therapeutics News and Research

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Intracellular microbiota promote cell survival during tumor progression

Bacteria promote cancer metastasis by bolstering the strength of host cells against mechanical stress in the bloodstream, promoting cell survival during tumor progression, researchers report April 7th in the journal Cell.

8 Apr 2022

Certain RNA molecules may serve as markers of cellular stress in different diseases

The body's ability to respond to various types of stress is essential for maintaining health, and failure of such adaptive stress responses can trigger or worsen numerous diseases.

6 Apr 2022

Gut microbiota may play a role in resistance to blood pressure medicines

Almost half of the U.S. adult population has high blood pressure - or hypertension - and about 20% of these patients have treatment-resistant hypertension.

6 Apr 2022

Experimental "gene silencing" therapy reduces a important driver of heart disease risk by up to 98%

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental "gene silencing" therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%.

4 Apr 2022

Exceptional research recordings display RNA switching “on” and “off”

RNA switches (also known as riboswitches) control which genes are turned “on” and “off”, much like a light switch. Although this appears to be a straightforward process, biologists have been astonished by the inner workings of these switches for decades.

1 Apr 2022

How Important are Data Clouds to Life Sciences Research?

In this interview, we speak to Mike Tarselli, CSO of TetraScience, about their Tetra data cloud and the role it plays within scientific data analysis.

From TetraScience, Inc. 31 Mar 2022

Multiple nanobodies effectively block infection with different SARS-CoV-2 variants

Researchers at Karolinska Institutet in Sweden have developed a novel strategy for identifying potent miniature antibodies, so-called nanobodies, against emerging SARS-CoV-2 variants.

28 Mar 2022

CDH17CAR T cells can eliminate solid tumors without damaging healthy tissues

Chimeric antigen receptor (CAR) T cells can be remarkably effective in treating leukemias and lymphomas, but there are no successful immunotherapies for neuroendocrine tumors (NETs) and gastrointestinal cancers (GICs) yet.

25 Mar 2022

CAR-T cell treatment via implantable biotechnology more effective in combating cancer

Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed an implantable biotechnology that produces and releases CAR-T cells for attacking cancerous tumors.

25 Mar 2022

Researchers determine novel technique for drug delivery

They have devised a novel means of delivering medicines and peptides into cells.

25 Mar 2022

Research reveals how a marine bacterium makes a potent anti-cancer molecule

Years of toil in the laboratory have revealed how a marine bacterium makes a potent anti-cancer molecule.

22 Mar 2022

Novel method to sneak large drug-carrying biological molecules into cells

Scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed a novel method of delivering drugs into human cells using large biological molecules, by first encasing them in a protein-based microdroplet.

From Nanyang Technological University Singapore (NTU Singapore) 17 Mar 2022

Novel mechanistic insight into how gut bacteria work to tame intestinal inflammation

Bile acids made by the liver have long been known for their critical role in helping to absorb the food we ingest.

From Harvard Medical School 17 Mar 2022

INTEGRA’s VIAFLO 384 proves indispensable in neurodegeneration research

Scientists at Rejuveron Vascular Therapeutics AG, a company specializing in the development of therapies to tackle neurodegeneration, are using INTEGRA’s VIAFLO 384 handheld electronic pipette to accelerate their research.

From INTEGRA Biosciences 16 Mar 2022

Genetic rat model shows robust Down syndrome features

In pursuit of better ways to test new therapies and further explore the impacts of the unique genetics associated with Down syndrome, researchers at Johns Hopkins Medicine and Tottori University in Japan have genetically engineered and characterized what is believed to be the first rat model of Down syndrome.

15 Mar 2022

Cellular therapy leads to meaningful functional improvements in DMD patients

A clinical trial at UC Davis Health and six other sites showed that a cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy (DMD), a rare genetic disorder causing muscle loss and physical impairments in young people.

From The University of California, Davis 14 Mar 2022

New method could create a promising vehicle for vaccine delivery against SARS-CoV-2

Physicists, chemists and immunologists at McMaster University have teamed up to modify red blood cells to transport viral agents which can safely trigger the immune system to protect the body against SARS-CoV-2, creating a promising new vehicle for vaccine delivery.

14 Mar 2022

Improving the long-term effectiveness of TB vaccine in mice

Briefly blocking a key molecule when administering the only approved vaccine for tuberculosis vastly improves long-term protection against the devastating disease in mice, researchers from Texas Biomedical Research Institute report this week in the Journal of Immunology.

14 Mar 2022

Orbit Discovery and WuXi AppTec sign agreement to access peptide discovery and optimisation technologies

Orbit Discovery is pleased to announce the commencement of a partnership with WuXi AppTec, a leading global provider of R&D and manufacturing services.

8 Mar 2022

New technique controls gene activity without altering the DNA sequence of the genome

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical "off switches" that silence them.

7 Mar 2022

therapeutics News and Research

Intracellular microbiota promote cell survival during tumor progression

Certain RNA molecules may serve as markers of cellular stress in different diseases

Gut microbiota may play a role in resistance to blood pressure medicines

Experimental "gene silencing" therapy reduces a important driver of heart disease risk by up to 98%

Exceptional research recordings display RNA switching “on” and “off”

How Important are Data Clouds to Life Sciences Research?

Multiple nanobodies effectively block infection with different SARS-CoV-2 variants

CDH17CAR T cells can eliminate solid tumors without damaging healthy tissues

CAR-T cell treatment via implantable biotechnology more effective in combating cancer

Researchers determine novel technique for drug delivery

Research reveals how a marine bacterium makes a potent anti-cancer molecule

Novel method to sneak large drug-carrying biological molecules into cells

Novel mechanistic insight into how gut bacteria work to tame intestinal inflammation

INTEGRA’s VIAFLO 384 proves indispensable in neurodegeneration research

Genetic rat model shows robust Down syndrome features

Cellular therapy leads to meaningful functional improvements in DMD patients

New method could create a promising vehicle for vaccine delivery against SARS-CoV-2

Improving the long-term effectiveness of TB vaccine in mice

Orbit Discovery and WuXi AppTec sign agreement to access peptide discovery and optimisation technologies

New technique controls gene activity without altering the DNA sequence of the genome

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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