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New type of cancer immunotherapy trains the immune system to eliminate tumor cells

A groundbreaking new type of cancer immunotherapy developed at the Icahn School of Medicine at Mount Sinai trains the innate immune system to help it eliminate tumor cells through the use of nanobiologics, tiny materials bioengineered from natural molecules that are paired with a therapeutic component, according to a study published in Cell in October.

2 Nov 2020

“Nanobiologic” immunotherapy can train the immune system to eliminate tumor cells

Until recently, it was believed that the innate immune system, the body's first line of defense, lacked the ability to remember pathogens like the adaptive immune system.

2 Nov 2020

Researchers identify genes associated with autism spectrum disorder

The lack of some genes in the BEC/TCEAL cluster could be related to some alterations associated with the autism spectrum disorder, according to a preclinical study published in the journal Genome Biology, and led by Professor Jordi Garcia Fernàndez, from the Faculty of Biology and the Institute of Biomedicine of the University of Barcelona (IBUB), and researcher Jaime Carvajal, from the Andalusian Centre for Developmental Biology - University Pablo de Olavide (CSIC-UPO).

27 Oct 2020

Study sheds light on the ability of melanomas to form early metastases

Research led by Queen Mary University of London has revealed novel insights into the mechanisms employed by melanoma cells to form tumours at secondary sites around the body.

21 Oct 2020

Immunotherapy using CAR NKT cells shows promise for treating solid tumors

Natural killer T (NKT) cells, a type of immune cells known for their potent anti-cancer properties in murine tumor models, have been developed into a novel form of immunotherapy to treat patients with cancer.

14 Oct 2020

Enzyme SSH1 impairs disposal of damaged tau and mitochondria leaking toxins

In a healthy brain, the multistep waste clearance process known as autophagy routinely removes and degrades damaged cell components - including malformed proteins like tau and toxic mitochondria.

13 Oct 2020

Researchers test the effect of hydroxychloroquine versus favipiravir in SARS-CoV-2−infected hamsters

Virologists at the KU Leuven Rega Institute have been working on two lines of SARS-CoV-2 research: searching for a vaccine to prevent infection, and testing existing drugs to see which one can reduce the amount of virus in infected people.

12 Oct 2020

Researchers examine cooperative tumorigenic effects of targeted deletions of tumor suppressors

Volume 11, Issue 28 of Oncotarget features "Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice" by Xu et, al. which reported that the authors examined whether the TSGs Rb1, Trp53, Pten, and Men1 have cooperative effects in suppressing neuroendocrine tumors in mice.

12 Oct 2020

Developing a 'Trojan Horse' nanotherapy to fight breast cancer

With a nearly $2.6 million grant from the National Institutes of Health, Michigan State University researchers are using nanoscopic particles to turn the body's own cells into weapons that cancer won't see coming.

12 Oct 2020

Researchers uncover problems with the conventional method for growing organoids

Organoids are stem cell-based tissue surrogates that can mimic the structure and function of organs, and they have become a key component of numerous types of medical research in recent years.

1 Oct 2020

High-fiber diet can reduce radiation-induced gut inflammation, study shows

Loved or hated, the humble oat could be the new superfood for cancer patients as international research shows a diet rich in fiber could significantly reduce radiation-induced gut inflammation.

30 Sep 2020

Fine-tuning stem cell metabolism prevents hair loss

A team of researchers have discovered a mechanism that prevents hair loss: hair follicle stem cells.

29 Sep 2020

Cocaine addiction: Impact of genetic mutations elucidated

Cocaine addiction is a chronic disorder with a high rate of relapse for which no effective treatment is currently available.

28 Sep 2020

Researchers develop antibacterial agent to treat drug-resistant infections

Methicillin-resistant Staphylococcus aureus (MRSA) is the most lethal drug-resistant bacteria and is also one of the most common bacterial pathogens.

3 Sep 2020

Natural killer cells could be a powerful weapon for fighting lung cancer

Immune cells called 'natural killer' (NK) cells could be a powerful weapon for fighting lung cancer, according to Australian researchers.

2 Sep 2020

Study looks into safety and early outcomes of gene therapy for spinal muscular atrophy

In May 2019, the U.S. Food and Drug Administration (FDA) approved a gene replacement therapy for the inherited, progressive neuromuscular disease 5q-linked spinal muscular atrophy (SMA).

26 Aug 2020

Researchers add a component to make cancer vaccine more effective

Jefferson researchers developing a cancer vaccine to prevent recurrences of gastric, pancreatic, esophageal and colon cancers have added a component that would make the vaccine more effective.

25 Aug 2020

Gene targeting could lead to better treatment of glioblastoma tumors

New insight into a gene that controls energy production in cancer stem cells could help in the search for a more effective treatment for glioblastoma.

19 Aug 2020

Study sheds light on genetic and molecular mechanisms involved in atopic dermatitis

The KIF3A gene contains common variants that raise the risk of a dysfunctional skin barrier and ultimately lead to a skin condition, called atopic dermatitis.

17 Aug 2020

HPSC-based disease modeling can help treat heart diseases

A team of researchers has reported a article relating to human pluripotent stem cell-derived cardiomyocytes in the modeling and repair of heart disease.

11 Aug 2020

Preclinical News and Research

New type of cancer immunotherapy trains the immune system to eliminate tumor cells

“Nanobiologic” immunotherapy can train the immune system to eliminate tumor cells

Researchers identify genes associated with autism spectrum disorder

Study sheds light on the ability of melanomas to form early metastases

Immunotherapy using CAR NKT cells shows promise for treating solid tumors

Enzyme SSH1 impairs disposal of damaged tau and mitochondria leaking toxins

Researchers test the effect of hydroxychloroquine versus favipiravir in SARS-CoV-2−infected hamsters

Researchers examine cooperative tumorigenic effects of targeted deletions of tumor suppressors

Developing a 'Trojan Horse' nanotherapy to fight breast cancer

Researchers uncover problems with the conventional method for growing organoids

High-fiber diet can reduce radiation-induced gut inflammation, study shows

Fine-tuning stem cell metabolism prevents hair loss

Cocaine addiction: Impact of genetic mutations elucidated

Researchers develop antibacterial agent to treat drug-resistant infections

Natural killer cells could be a powerful weapon for fighting lung cancer

Study looks into safety and early outcomes of gene therapy for spinal muscular atrophy

Researchers add a component to make cancer vaccine more effective

Gene targeting could lead to better treatment of glioblastoma tumors

Study sheds light on genetic and molecular mechanisms involved in atopic dermatitis

HPSC-based disease modeling can help treat heart diseases

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