CRISPR News and Research

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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

STING-seq Discovers Causal Variants and Genetic Mechanisms for Blood Cell Traits

A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins.

5 May 2023

Innate Tumor Suppression Mechanism Uncovered

The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it.

5 May 2023

Mini Organs Provide New Insights Into Fibrolamellar Carcinoma

Scientists of the Princess Máxima Center for pediatric oncology and Hubrecht Institute in the Netherlands have revealed new scientific insights into the features of fibrolamellar carcinoma (FLC), a rare type of childhood liver cancer

4 May 2023

New Approach Could Power the Development of Advanced Cell Therapies

A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods.

2 May 2023

The Pivotal Role of Combinatorial CRISPR Gene Editing in the Elimination of HIV-1 Infection

Recent research from Temple University’s Lewis Katz School of Medicine and the University of Nebraska Medical Center demonstrates that gene-editing therapy aimed at two targets - HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that aids the virus getting into cells—can effectively eliminate HIV infection.

2 May 2023

Csx28 Membrane Protein Enhances CRISPR's Anti-Viral Defense

CRISPR achieved scientific popularity for its capacity to quickly and precisely edit genes. At the core, however, CRISPR systems are immune systems that aid bacteria to safeguard themselves from viruses through targeting and abolishing viral RNA and DNA.

28 Apr 2023

New Genome Editing Technology Achieves Precise Targeted Insertion of DNA Segments

A new genome editing technology was developed by GAO Caixia’s group from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS). This technology achieves successful and accurate targeted insertion of large DNA segments in plants.

26 Apr 2023

A Rapid Method for the Quantitative Detection of miRNA

Researchers investigating the growth of a roundworm discovered a tiny RNA molecule that controlled the expression of specific genes in the early 1990s. This resulted in the discovery of microRNAs (miRNAs), which are now known to exist in all forms of life. These molecules, it turns out, play vital functions in a variety of biological processes.

26 Apr 2023

Previously Unknown Protein Reveals RNA Repair Mechanism in Humans

Ribonucleic acids (RNAs) are single-stranded molecules that are found in all living organisms’ cells. As “transcripts” of human genes, mRNAs, for instance, play a role in the translation of genetic information by bearing the instructions for the production of a protein in their own sequence.

26 Apr 2023

Researchers Illuminate How Neurons Consume and Metabolize Glucose

The human brain has a sweet tooth, burning through nearly one quarter of the body's sugar energy, or glucose, each day.

21 Apr 2023

Molecular Mechanisms That Maintain the Tissue Specificity of PKMzeta

The protein PKMzeta has been strongly associated with long-term memory formation.

19 Apr 2023

The Function of ANKLE1 in the Prevention of DNA Damage and Autoimmunity

The University of Hong Kong (HKU) School of Biological Sciences research team led by Dr. Gary Ying Wai Chan has uncovered the function of a unique enzyme called ANKLE1.

19 Apr 2023

Leveraging Advanced Genomic Approaches for Amphibian Conservation

Morris Animal Foundation and Revive & Restore recently announced the funding of five new projects building genomic tools for amphibian conservation.

18 Apr 2023

Genetic Changes Affecting Cartilage Cell Maturation may Influence Adult Height, Study Shows

When it comes to height, our fate is sealed along with our growth plates—cartilage near the ends of bones that hardens as a child develops.

17 Apr 2023

Optimized Genome-Editing Method Vastly Reduces Mutations

CRISPR-Cas9 is frequently used to alter the genome by researching and editing disease-related genes. However, this approach is coupled with undesirable side effects including mutations and toxicity.

11 Apr 2023

CRISPR-Cas9 Driven Gene-Editing Tool Models Liver Cancer Tumor Subtypes

Mutations in human genes can cause serious issues, such as colon or liver cancer. However, cancer is a very complex condition. Mutations in the same genes can result in distinct kinds of cancers in different persons.

11 Apr 2023

The Modified Development Potential of Worm Embryonic Cells

A startling discovery that challenges the conventional wisdom that the majority of the hereditary information for cell differentiation is encoded within DNA and other genetic factors has been made regarding how specific proteins within the chromosomes of roundworms facilitate their offspring to develop specialized cells generations later.

10 Apr 2023