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How RNA Regulates Gene Silencing Could Pave Way for Novel Cancer Therapies

Deep inside our cells-;each one complete with an identical set of genes-;a molecular machine known as PRC2 plays a critical role in determining which cells become heart cells, versus brain or muscle or skin cells.

27 Sep 2023

Scientists Develop Molecular Radar to Detect Active Cullin-RING Ligases

Our cells have a fleet of 300 molecular machines, called cullin-RING ligases, or "CRLs" for short, that each is capable of triggering destruction of specific proteins for the well-being of our cells.

27 Sep 2023

Discovering the Key Molecule Involved in Bacterial Locomotion

A research team led by Professor Emeritus Michio Homma and Professor Seiji Kojima from the Graduate School of Science at Nagoya University, in partnership with Osaka University and Nagahama Institute of Bio-Science and Technology, has gained fresh insights into the mechanism of bacterial locomotion.

20 Sep 2023

Revealing How Copper Amine Oxidase Enzymes Stabilize Radical Intermediates

The human body heals wounds or detoxifies harmful substances like histamine with the help of a group of enzymes called copper amine oxidases.

20 Sep 2023

New Device Mimics Biology to Detect Disease

In living organisms, cells have a very high capacity to process and communicate information by moving molecules or ions through tiny channels that span the cell membrane. UC Santa Cruz Professor of Electrical and Computer Engineering Marco Rolandi's lab and collaborators at MIT have created a device that mimics this biological concept in order to detect disease.

19 Sep 2023

Scientists Discover New Pathway for Biosynthesis of Cardenolides in Plants

Scientists at the Max Planck Institute for Chemical Ecology in Jena are investigating the previously largely unknown biosynthetic pathway that leads to the formation of cardenolides in plants.

19 Sep 2023

Lipidome Study Reveals New Insights Into Human Health

The sequencing of the human genome promised a revolution in medicine, but scientists soon realized that a genetic blueprint alone does not show the body in action.

12 Sep 2023

New Mechanism Underpins Paternal Methylation Imprinting

Scientists at the Van Andel Institute and its partners have discovered a critical component of a system that annotates genetic information before it is transferred from fathers to their offspring.

7 Sep 2023

Targeted MicroRNA-34a Therapy Shows Promise in Slowing Tumor Growth in Mice

A new cancer therapy developed by Purdue University researchers attacks tumors by tricking cancer cells into absorbing a snippet of RNA that naturally blocks cell division.

5 Sep 2023

Intellegens and CPI Awarded £1.6 m Innovate UK Grant to Advance Manufacture of Oligonucleotide Therapeutics with Machine Learning

Intellegens today announced that it has secured a £1.6 m grant from Innovate UK, part of UK Research and Innovation (UKRI), to apply ML in the emerging field of oligonucleotide therapies.

From Intellegens Limited 30 Aug 2023

Study Reports High-Resolution Structures of CAF-1

Since the passage of the DNA replication fork destroys nucleosomes on the DNA, chromatin inheritance during cell division requires the replication of DNA and the assembling of nucleosomes onto the duplicated DNA.

28 Aug 2023

DNA Data Storage: The Next Frontier in Computer Technology

The hereditary molecule DNA can store a great deal of information over long periods of time in a very small space. For a good ten years, scientists have therefore been pursuing the goal of developing DNA chips for computer technology, for example for the long-term archiving of data.

25 Aug 2023

Scientists Uncover New Mechanism for Degrading Short-Lived Proteins

Short-lived proteins control gene expression in cells to carry out a number of vital tasks, from helping the brain form connections to helping the body mount an immune defense. These proteins are made in the nucleus and are quickly destroyed once they've done their job.

25 Aug 2023

A Newly Discovered Plant Gene that Helps Make Apiin: The Search Ends Here

Apiin, a natural compound found in high amounts in parsley and celery, is thought to have important medicinal properties.

24 Aug 2023

A Colonizing Strategy of Salmonella Gut Bacteria

According to researchers at ETH Zurich, when the gut is already populated by a closely similar strain of Salmonella bacteria, it only requires the capacity to use a single other food source for the bacteria to flourish.

22 Aug 2023

From Neanderthals to New Drugs: Unlocking Ancient Proteins

We need to think big in antibiotics research.

17 Aug 2023

Targeting Long-read RNA Sequencing with Low-Cost Technology

Researchers at the Children’s Hospital of Philadelphia (CHOP) have created a flexible and affordable approach for targeted sequencing of full-length RNA molecules, which might hasten the development of novel diagnostics and therapies.

16 Aug 2023

AI Tool Speeds Up Vaccine Development

From tackling homework challenges to drafting emails, people are discovering a vast array of applications for natural language processing tools like generative artificial intelligence (AI) engines.

14 Aug 2023

Newly Developed Antibody Therapy to Have Benefits Over Existing Opioid-Overdose Treatments

An antibody in single-chain fragment variable (scFv) format that binds to the powerful opioid carfentanil was shown to reverse signs of carfentanil overdose in preclinical tests conducted by scientists at Scripps Research.

11 Aug 2023

Researchers Lead Innovative Studies on Mammalian Aging and Life Span

Scientists at UCLA David Geffen School of Medicine and UCLA Health led an international research team that published two articles detailing changes in DNA – changes that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits.

11 Aug 2023