Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Medicines Discovery Catapult relaunches Wolfson Radiochemistry facility in Manchester

Medicines Discovery Catapult (MDC) today announces the relaunch of radiochemistry at the Wolfson Molecular Imaging Centre (WMIC) in Manchester.

5 Aug 2021

Study highlights novel approach for designing anti-viral drugs

Scientists are exploring a novel screening approach that concentrates on the recognition of virus-specific morphological changes in virus-infected cells.

4 Aug 2021

Next generation automation lab achieves huge productivity gains

Eli Lilly and Company and their industry partners, including sample management specialists – Ziath, are speeding the discovery of new medicines through the fully automated Lilly Life Sciences Studio lab in San Diego, USA.

From Ziath Ltd 30 Jul 2021

Researchers develop a cost-effective and versatile approach for drug synthesis

Different factors influence the cost-effectiveness of drug synthesis, the amount of waste generated being one of those.

29 Jul 2021

Already characterized active substances exhibit unexpected effects

Every innovative drug starts with the search for an active substance targeting key players in disease-related processes.

23 Jul 2021

Study identifies many small molecules that bind to certain areas of the SARS-CoV-2 genome

Scientists at Goethe University have now identified some regions of the SARS-CoV-2 genome that might be an ideal target for future drugs.

21 Jul 2021

Researchers use body-on-a-chip cancer models to study personalized immunotherapy response

Wake Forest researchers and clinicians are using patient-specific tumor 'organoid' models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, one of the rarest cancers affecting only 1 in 100,000 people.

20 Jul 2021

$Microcrystal electron diffraction could help obtain potential pharmaceutical structures$

Microcrystal electron diffraction could help obtain potential pharmaceutical structures

In the process of drug development, solving structures of potential therapeutics with X-ray diffraction (XRD) has been a presumed, critical step so far.

16 Jul 2021

Researchers develop novel technique to control tiny water droplets in lab-on-a-chip applications

Scientists develop a method to better manipulate tiny droplets in lab-on-a-chip applications for biochemistry, cell culturing, and drug screening.

12 Jul 2021

Deep machine learning adds to the knowledge of one million molecules’ bioactivity

The Structural Bioinformatics and Network Biology team at IRB Barcelona has developed a tool that predicts the biological activity of chemical compounds.

30 Jun 2021

WEHI partners with Boehringer Ingelheim to develop novel anti-cancer therapeutics

WEHI has partnered with Boehringer Ingelheim, a leading research-driven pharmaceutical company, in a collaboration to discover and develop anti-cancer therapeutics using a promising new technology called targeted protein degradation.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 25 Jun 2021

Gene therapy may be a safe and effective single-dose treatment for hypophosphatasia

A preclinical study led by scientists at Sanford Burnham Prebys has established that AAV8-TNAP-D10--a gene therapy that replaces a key enzyme found in bone--may be a safe and effective single-dose treatment for hypophosphatasia (HPP).

8 Jun 2021

NIH grant awarded to model and analyze protein-ligand interactions in cancer research

Computer scientist Lydia Kavraki of Rice University's Brown School of Engineering has won a prestigious National Institutes of Health U01 grant to develop a new approach to model and analyze protein-ligand interactions in cancer research.

8 Jun 2021

New process reinvigorates the search for natural drugs to treat cancers

A research team has devised a new method that might revitalize the hunt for natural product medications to treat viral infections, cancer, and other diseases.

4 Jun 2021

Researchers discover dramatic changes in the chemistry and composition of Sargassum

For centuries, pelagic Sargassum, floating brown seaweed, have grown in low nutrient waters of the North Atlantic Ocean, supported by natural nutrient sources like excretions from fishes and invertebrates, upwelling and nitrogen fixation.

24 May 2021

Human self-organizing cardiac organoids mimic the architecture of a heart chamber

Self-organizing heart organoids created at the Austrian Academy of Sciences’ Institute of Molecular Biotechnology (IMBA) are also efficient injury and in vitro congenital disease models. These “cardioids” have the potential to transform studies into cardiovascular diseases and heart malformations.

21 May 2021

Drug Discovery News and Research

Further Reading

Medicines Discovery Catapult relaunches Wolfson Radiochemistry facility in Manchester

Study highlights novel approach for designing anti-viral drugs

Next generation automation lab achieves huge productivity gains

Researchers develop a cost-effective and versatile approach for drug synthesis

Already characterized active substances exhibit unexpected effects

Study identifies many small molecules that bind to certain areas of the SARS-CoV-2 genome

Researchers use body-on-a-chip cancer models to study personalized immunotherapy response

Microcrystal electron diffraction could help obtain potential pharmaceutical structures

Researchers develop novel technique to control tiny water droplets in lab-on-a-chip applications

Deep machine learning adds to the knowledge of one million molecules’ bioactivity

WEHI partners with Boehringer Ingelheim to develop novel anti-cancer therapeutics

Gene therapy may be a safe and effective single-dose treatment for hypophosphatasia

NIH grant awarded to model and analyze protein-ligand interactions in cancer research

New process reinvigorates the search for natural drugs to treat cancers

Researchers discover dramatic changes in the chemistry and composition of Sargassum

Human self-organizing cardiac organoids mimic the architecture of a heart chamber

Photosynthesis of Chiral Building Blocks for Drug Discovery

New, patented method helps drugs to easily enter the cells

New CAD technology may open up new frontiers in genome research

AI-based software for automatic tracking of cells in microscope videos

eBook: Essential Guide to Organoids for Drug Discovery Applications eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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