therapeutics News and Research

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Accelerating the structure-guided discovery of chemogenetic tools

In order to more fully understand how diseases arise in the brain, scientists must unravel the intricate way neurons relay messages (either chemical or electrical) along a complex web of nerve cells. One way is by using a tool called DREADDs, which stands for Designer Receptors Activated by Designer Drugs.

21 Feb 2023

LLNL set off to develop vaccines to treat rheumatoid arthritis and lupus

People afflicted with autoimmune diseases may someday receive help through treatments now under development by a Lawrence Livermore National Laboratory (LLNL) licensee and its' collaborations with two major pharmaceutical companies.

19 Feb 2023

Location is the key for psychedelic drugs to work

Location, location, location is the key for psychedelic drugs that could treat mental illness by rapidly rebuilding connections between nerve cells.

17 Feb 2023

An innovative strategy for on-demand contraception for men

An experimental contraceptive drug developed by Weill Cornell Medicine investigators temporarily stops sperm in their tracks and prevents pregnancies in preclinical models. The study, published in Nature Communications on Feb. 14, demonstrates that an on-demand male contraceptive is possible.

16 Feb 2023

New family of pharmaceutical compounds that target RNA

In Jennifer Hines’ lab, a group of graduate and undergraduate chemistry students recently discovered a new family of compounds that can target RNA and interfere with its function. In the future, RNA-targeted treatments to treat cancer and metabolic diseases, together with bacterial and viral infections, could be developed using the chemical scaffold found in this research.

15 Feb 2023

Study reveals how two proteins enable drug-resistant MRSA bacterium to secrete toxins

Antimicrobial resistance represents one of the top 10 global public health threats according to the World Health Organization, and scientists have been scrambling to find new tools to cure the most deadly drug-resistant infections.

14 Feb 2023

Study explains why cancers stop responding to kinase inhibitors and come back stronger

More than 70 FDA-approved cancer drugs are kinase inhibitors, which work by blocking kinases-;enzymes that add phosphate groups to molecules in the cell-;and preventing the chemical activity necessary for signaling and growth in cancer cells.

14 Feb 2023

Extracts from two common wild plants block SARS-CoV-2 from entering human cells

Two common wild plants contain extracts that inhibit the ability of the virus that causes COVID-19 to infect living cells, an Emory University study finds.

13 Feb 2023

A treatment strategy to hasten cancer cell death

Gene mutations are the cause of cancer. Tumor suppressors and oncogenes are the two main groups of these altered genes in cancer. Mutations in oncogenes can drive cell proliferation, pushing the gas pedal to the floor, whereas mutations in tumor suppressor genes can cause tumors to grow unchecked—a situation in which there is no control.

13 Feb 2023

Research reveals gene expression changes in two brain regions of individuals with cocaine use disorder

Individuals with cocaine use disorder exhibit gene expression changes in two brain regions: the nucleus accumbens, a region associated with reward, and the caudate nucleus, a region mediating habit formation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published February 10 in Science Advances.

13 Feb 2023

The correlation between Type 2 diabetes and human microRNAs

Although it has long been believed that microRNA (miRNA) molecules in pancreatic islets play significant roles in Type 2 diabetes, no specific miRNAs have been definitively linked to the disease in humans.

10 Feb 2023

Large-scale differentiation of iPSC-derived motor neurons from ALS patients

A new Cedars-Sinai study in collaboration with the University of California, Irvine (UCI) and the Answer ALS consortium has examined the expression of thousands of genes in stem cell generated motor neurons that are known to die in patients with amyotrophic lateral sclerosis, a fatal neurological disorder known as ALS or Lou Gehrig's disease.

10 Feb 2023

Telomeres, mitochondria, and inflammation: Working in synergy to fight cancer

The telomeres, or ends of the chromosomes, increasingly shorten as people age. Recently, Salk researchers found that when telomeres are very short, they can still interact with the mitochondria, the cell’s powerhouses.

9 Feb 2023

Oral difelikefalin could reduce the intensity of itch in patients with notalgia paresthetica

Notalgia paresthetica-;a nerve disorder characterized by a persistent itch in the upper back-;is a common and underdiagnosed condition worldwide.

9 Feb 2023

Novel combination therapy shows promise in acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive form of cancer that originates in the bone marrow, rapidly spreads to the blood and can quickly cause death if not treated promptly.

8 Feb 2023

Newly discovered gene signature accurately predicts the functioning of P53 variants

In a paper published in PNAS, Maureen Murphy, Ph.D., Deputy Director of Wistar's Ellen and Ronald Caplan Cancer Center and Ira Brind Professor and Program Leader in the Molecular & Cellular Oncogenesis Program, and team have identified a gene signature that accurately predicts the functioning of P53 variants, important information to assessing cancer risk and optimizing choices for cancer therapeutics.

7 Feb 2023

A high-throughput drug discovery assay for the endoplasmic reticulum aminopeptidase 1

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

31 Jan 2023

The Journal, Artificial Intelligence in the Life Sciences, Highlights the Contributions of Women in Artificial Intelligence in the Life Sciences

The journal, Artificial Intelligence in the Life Sciences (AILSCI), published by Elsevier, is set to release a special Themed Article Collection (TAC): Women in AI in the Life Sciences.

30 Jan 2023

Exploring how smoking cannabis alters the oral microbiome and its impact on the brain

Inspiration strikes when you least expect it. For Wei Jiang, M.D., a professor of Microbiology and Immunology at the Medical University of South Carolina (MUSC), inspiration came in 2018 on a smoke-filled boat tour around Amsterdam during an international conference.

30 Jan 2023

Cryo-EM helps visualize the detailed structure of viral genome replication machinery

RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.

30 Jan 2023

therapeutics News and Research

Accelerating the structure-guided discovery of chemogenetic tools

LLNL set off to develop vaccines to treat rheumatoid arthritis and lupus

Location is the key for psychedelic drugs to work

An innovative strategy for on-demand contraception for men

New family of pharmaceutical compounds that target RNA

Study reveals how two proteins enable drug-resistant MRSA bacterium to secrete toxins

Study explains why cancers stop responding to kinase inhibitors and come back stronger

Extracts from two common wild plants block SARS-CoV-2 from entering human cells

A treatment strategy to hasten cancer cell death

Research reveals gene expression changes in two brain regions of individuals with cocaine use disorder

The correlation between Type 2 diabetes and human microRNAs

Large-scale differentiation of iPSC-derived motor neurons from ALS patients

Telomeres, mitochondria, and inflammation: Working in synergy to fight cancer

Oral difelikefalin could reduce the intensity of itch in patients with notalgia paresthetica

Novel combination therapy shows promise in acute myeloid leukemia

Newly discovered gene signature accurately predicts the functioning of P53 variants

A high-throughput drug discovery assay for the endoplasmic reticulum aminopeptidase 1

The Journal, Artificial Intelligence in the Life Sciences, Highlights the Contributions of Women in Artificial Intelligence in the Life Sciences

Exploring how smoking cannabis alters the oral microbiome and its impact on the brain

Cryo-EM helps visualize the detailed structure of viral genome replication machinery

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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