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pH comes from the term “power of Hydrogen”, or the hydrogen ion concentration present in a given solution. It helps to measure the acidity or alkalinity of a substance.

Experts unravel a vast network that shows how cells adjust in real-time to withstand stresses

Every minute of every day, our body adapts to meet the needs of each moment. When we binge on carbs, exercise, or become sick, chemical reactions inside our cells switch on, slow down, or shift strategy so that we have the energy and strength we need.

14 Mar 2023

Protecting normal cells from chemotherapy, while eliminating drug-resistant cancer cells

A new review paper was published in Oncotarget's Volume 14 on March 11, 2023, entitled, "Selective protection of normal cells from chemotherapy, while killing drug-resistant cancer cells."

14 Mar 2023

Understanding the relationship between gut microbiome and CAR T-cell therapy response

Microorganisms live in or on almost every part of the human body and play an important role in the regulation of normal human processes. As a result, changes in the number or type of microorganisms, also known as the microbiome, can contribute to disease and altered responses to therapy, including cancer treatment.

14 Mar 2023

Study identifies previously unknown cell types that drive the onset of osteoarthritis

A Michigan Medicine study has identified a new potential target for treating osteoarthritis – a debilitating joint disease that affects over 31 million Americans and is a leading cause of disability worldwide.

10 Mar 2023

Deeper understanding of T-cell responses may lead to better, more personalized immunotherapies

For the first time, a research team has identified and analyzed the steps by which immune cells "see" and respond to cancer cells, providing insights into reasons some treatments may be effective for certain patients but not others.

9 Mar 2023

“Bacterial suicide squad” recruits and activates innate and adaptive antitumor immune responses

Combining discoveries in cancer immunology with sophisticated genetic engineering, Columbia University researchers have created a sort of "bacterial suicide squad" that targets tumors, attracting the host's own immune cells to the cancer to destroy it. The new work, published today in Science Advances, marks a major step forward in efforts to enlist non-pathogenic bacteria to combat cancer.

9 Mar 2023

Liver-produced hormone protects mice against the harmful effects of intoxication

A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn't receive this treatment, UT Southwestern researchers report in a new study.

8 Mar 2023

LDL-mediated nanoparticle drug delivery could potentially circumvent high-grade gliomas

New research has shown that the blood vessels that feed aggressive brain tumors have receptors that could allow a new type of drug-containing nanoparticle to be used to starve the tumors of the energy they use to grow and spread, and also cause other disruptions to their adapted existence, even killing themselves.

8 Mar 2023

AI tool can accurately identify normal and abnormal chest X-rays in a clinical setting

An artificial intelligence tool can accurately identify normal and abnormal chest X-rays in a clinical setting, according to a study published in Radiology, a journal of the Radiological Society of North America.

8 Mar 2023

Study pinpoints a key cause of metastasis from an aggressive form of pediatric brain cancer

New research pinpoints a key cause of metastasis from an aggressive form of brain cancer in children and provides a potential new therapy for treating these tumors in the future.

7 Mar 2023

Applying crocodile’s unique pH sensing mechanism to benefit humans

Researchers from La Trobe University have just discovered how crocodiles, despite living in dirty water, prevent deadly fungal infections by employing a unique pH sensing mechanism.

3 Mar 2023

Novel framework provides solutions to evade detoxification networks

Scientists at St. Jude Children's Research Hospital have demonstrated how drug makers can avoid two key problems: toxicity and resistance. The researchers made slight changes to a small molecule to reduce its metabolism and elimination by the cellular detoxification network regulated by the pregnane X receptor (PXR). This research provides a framework to develop solutions to the long-standing issue of how to evade detoxification networks using medicinal chemistry. The findings were published today in Proceedings of the National Academy of Sciences.

1 Mar 2023

RNA modification plays a vital role in TDP-43-related neurodegeneration in ALS

Nearly 100% of cases of amyotrophic lateral sclerosis-the progressive, fatal neurodegenerative disease known as ALS or Lou Gherig's disease-involve the buildup of a protein called TDP-43.

28 Feb 2023

Lieber Institute awarded $1 million grant to foster racial diversity across neuroscience

The Lieber Institute for Brain Development has received a $1 million, two-year grant from the Chan Zuckerberg Initiative to support the work of the African Ancestry Neuroscience Research Initiative (AANRI) to promote racial equity throughout the field of neuroscience.

28 Feb 2023

Deep-learning approach to achieve faster and high-resolution photoacoustic computed tomography

It takes a few moments for the sound of thunder to reach our ears after a flash of lightning. This phenomenon is due to the photoacoustic (PA) effect where materials near the lightning instantly expand as the optical energy of the lightning is absorbed and converted into thermal energy.

24 Feb 2023

Study sheds light on unique processes that bestow naked mole-rats’ with eternal fertility

Unlike humans and other mammals, which become less fertile with age, naked mole-rats can reproduce throughout their remarkably long lifespans.

22 Feb 2023

Novel model system helps studying human ovarian biology

Despite the fact that we all start out as an egg cell in one of our mother's ovaries, these human reproductive organs are surprisingly under-studied. Scientists have been working on creating in vitro models of human ovaries so that we can learn more about them and develop treatments for ovarian conditions, but most existing models use a combination of human and mouse cells, which do not faithfully replicate human ovary functions and take a long time to grow in the lab.

22 Feb 2023

pH News and Research

Further Reading

Experts unravel a vast network that shows how cells adjust in real-time to withstand stresses

Protecting normal cells from chemotherapy, while eliminating drug-resistant cancer cells

Understanding the relationship between gut microbiome and CAR T-cell therapy response

Study identifies previously unknown cell types that drive the onset of osteoarthritis

Deeper understanding of T-cell responses may lead to better, more personalized immunotherapies

“Bacterial suicide squad” recruits and activates innate and adaptive antitumor immune responses

Liver-produced hormone protects mice against the harmful effects of intoxication

LDL-mediated nanoparticle drug delivery could potentially circumvent high-grade gliomas

AI tool can accurately identify normal and abnormal chest X-rays in a clinical setting

Study pinpoints a key cause of metastasis from an aggressive form of pediatric brain cancer

Applying crocodile’s unique pH sensing mechanism to benefit humans

Novel framework provides solutions to evade detoxification networks

RNA modification plays a vital role in TDP-43-related neurodegeneration in ALS

Lieber Institute awarded $1 million grant to foster racial diversity across neuroscience

Deep-learning approach to achieve faster and high-resolution photoacoustic computed tomography

Study sheds light on unique processes that bestow naked mole-rats’ with eternal fertility

Novel model system helps studying human ovarian biology

New technique uses amino acids to cure meat and poultry products

Scientists unravel the secrets of polydopamine coatings

Betalain-tomatoes confer anti-inflammatory effects against macrophages and murine colitis

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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