Cancer News and Research

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Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms new cells as you need them, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of the body.

Hormone drugs may help disarm coronavirus spike protein and stop disease progression

Hormone drugs that reduce androgen levels may help disarm the coronavirus spike protein used to infect cells and stop the progression of severe COVID-19 disease, suggests a new preclinical study from researchers in the Abramson Cancer Center at the University of Pennsylvania and published online in Cell Press's iScience.

23 Mar 2021

Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

Oncotarget published "Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells" which reported that although the molecular mechanism behind the antitumor properties of NSAIDs has been largely attributed to inhibition of cyclooxygenases , several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects.

23 Mar 2021

Study maps structure, mechanism of membrane enzyme that has a role in chronic inflammation, cancer

A majority of the drugs work through the membranes surrounding the cells of the body.

22 Mar 2021

Low representation of minority groups in genomic databases may impact therapy selection

Low representation of minority groups in public genomic databases may affect therapy selection for Black patients with cancer, according to new Mayo Clinic research published in npj Precision Oncology.

22 Mar 2021

Study advances CAR T cell therapy targeted at cancer

Cancer immunotherapy involves the activation of cells in the patient’s own immune system to fight tumor cells.

19 Mar 2021

Rare genetic variants contribute to increased risk for lung cancer

In the United States, lung cancer is the main cause of cancer death in both male and female populations.

19 Mar 2021

Study identifies new biomarkers for the prognosis of gastric adenocarcinoma

A study headed by UCM reports that polymorphisms in gene TGFB1 and low plasma levels of protein TGFB1 serve as biomarkers for the gastric adenocarcinoma prognosis.

19 Mar 2021

Study shows beneficial effects of gene therapy can be observed even after several decades

A new study shows that the advantageous effects of gene therapy can be observed several decades after the body clears the transplanted blood stem cells.

From University College London 18 Mar 2021

New highly sensitive RNA detection method advances in situ transcriptomics

Human cells typically transcribe half of their roughly 20,000 genes into RNA molecules at any given time. Just like with proteins, the function of those RNA species not only relies on their abundance but also their precise localization within the 3D space of each cell.

18 Mar 2021

Researchers develop new cell-based test system to identify immunoregulatory modulators

Our immune system is very successful when it comes to warding off viruses and bacteria. It also recognizes cancer cells as potential enemies and fights them. However, cancer cells have developed strategies to evade surveillance by the immune system and to prevent immune response.

18 Mar 2021

New machine learning method detects the pH of a cell to identify whether it is cancerous

Cancerous cells differ from healthy cells in various significant ways. This helps identify them as harmful.

17 Mar 2021

Study reveals substantial difference in selection and timing of genetic tests for non-small-cell lung cancer

During biomarker testing, certain disease-associated molecules are examined to estimate the progression of a disease and its response to treatments.

17 Mar 2021

Key protein regulates cells’ innate defense mechanisms

Scientists from the University of Illinois Chicago (UIC) have found that heparanase (HPSE) is an important regulator of innate defense mechanisms of cells.

17 Mar 2021

Study reveals molecular profiles of Parkinson's disease

The second most common neurodegenerative disorder is Parkinson’s disease, but despite this, not much is known about the causes of this condition.

17 Mar 2021

ADAR1 protein offers a potential therapeutic target for cancer

A research team has discovered a new role of ADAR1 and found that the ADAR1p110 isoform controls genome stability at the ends of chromosomes.

15 Mar 2021

Cryogenic electron microscopy helps visualize 3D structure of complex responsible for gene regulation

A research team has looked inside a human cell to visualize a multi-subunit machine that is responsible for controlling the expression of genes.

15 Mar 2021

Researchers generate thyroid mini-organs in the lab

Hormones produced by the thyroid gland are essential regulators of organ function. The absence of these hormones either through thyroid dysfunction due to, for example, irradiation, thyroid cancer or autoimmune disease or thyroidectomy leads to symptoms like fatigue, feeling cold, constipation, and weight gain.

12 Mar 2021

Study offers fresh insights into infection process during spaceflight

Astronauts face many challenges to their health, due to the exceptional conditions of spaceflight. Among these are a variety of infectious microbes that can attack their suppressed immune systems.

10 Mar 2021

Comprehensive mutation map helps better understand the biological processes underlying Alzheimer's

A study published in the journal eLife made all the possible mutations in the amyloid beta peptide and tested how they influence its aggregation into plaques, a pathological hallmark of Alzheimer's disease.

10 Mar 2021

Adhesion strength and contractility enable metastatic cancer cells to display adurotactic behavior

Bioengineers at the University of California San Diego and San Diego State University have discovered a key feature that allows cancer cells to break from typical cell behavior and migrate away from the stiffer tissue in a tumor, shedding light on the process of metastasis and offering possible new targets for cancer therapies.

From UC San Diego 10 Mar 2021

Cancer News and Research

Hormone drugs may help disarm coronavirus spike protein and stop disease progression

Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

Study maps structure, mechanism of membrane enzyme that has a role in chronic inflammation, cancer

Low representation of minority groups in genomic databases may impact therapy selection

Study advances CAR T cell therapy targeted at cancer

Rare genetic variants contribute to increased risk for lung cancer

Study identifies new biomarkers for the prognosis of gastric adenocarcinoma

Study shows beneficial effects of gene therapy can be observed even after several decades

New highly sensitive RNA detection method advances in situ transcriptomics

Researchers develop new cell-based test system to identify immunoregulatory modulators

New machine learning method detects the pH of a cell to identify whether it is cancerous

Study reveals substantial difference in selection and timing of genetic tests for non-small-cell lung cancer

Key protein regulates cells’ innate defense mechanisms

Study reveals molecular profiles of Parkinson's disease

ADAR1 protein offers a potential therapeutic target for cancer

Cryogenic electron microscopy helps visualize 3D structure of complex responsible for gene regulation

Researchers generate thyroid mini-organs in the lab

Study offers fresh insights into infection process during spaceflight

Comprehensive mutation map helps better understand the biological processes underlying Alzheimer's

Adhesion strength and contractility enable metastatic cancer cells to display adurotactic behavior

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