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Entry of Aging-Associated Enzymes into Human Genetic Material

An enzyme that controls aging and other metabolic processes accesses human genetic material to modify gene expression within the cell, according to a new study. Images of a sirtuin enzyme bound to a nucleosome, a tightly packed complex of DNA and proteins called histones, have been created by a team led by Penn State researchers.

17 Apr 2023

Identifying Lung Cancer Patients Who May Not Respond Well to Immunotherapy by MYC Gene Activation

Lung cancer patients who may not react well to immunotherapy (ICB) could be identified by the oncogenic activation of MYC, an important gene in the development of cancer.

17 Apr 2023

Researchers Show How a Virus can Induce Cleavage of Human Chromosome 11 to Cause Cancer

The Epstein-Barr virus (EBV) is easily spread through bodily fluids, primarily saliva, such as kissing, shared drinks or using the same eating utensils.

17 Apr 2023

Study Presents Crucial Themes in the Biology of Pancreatic Cancer

Scientists from the University of California, Irvine, the University of Michigan and the University of Texas MD Anderson Cancer Center have made a significant contribution to the field of pancreatic cancer research.

17 Apr 2023

Deletion of Specific Protein Creates a Hostile Environment for Aggressive Breast Tumors

Scientists at VCU Massey Cancer Center discovered that the deletion of a specific protein creates a hostile environment for tumor cells and significantly subdues breast cancer growth and spread.

13 Apr 2023

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer that often kills within a year of diagnosis. Surgery is almost impossible because of the tumors' location.

13 Apr 2023

A New, Cost-Effective Therapy to Treat a Wide Range of Cancers

A potential immunotherapy method for treating metastatic melanoma is adoptive cell therapy (ACT). The method, which utilizes the use of immune cells extracted from the patient’s own tumors, could offer cancer patients new options for treatment by eschewing radiation therapies and harsh chemotherapy drugs.

11 Apr 2023

Immunotherapy Response in Advanced Melanoma: Effect of Previous Treatments

According to a study conducted by UCLA, patients with advanced melanoma responded differently to PD-1 checkpoint blockade immunotherapy depending on a variety of variables, including whether or not they had previously received CTLA-4 blockade, another type of immunotherapy.

11 Apr 2023

CRISPR-Cas9 Driven Gene-Editing Tool Models Liver Cancer Tumor Subtypes

Mutations in human genes can cause serious issues, such as colon or liver cancer. However, cancer is a very complex condition. Mutations in the same genes can result in distinct kinds of cancers in different persons.

11 Apr 2023

New Epigenetic Vulnerability Of Acute Myeloid Leukemia Revealed

Acute myeloid leukemia (AML) is an aggressive blood cancer that causes uncontrolled accumulation of white blood cells. Because of the poor outcomes of this disease, researchers across the globe have been on the hunt for new ways to treat AML, while preserving normal blood development.

10 Apr 2023

Specialized Diet Stimulates a Unique Form of Programmed Cell Death

Glioblastoma is the most prevalent kind of adult brain tumor.

10 Apr 2023

Key Enzyme in Sugar Metabolism Plays Role in Protecting Cancer Cells

A key enzyme in sugar metabolism is inactivated particularly easily and efficiently by oxidative stress.

7 Apr 2023

Novel Protein Involved in Tumor Suppression Identified

Understanding how cancer develops is critical for designing effective, personalized cancer therapies. Researchers have known for years that cancer begins with mutations in certain types of genes.

7 Apr 2023

Enhancing Cancer Modeling with New Genetic Analysis Tool

Healthy food and exercise habits can have a big impact on a person’s general health. However, an individual’s genetics largely determines their chance of developing cancer.

5 Apr 2023

Gut Microbiome and Enhanced Tumor Immune Response in Pancreatic Cancer Survivors

Even as pancreatic cancer treatments advance, only around 9% of patients live beyond five years. Scientists have failed to identify genetic distinctions that explain why some patients live for a long time and others do not, so they have moved their emphasis to the gut microbiome.

5 Apr 2023

Experts Unravel the Crystal Structure of CENP-E

Anticancer drugs are essential in cancer treatment, but their toxicity is not always restricted to cancer cells, resulting in serious side effects.

5 Apr 2023

Role of Engineered E. coli in Sending Therapeutic Nanobodies to the Gut

Numerous bacterium types have taken up residence in humans. Currently, research is concentrated on genetically modifying these bacteria to increase their inherent therapeutic qualities.

5 Apr 2023

Insights into mechanisms impacting NSCLC disease progression

Proteomics is the study and analysis of proteins in a biological system, including their structures, functions, associations, and alterations.

5 Apr 2023

Jumping Genes in Various Cancers may be Used to Direct Novel Immunotherapies to Tumors

New research from Washington University School of Medicine in St. Louis suggests that transposable elements in various cancers potentially may be used to harness novel immunotherapies against tumors that don't typically respond to immune-based treatments. Shown is a 3D rendering of cancer cells.

4 Apr 2023

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.

3 Apr 2023

Tumor News and Research

Entry of Aging-Associated Enzymes into Human Genetic Material

Identifying Lung Cancer Patients Who May Not Respond Well to Immunotherapy by MYC Gene Activation

Researchers Show How a Virus can Induce Cleavage of Human Chromosome 11 to Cause Cancer

Study Presents Crucial Themes in the Biology of Pancreatic Cancer

Deletion of Specific Protein Creates a Hostile Environment for Aggressive Breast Tumors

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

A New, Cost-Effective Therapy to Treat a Wide Range of Cancers

Immunotherapy Response in Advanced Melanoma: Effect of Previous Treatments

CRISPR-Cas9 Driven Gene-Editing Tool Models Liver Cancer Tumor Subtypes

New Epigenetic Vulnerability Of Acute Myeloid Leukemia Revealed

Specialized Diet Stimulates a Unique Form of Programmed Cell Death

Key Enzyme in Sugar Metabolism Plays Role in Protecting Cancer Cells

Novel Protein Involved in Tumor Suppression Identified

Enhancing Cancer Modeling with New Genetic Analysis Tool

Gut Microbiome and Enhanced Tumor Immune Response in Pancreatic Cancer Survivors

Experts Unravel the Crystal Structure of CENP-E

Role of Engineered E. coli in Sending Therapeutic Nanobodies to the Gut

Insights into mechanisms impacting NSCLC disease progression

Jumping Genes in Various Cancers may be Used to Direct Novel Immunotherapies to Tumors

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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