Driven Acute GVHD

Allogenic hematopoietic cell transplantation (allo-HCT) involves transferring healthy donor stem cells to recipients with conditions like blood cancer, bone marrow failure, or certain genetic blood disorders.

11 Jul 2024

New Insights into ILC2 Development Could Lead to Innovative Therapies for Allergic Diseases

Scientists have discovered a novel mechanism of ILC2 immune cell development which may be involved in exacerbating allergic diseases.

11 Jul 2024

UNC-Chapel Hill Study Reveals New Mechanism of Gene Regulation Beyond Histone Modification

University of North Carolina at Chapel Hill researchers have determined whether a specific chemical modification of a protein that packages the genome called a histone affects gene activity and cell proliferation according to the paper, "Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation," published in Genes & Development.

11 Jul 2024

Retron-Based Tool Enables Multi-Site DNA Editing

Genome editing has become a widely adopted technology to modify DNA in cells, allowing scientists to study diseases in the lab and develop therapies that repair disease-causing mutations.

10 Jul 2024

New Pipeline Studies Viruses in Humans and Coral Reefs

Tens of millions of still-unknown or poorly understood viruses have the potential to cause diseases, including new pandemics, and impact the health of valuable terrestrial and marine environments.

10 Jul 2024

A New Tool to Unravel the Mysteries of Metabolic Genes

A novel discovery platform has been created by a multidisciplinary research team to investigate the role of genes involved in metabolism, which is the culmination of all chemical reactions necessary for life.

9 Jul 2024

Integrating Genomic Data for Enhanced Fruit Tree Breeding

Genotyping techniques can be used to select fruit trees with desired traits at the seedling stage, increasing the efficiency of fruit tree breeding.

8 Jul 2024

Comprehensive Analysis Identifies Risk Factors for Multiple Cancers

Scientists have discovered over 5,000 genetic variations that give rise to specific cancers, along with a possible therapeutic target that could be used to treat or even stop these cancers from growing.

8 Jul 2024

Selfish No More: Genetic Elements Give Phages a Competitive Edge

Curious bits of DNA tucked inside genomes across all kingdoms of life historically have been disregarded since they don't seem to have a role to play in the competition for survival.

7 Jul 2024

Bowel Cancer Cells Use Genetic On-Off Switch' to Evade the Immune System

Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that's been observed for the first time by researchers at UCL and University Medical Center Utrecht.

4 Jul 2024

Unveiling the Role of Exons in Protein Foldability and Evolution

A new study led by Rice University's Peter Wolynes offers new insights into the evolution of foldable proteins. The research was published in the Proceedings of the National Academy of Sciences.

4 Jul 2024

Using Mobile Data to Track the Spread and Evolution of Superbugs

Key insights into the global spread, evolution, and resistance patterns of a major bacterium causing pneumonia and meningitis have been revealed through the combination of genomic data and human travel patterns over 14 years in South Africa.

4 Jul 2024

Researchers Decode Impact of Every Possible Alteration in Critical Cancer Gene

Scientists at the Francis Crick Institute have mapped all possible outcomes of changes to a tumor-suppressing gene called VHL, as the first step in a massive research project to unravel the consequences of tens of thousands of genetic variations in genes linked to cancer.

4 Jul 2024