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Deadly Mould Strains Highly Likely to Acquire Resistance to New Drugs

Scientists have identified strains of one of the world’s most dangerous fungal pathogens, already resistant to our most effective antifungal drugs, which are also 5-times more likely to acquire resistance to desperately needed new treatments in development.

From The University of Manchester 16 Dec 2024

Tiny RNA Molecule Controls Wing Coloration in Butterflies and Moths

Lepidopterans (butterflies and moths) exhibit a splendid diversity of wing color patterns, and many species display black and white, or dark and bright, wing color pattern variants associated with the presence and absence of melanin.

9 Dec 2024

New Class of CRISPR-Cas Enzymes for Precise Genome Editing

Recent research published in the journal “Science Bulletin” detailed the creation of a tool called ChCas12b that can accurately edit genomes and identify single-base mutations.

9 Dec 2024

New Discovery Reveals Unintended Genetic Damage in CRISPR-Cas9 Therapy

Genome editing with various CRISPR-Cas molecule complexes has progressed rapidly in recent years.

5 Dec 2024

Comprehensive Review of Intracellular Checkpoints in NK Cell Biology and Cancer

Natural killer (NK) cells play an important role in the innate immune response to cancer and viral infections, and their presence in tumors correlates with improved patient outcomes in a variety of cancers.

29 Nov 2024

Self-Eliminating e-Drive System Reverses Insecticide Resistance in Fruit Flies

Insecticides have been used for centuries to counteract widespread pest damage to valuable food crops. Eventually, over time, beetles, moths, flies and other insects develop genetic mutations that render the insecticide chemicals ineffective.

25 Nov 2024

CRISPR Reveals Hidden Functions of Noncoding RNA

Genes contain instructions for protein production, with the central dogma of biology stating that this information flows from DNA to RNA to proteins.

8 Nov 2024

3D Tumor Microenvironment Model Highlights Role of Ischemia and Acidification in Cancer Spread

Developed 3MIC model simulates tumor microenvironments, enabling direct observation of ischemic effects on cancer cell invasiveness and drug resistance.

4 Nov 2024

Unveiling the Molecular Mechanisms of CRISPR-Cas10's Cellular Shutdown

CRISPR-Cas9 can elegantly and precisely cut away any desired region of DNA and has long been compared to a type of genetic scissors.

29 Oct 2024

Mapping the Complex Structure and Function of CRISPR-Cas Protein Scissors

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions.

3 Oct 2024

Structural Discovery of Fanzor Proteins Offers New Directions in Genome Engineering

A revolution in biomedicine is currently underway, driven by the application of genome engineering tools such as the prokaryotic CRISPR-Cas9.

3 Oct 2024

Enhancing Global Nutrition Through Gene-Edited High-Protein Crops

A Mississippi State biologist's groundbreaking research in improving global nutrition and sustainability is featured this week in New Phytologist, a leading plant biology journal.

26 Sep 2024

New Gene Editing Tool Shows Promise for Treating Diseases

Bacterial and archaeal CRISPR-Cas systems, comprising protein and RNA components, were initially developed as a natural defense mechanism against invading viruses.

24 Sep 2024

CRISPR-Edited Euglena Offers Improved Biofuel Feedstock for Cold Conditions

News about biofuels sometimes mentions used cooking oil as a feedstock, but if these substances contain animal fat, they can solidify in colder temperatures.

16 Sep 2024

CRISPR and Antibodies Offer New Hope for Improving CAR-T Cell Therapy Outcomes

Mayo Clinic researchers mined the molecular foundations of cancer and uncovered a new reason chimeric antigen receptor (CAR-T cell therapy) fails in some patients.

13 Sep 2024

Global Ocean Microbiome Catalogue Opens New Frontiers In Marine Bioprospecting

Recent advancements in sequencing have led to the GOMC, a comprehensive catalog of marine microbiomes, enhancing prospects for biotechnological applications.

12 Sep 2024

New VitelloTag Method Revolutionizes Gene Editing in Egg Cells and Embryos

A new approach for delivering miniature research tools into the interior of egg cells and embryos has been developed at the Marine Biological Laboratory (MBL), resolving a major bottleneck to using the gene-editing tool CRISPR-Cas9 in many research organisms.

11 Sep 2024