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Stress response in mom leads to epigenetic change in children

Adding evidence to the importance of early development, a new study links neutral maternal behavior toward infants with an epigenetic change in children related to stress response.

2 Mar 2023

Novel framework provides solutions to evade detoxification networks

Scientists at St. Jude Children's Research Hospital have demonstrated how drug makers can avoid two key problems: toxicity and resistance. The researchers made slight changes to a small molecule to reduce its metabolism and elimination by the cellular detoxification network regulated by the pregnane X receptor (PXR). This research provides a framework to develop solutions to the long-standing issue of how to evade detoxification networks using medicinal chemistry. The findings were published today in Proceedings of the National Academy of Sciences.

1 Mar 2023

Lieber Institute awarded $1 million grant to foster racial diversity across neuroscience

The Lieber Institute for Brain Development has received a $1 million, two-year grant from the Chan Zuckerberg Initiative to support the work of the African Ancestry Neuroscience Research Initiative (AANRI) to promote racial equity throughout the field of neuroscience.

28 Feb 2023

Redefining low-risk WNT-pathway medulloblastoma based on newer biological information

A new research perspective was published in Oncotarget's Volume 14 on February 7, 2023, entitled, "WNT-pathway medulloblastoma: what constitutes low-risk and how low can one go?"

28 Feb 2023

Voluntary initiatives to promote the replacement of lead in UK game hunting are not very effective

Three years into a five-year pledge to completely phase out lead shot in UK game hunting, a Cambridge study finds that 94% of pheasants on sale for human consumption were killed using lead.

27 Feb 2023

Study: Oral verapamil improves the pancreas' insulin secretion in children with newly-diagnosed TID

Published in JAMA, a University of Minnesota led study shows that verapamil, a drug commonly used to treat high blood pressure and heart conditions, can have a beneficial effect on the pancreas in children with newly-diagnosed type 1 diabetes (T1D).

27 Feb 2023

Discovery of a lung stem cell subset provides opportunity for new COPD treatments

Respiratory viral infections pose significant morbidity and mortality to patients with chronic lung diseases like emphysema and COPD, causing exacerbations that drive destruction of normal lung tissue, and leading to one of the most common diagnoses for hospital admissions.

24 Feb 2023

Prototype treatment shows great potential in neutralizing snake toxins from multiple species

Prototype treatment for snake bite envenoming proves effective against the venom of African and Asian elapid snakes, such as some cobra, mamba, and krait species, new research shows.

24 Feb 2023

Study uncovers differences in how AstraZeneca and Pfizer COVID-19 vaccines affect the immune system

A new Australian study led by SAHMRI and Flinders University has uncovered fundamental differences in how the AstraZeneca and Pfizer COVID-19 vaccines impact the immune system.

23 Feb 2023

Study identifies genetic variants linked to mathematical abilities in children

A new study published in Genes, Brain and Behavior has identified several genetic variants that may be linked with mathematical abilities in children.

23 Feb 2023

LMU physician explores the causes of high susceptibility to deadly infections in prematurely born babies

LMU physician Markus Sperandio has discovered why the immune system of prematurely born babies is not working properly after birth.

23 Feb 2023

Novel model system helps studying human ovarian biology

Despite the fact that we all start out as an egg cell in one of our mother's ovaries, these human reproductive organs are surprisingly under-studied. Scientists have been working on creating in vitro models of human ovaries so that we can learn more about them and develop treatments for ovarian conditions, but most existing models use a combination of human and mouse cells, which do not faithfully replicate human ovary functions and take a long time to grow in the lab.

22 Feb 2023

Scientists correct limb length in mouse model of autosomal dominant Robinow Syndrome

Robinow Syndrome is the best known of a set of genetic disorders that affect the growth and development of the skeletal system.

16 Feb 2023

LJI receives funding from NIAID to lead the biggest human immunoprofiling effort

A new grant of over $17 million from the National Institute of Allergy and Infectious Diseases (NIAID) has established La Jolla Institute for Immunology (LJI) as the leading institute for human immunology data curation, analysis, and dissemination. With this funding, LJI has taken the helm of the Human Immunology Project Consortium Data Coordinating Center, a critical tool in the effort to fuel scientific collaboration in immunoprofiling and highlight findings from the overall Human Immunology Project Consortium (HIPC).

16 Feb 2023

Tackling child undernutrition by targeting the gut microbiome

According to research conducted by the Queen Mary University of London, nutritional interventions used to combat child undernutrition in low and middle-income countries should focus on gut microbiome development instead of just human nutritional needs in an attempt to improve child growth and development more efficaciously.

15 Feb 2023

IGSF3-mediated potassium dysregulation drives glioma-related epilepsy

Glioma is one of the most aggressive malignant primary brain tumors. A common feature of glioma is the presence of localized, intermittent seizures referred to as glioma-related epilepsy, which is known to promote tumor growth. However, the mechanism involved at the molecular level is still not clear.

15 Feb 2023

Children News and Research

Stress response in mom leads to epigenetic change in children

Novel framework provides solutions to evade detoxification networks

Lieber Institute awarded $1 million grant to foster racial diversity across neuroscience

Redefining low-risk WNT-pathway medulloblastoma based on newer biological information

Voluntary initiatives to promote the replacement of lead in UK game hunting are not very effective

Study: Oral verapamil improves the pancreas' insulin secretion in children with newly-diagnosed TID

Discovery of a lung stem cell subset provides opportunity for new COPD treatments

Prototype treatment shows great potential in neutralizing snake toxins from multiple species

Study uncovers differences in how AstraZeneca and Pfizer COVID-19 vaccines affect the immune system

Study identifies genetic variants linked to mathematical abilities in children

LMU physician explores the causes of high susceptibility to deadly infections in prematurely born babies

Novel model system helps studying human ovarian biology

Scientists correct limb length in mouse model of autosomal dominant Robinow Syndrome

LJI receives funding from NIAID to lead the biggest human immunoprofiling effort

Tackling child undernutrition by targeting the gut microbiome

IGSF3-mediated potassium dysregulation drives glioma-related epilepsy

3D structure of a major protein complex in cilia revealed

Study finds similar levels of DNA damage in vapers and smokers

New software helps identify genes that play vital roles in the development

Rare disease involving speech and motor coordination difficulties identified

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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