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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Researchers demonstrate the impact of epithelial cells, mammary microenvironment on breast cancer cells

The cover for issue 30 of Oncotarget features Figure 4, "RNAseq results demonstrating differences between normal, cancer, and redirected cells," by Frank-Kamenetskii, et al. which reported that the influence of breast cancer cells on normal cells of the microenvironment, such as fibroblasts and macrophages, has been heavily studied but the influence of normal epithelial cells on breast cancer cells has not.

19 Oct 2020

Chemist receives NIH grant to provide new framework for novel flu vaccines

Chemist Mahmoud Moradi has received a $422,579 grant from the National Institutes of Health to advance his work modeling hemagglutinin, the critical protein of the influenza virus.

19 Oct 2020

New nanoparticles can destroy drug-resistant cancer cells

Multidrug resistance, or MDR, is a process in which tumors become impervious to numerous drugs and is a major cause of failure in cancer chemotherapy.

19 Oct 2020

Researchers identify “silent” mutations in the genetic code of COVID-19 virus

We know that the coronavirus behind the COVID-19 crisis lived harmlessly in bats and other wildlife before it jumped the species barrier and spilled over to humans.

19 Oct 2020

Study shows antibody levels drop rapidly in recovering COVID-19 patients

The lack of effective treatments for COVID-19 is forcing hospitals to use blood plasma from recovering patients to treat those who have severe symptoms.

19 Oct 2020

Researchers develop model to encode established biochemical principles at cellular level

The most important components for the functioning of a biological cell are its proteins. As a result, protein production is arguably the most important process for cell growth. The faster the bacterial growth rate, the faster protein synthesis needs to take place.

19 Oct 2020

CRISPR platform can accelerate potential treatment targets for SARS-CoV-2

Synthego has provided multiple CRISPR-based engineered cell lines to speed up the analysis of promising treatment targets for SARS-CoV-2.

19 Oct 2020

Small RNA molecule regulates the virulence factors of stomach bacteria

Over 50% of the global population carries the bacterium Helicobacter pylori in their stomach mucosa.

19 Oct 2020

New technology rapidly diagnoses sickle cell disease

Researchers at the University of Colorado Boulder and the University of Colorado Anschutz Medical Campus have developed a new way to diagnose diseases of the blood like sickle cell disease with sensitivity and precision and in only one minute.

16 Oct 2020

Krystal binding microplates set a new standard for uniform, reproducible capture of biomolecules

Porvair Sciences new medium and high bind Krystal microplates set a new standard for uniform and reproducible capture of a wide range of biomolecules ready for affinity binding assays such as ELISA's.

From Porvair Sciences Limited 16 Oct 2020

Synthetic signals could help control tissue regeneration

For a tiny embryo to develop into an adult organism, its cells must develop in precise patterns and interact with their neighbors in carefully orchestrated ways.

16 Oct 2020

Researchers discover how specific molecules promote cancer progression

The development of cancer is a highly complicated process, involving multiple genes and signaling pathways that become upregulated or downregulated throughout different stages of tumor growth and spread. Two of the most commonly altered genes in cancer are p53 and AKT.

16 Oct 2020

Researchers identify potential drugs that could be repurposed as pan-coronavirus treatments

A large international consortium of almost 200 researchers from 14 leading institutions in six countries has studied three different coronaviruses - SARS-CoV-1, SARS-CoV-2, and MERS-CoV - with the aim of finding vulnerabilities shared by these three pathogens.

16 Oct 2020

Peptide therapy prevents overreaction of the immune system against infections

Individuals require enough action to remove offensive viruses or bacteria, but not so much that their body suffer a considerable damage.

From UC San Diego 15 Oct 2020

Study provides new insights into molecular mechanisms of adipogenesis

The impairment of adipogenesis, the process in which fat cells (also known as adipocytes) accumulate to become fat tissue, can lead to many diseases such as diabetes, obesity, and heart conditions.

15 Oct 2020

Army researchers test alternative ways to measure COVID-19 antibody levels

Researchers with the U.S. Army Futures Command are part of a team that tested alternative ways to measure COVID-19 antibody levels, resulting in a process that is faster, easier and less expensive to use on a large scale. Their method holds promise for accurately identifying potential donors who have the best chance of helping infected patients through convalescent plasma therapy.

15 Oct 2020

Researchers assess heat-stress tolerance of different varieties of sweet potato

Climate change poses a threat to the world's subsistence crops. Heatwaves, which are likely to intensify according to climate evolution predictions, are generating levels of heat stress that are damaging to agricultural production.

15 Oct 2020

Scientists find sensor protein which enables normal functioning of bladder

A team co-led by scientists at Scripps Research has found that the main sensor protein enabling our sense of touch also underlies the feeling of having a full bladder and makes normal bladder function possible.

15 Oct 2020

Study offers renewed hope for children suffering from myofibrillar myopathies

Stephen Greenspan and Laura Zah were devastated when they learned their son Alexander had a rare genetic mutation, which causes a deadly neuromuscular disease with no known treatment or cure.

15 Oct 2020

DNA structural changes play key role in the recovery phase after DNA damage

A research team from Cologne has discovered that a change in the DNA structure - more precisely in the chromatin - plays a decisive role in the recovery phase after DNA damage. The key is a double occupation by two methyl groups on the DNA packaging protein histone H3 (H3K4me2).

15 Oct 2020