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Study investigates schizophrenia risk across African ancestry

Researchers have identified two previously unknown genes linked to schizophrenia and newly implicated a third gene as carrying risk for both schizophrenia and autism. Led by the Icahn School of Medicine at Mount Sinai, the multi-center study further demonstrated that the schizophrenia risk conferred by these rare damaging variants is conserved across ethnicities. The study may also point to new therapeutics.

14 Mar 2023

Chemical compound found in common tropical plant helps kill cancer cells

A scientific instrument at the Department of Energy's Oak Ridge National Laboratory could help create a noninvasive cancer treatment derived from a common tropical plant.

13 Mar 2023

Liver-produced hormone protects mice against the harmful effects of intoxication

A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn't receive this treatment, UT Southwestern researchers report in a new study.

8 Mar 2023

Regulatory T cells produced in the gut play a role in repairing injured muscles

The human immune system is incredibly versatile. Among its most skilled multitaskers are T cells, known for their role in everything from fighting infection to reining in inflammation to killing nascent tumors.

3 Mar 2023

Novel framework provides solutions to evade detoxification networks

Scientists at St. Jude Children's Research Hospital have demonstrated how drug makers can avoid two key problems: toxicity and resistance. The researchers made slight changes to a small molecule to reduce its metabolism and elimination by the cellular detoxification network regulated by the pregnane X receptor (PXR). This research provides a framework to develop solutions to the long-standing issue of how to evade detoxification networks using medicinal chemistry. The findings were published today in Proceedings of the National Academy of Sciences.

1 Mar 2023

CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System

CN Bio, a leading Organ-on-a-Chip (OOC) company that designs and manufactures single-and multi-organ microphysiological systems (MPS), today announced the commercial launch of the PhysioMimix™ Single-organ Higher Throughput (HT) System.

From CN Bio Innovations Limited 28 Feb 2023

Study: Oral verapamil improves the pancreas' insulin secretion in children with newly-diagnosed TID

Published in JAMA, a University of Minnesota led study shows that verapamil, a drug commonly used to treat high blood pressure and heart conditions, can have a beneficial effect on the pancreas in children with newly-diagnosed type 1 diabetes (T1D).

27 Feb 2023

Researchers tease apart the molecular components involved in abdominal aneurysms

When the artery that supplies the stomach and the liver forms a bulge that ruptures, this medical emergency results in the deaths of 50 percent of patients before they reach the hospital.

24 Feb 2023

Robust method for induced pluripotent stem cell culture

Different types of cells, such as the heart, liver, blood, and sperm cells, have characteristics that help them perform their specific functions in the body. In general, those traits are hard-wired. A heart cell will not randomly transform into a liver cell if not stimulated.

23 Feb 2023

Mount Sinai researchers reveal mechanisms underlying autoimmunity in Down syndrome

Scientists at the Icahn School of Medicine at Mount Sinai in New York have identified which parts of the immune system go awry and contribute to autoimmune diseases in individuals with Down syndrome.

23 Feb 2023

Mount Sinai researchers illuminate the role of DNA methylation in Alzheimer's disease

Mount Sinai researchers have published a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the role of DNA methylation in Alzheimer's disease (AD).

23 Feb 2023

Iron-dependent cell death can be used to improve immunotherapies against liver cancer

Iron-dependent cell death (ferroptosis) is a type of programmed cell death by means of which the body kills off diseased, defective or superfluous cells.

20 Feb 2023

Revealing a novel form of ferroptosis that may be implicated in diseases caused by acute injury

This study is led by Dr. Anjian Xu (Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University), Dr. Min Cong (Liver Research Center, Beijing Friendship Hospital, Capital Medical University) and Dr. Junying Ding (Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University).

20 Feb 2023

New software helps identify genes that play vital roles in the development

Computer software developed at Washington University School of Medicine in St. Louis can predict what happens to complex gene networks when individual genes are missing or dialed up more than usual.

14 Feb 2023

Review highlights the pathological significance of CEACAM1, 5, and 6

A new review was published in Genes & Cancer on February 1, 2023, entitled, "CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens."

14 Feb 2023

Research reveals gene expression changes in two brain regions of individuals with cocaine use disorder

Individuals with cocaine use disorder exhibit gene expression changes in two brain regions: the nucleus accumbens, a region associated with reward, and the caudate nucleus, a region mediating habit formation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published February 10 in Science Advances.

13 Feb 2023

Prolonged alcohol use and its detrimental effects on blood protein snapshot

Jon Jacobs, a biochemist, has examined the blood of people suffering from diseases including Ebola, cancer, TB, hepatitis, diabetes, Lyme disease, brain damage, and influenza.

10 Feb 2023

UVA researchers discover a key trigger for common liver disease

University of Virginia School of Medicine researchers have discovered a key trigger for non-alcoholic fatty liver disease, a mysterious condition that causes fat to build up in the liver for no clear reason.

10 Feb 2023

Technology development could help expand usefulness of Raman microscopy

Researchers have developed a Raman microscope that can acquire information hundreds of times faster than a conventional Raman microscope.

8 Feb 2023

Macrophages as new therapeutic target to address obesity-related diseases

Macrophages are immune system cells that control inflammation and tissue function in addition to being crucial in the early response to microbial infection. Since it aids in the repair of damaged tissue, inflammation is a natural physiological response.

6 Feb 2023

Liver News and Research

Study investigates schizophrenia risk across African ancestry

Chemical compound found in common tropical plant helps kill cancer cells

Liver-produced hormone protects mice against the harmful effects of intoxication

Regulatory T cells produced in the gut play a role in repairing injured muscles

Novel framework provides solutions to evade detoxification networks

CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System

Study: Oral verapamil improves the pancreas' insulin secretion in children with newly-diagnosed TID

Researchers tease apart the molecular components involved in abdominal aneurysms

Robust method for induced pluripotent stem cell culture

Mount Sinai researchers reveal mechanisms underlying autoimmunity in Down syndrome

Mount Sinai researchers illuminate the role of DNA methylation in Alzheimer's disease

Iron-dependent cell death can be used to improve immunotherapies against liver cancer

Revealing a novel form of ferroptosis that may be implicated in diseases caused by acute injury

New software helps identify genes that play vital roles in the development

Review highlights the pathological significance of CEACAM1, 5, and 6

Research reveals gene expression changes in two brain regions of individuals with cocaine use disorder

Prolonged alcohol use and its detrimental effects on blood protein snapshot

UVA researchers discover a key trigger for common liver disease

Technology development could help expand usefulness of Raman microscopy

Macrophages as new therapeutic target to address obesity-related diseases

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