Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Breakthrough Study Reveals How Toxoplasma gondii Alters Host Cell Metabolism

Toxoplasma gondii is a parasite responsible for toxoplasmosis, a lifelong chronic infection prevalent in about 30% of the human population.

12 Jul 2024

UQ Researchers Reveal Mechanism of Immune Evasion by Haemophilus influenzae

Researchers from The University of Queensland have identified how a common bacterium is able to manipulate the human immune system during respiratory infections and cause persistent illness.

12 Jul 2024

New Insights into ILC2 Development Could Lead to Innovative Therapies for Allergic Diseases

Scientists have discovered a novel mechanism of ILC2 immune cell development which may be involved in exacerbating allergic diseases.

11 Jul 2024

UNC-Chapel Hill Study Reveals New Mechanism of Gene Regulation Beyond Histone Modification

University of North Carolina at Chapel Hill researchers have determined whether a specific chemical modification of a protein that packages the genome called a histone affects gene activity and cell proliferation according to the paper, "Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation," published in Genes & Development.

11 Jul 2024

Real-Time Snapshots of RNA Polymerase Illuminate Transcription Bubble Dynamics

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA.

10 Jul 2024

Small Molecules Offer Precise Control Over Splicing in Gene Expression

The correct functioning of cells relies heavily on the ability to finely control gene expression, a complex process by which the information contained in DNA is copied into RNA to eventually give rise to all the proteins and most of the regulatory molecules in the cell.

3 Jul 2024

AI Uncovers Cancer Drivers in Non-Coding DNA

Researchers at the Garvan Institute have discovered putative drivers of cancer concealed in so-called "junk" DNA regions, creating opportunities for novel approaches to diagnosis and treatment using artificial intelligence.

3 Jul 2024

Study Reveals Epigenetic Changes in Sperm from Non-Genetic Infertility Causes

How non-genetic factors can induce epigenetic modifications to the sperm and cause male infertility.

3 Jul 2024

Enhancing Precision and Versatility in Genetic Sensor Design

Genetic sensors play a crucial role within organisms by regulating gene expression in response to environmental stimuli.

2 Jul 2024

Genome Assembly of Finger Lemon 'YaoJi' Reveals Genetic Underpinnings of Rind Color Differences

A research team successfully sequenced and assembled the genome of the purple finger lemon variety 'YaoJi', revealing a genome size of 314.63 Mb across nine chromosomes.

28 Jun 2024

Study Highlights MSC-EVs Potential for Alleviating Lung Fibrosis

Pulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation, causing structural damage and lung failure.

27 Jun 2024

Histone H3K9 Methylation Found to Act as a Dimmer Switch for Gene Regulation

Researchers led by Kannosuke Yabe, Asuka Kamio, and Soichi Inagaki of the University of Tokyo have discovered that in thale cresses histone H3 lysine-9 (H3K9) methylation, conventionally thought to be a mark of turning off gene transcription, can also turn on gene expression via the interactions of two other proteins and histone marks.

27 Jun 2024

One Size Doesn't Fit All: Study Reveals Stark Sex Differences in Mitochondrial Activity

Study comparing the genetic activity of mitochondria, the cell’s power plants, in males and females finds extreme differences, suggesting certain disease therapies must be tailored to each sex.

26 Jun 2024

Unlocking the Secrets of Aging Brains

Researchers have determined the potential mechanisms through which some long-lived mutants of the Caenorhabditis elegans model system experience cognitive decline and others can retain learning and memory into old age.

26 Jun 2024

Scientists Identify Gene Region that Fuels Asthma Inflammation

Pollen and house dust mites are two common allergens that cause respiratory distress in asthma patients. But type-2 helper T (Th2) cells and group-2 innate lymphoid cells (ILC2s) release a class of proteins known as type-2 cytokines in response to a variety of asthma triggers. GATA-binding protein 3 (GATA3) is essential for the maturation of Th2 and ILC2.

25 Jun 2024

CRISPR-Derived Protein Controls Exon Inclusion and Exclusion

The University of Toronto researchers have successfully and precisely controlled the process of RNA splicing by using CRISPR, a bacterial immune defense system.

25 Jun 2024

High-resolution 3D maps of diseased tissues at the subcellular level

Molecular maps from patient tissue samples can be created with subcellular precision using an open-source platform created by researchers in the lab of Nikolaus Rajewsky at the Max Delbrück Center. This allows for in-depth analysis and may improve routine clinical pathology. The research was published in the journal Cell.

25 Jun 2024