Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Identification of a bivalent histone-mark switch essential for angiogenesis

Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells.

9 Feb 2022

San Antonio researchers report a new mechanistic target for leukemia drug development

Scientists at The University of Texas Health Science Center at San Antonio believe it may be possible to prevent DNA changes driven by two proteins highly active in leukemia and other cancers.

7 Feb 2022

Scientists discover families of proteins that could predict organ transplant rejection

Northwestern University scientists have discovered families of proteins in the body that could potentially predict which patients may reject a new organ transplant, helping inform decisions about care.

28 Jan 2022

Leukemia-on-a-chip; The Future of Preventing Therapy Resistance?

We speak to Dr. Chao Ma, one of the speakers at SLAS 2022, about his groundbreaking 'leukemia-on-a-chip' technology and its future within therapy resistance.

From Society for Laboratory Automation and Screening (SLAS) 27 Jan 2022

Culturing marine sponge cells in 3D could scale-up production of biomass, bioactive metabolites

There are more than 9,000 species of marine sponges (Phylum Porifera) worldwide, which are a source of novel natural products.

25 Jan 2022

Producing New Antibiotics Through Gene Editing

In this interview, we speak to Professor Jason Micklefield about his latest research that may be able to produce new antibiotics through gene-editing technologies.

From The University of Manchester 24 Jan 2022

Evaporators assist academic drug discovery

BioChromato Inc reports how the renowned Chemistry Research Laboratories (CRL) at Oxford University (UK) are using several Smart Evaporator C1 units to support their drug discovery activities in therapeutic areas including oncology and regenerative medicine.

From BioChromato Inc. 19 Jan 2022

Experts develop CRISPR-Cas9-mediated inheritance control in male mice

The world’s first CRISPR-Cas9 genetic editing-based strategy to regulate inheritance in mammals was declared nearly three years ago.

From UC San Diego 13 Jan 2022

Experts develop AI-based binding site detection in nucleic acid macromolecules

Skoltech’s iMolecule group has created a solution that employs data on the structure of molecules to detect sites where possible drug candidates could interact.

13 Jan 2022

TetraScience announces 300% ARR growth and 2021 achievements; prepares for next phase of growth

TetraScience, the R&D Data Cloud Company, is pleased to share highlights from a record-breaking 2021 fiscal year, including 300% annual recurring revenue (ARR) growth, an $80M Series B funding round, and full operationalization of the Tetra Partner Network.

From TetraScience, Inc. 12 Jan 2022

Pyroptosis is not a one-way ticket, it can be halted and controlled

A study published by researchers at the University of Illinois Chicago describes a new method for analyzing pyroptosis -; the process of cell death that is usually caused by infections and results in excess inflammation in the body -; and shows that process, long thought to be irreversible once initiated, can in fact be halted and controlled.

11 Jan 2022

NeoCura and PhoreMost Announce Research Collaboration to Explore Novel Cancer Therapeutics

NeoCura and PhoreMost today announced an oncology drug discovery research collaboration.

From PhoreMost 11 Jan 2022

Research analyzes horizontal gene transfer between viruses and eukaryotes

The level at which viruses can pick up genes from their hosts to hone their infection process is illustrated by the first analysis of viral horizontal gene transfer.

7 Jan 2022

PhoreMost and POLARISqb announce a multi-target collaboration to investigate next-generation cancer therapies

PhoreMost Limited and Polaris Quantum Biotech (POLARISqb) today announced a collaboration to study oncology targets currently considered undruggable.

From PhoreMost 6 Jan 2022

Cryobioprinting uses a bioink embedded with cells to print frozen and complex structures

A new technique takes bioprinting -; in which an ink of cells is printed, layer by layer, to form a structure -; to a whole new, and icy level. Investigators from the Zhang lab at Brigham and Women's Hospital have developed a technology that they term "cryobioprinting," a method that uses a bioink embedded with cells to print frozen, complex structures that can be easily stored for later use.

31 Dec 2021

Drug Discovery News and Research

Further Reading

Identification of a bivalent histone-mark switch essential for angiogenesis

San Antonio researchers report a new mechanistic target for leukemia drug development

Scientists discover families of proteins that could predict organ transplant rejection

Leukemia-on-a-chip; The Future of Preventing Therapy Resistance?

Culturing marine sponge cells in 3D could scale-up production of biomass, bioactive metabolites

Producing New Antibiotics Through Gene Editing

Evaporators assist academic drug discovery

Experts develop CRISPR-Cas9-mediated inheritance control in male mice

Experts develop AI-based binding site detection in nucleic acid macromolecules

TetraScience announces 300% ARR growth and 2021 achievements; prepares for next phase of growth

Pyroptosis is not a one-way ticket, it can be halted and controlled

NeoCura and PhoreMost Announce Research Collaboration to Explore Novel Cancer Therapeutics

Research analyzes horizontal gene transfer between viruses and eukaryotes

PhoreMost and POLARISqb announce a multi-target collaboration to investigate next-generation cancer therapies

Cryobioprinting uses a bioink embedded with cells to print frozen and complex structures

Discovery may lead to a better understanding of prion and other neurodegenerative diseases

New computational method could help quickly screen billions of drug compounds

Developing Sperm Cells from Primate Stem Cells

Study finding helps better comprehend necroptosis for treating diseases

Researchers identify toxic senescent cells in the brain as potential target for Alzheimer’s treatment

eBook: Essential Guide to Organoids for Drug Discovery Applications eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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