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Researchers Uncover the FACT-ETS-1 Antiviral Response Pathway

By focusing on a poxvirus protein, a team led by UT Southwestern Medical Center scientists has discovered an antiviral immune pathway that broadly fights a wide variety of viruses.

4 Apr 2024

Researchers Advocate for “Pathogen Prospecting” to Fight Malaria

A team of scientists is urging colleagues worldwide to participate in what they refer to as “pathogen prospecting,” which involves locating archival mosquito specimens in collections and museums and examining them for pathogens that could have transmitted malaria to humans while feeding on their blood.

2 Apr 2024

New Research Highlights Gut's Role in Preventing Infections

According to a study published in the journal Nature, gut bacteria and a diet high in the amino acid tryptophan can protect against pathogenic E. coli, which can cause severe upset stomach, cramps, fever, intestinal bleeding, and renal failure.

14 Mar 2024

New CRISPR-Based Test Detects Mpox Faster

A rare viral illness called mpox, formerly known as monkeypox, is transmitted by direct physical contact between individuals.

12 Feb 2024

GWAS Identifies Key Genetic Factors for Lassa Fever Susceptibility and Severity

While combing through the human genome in 2007, computational geneticist Pardis Sabeti made a discovery that would transform her research career.

9 Feb 2024

Tomatoes as Nature's Antibacterial Agents

According to research published in Microbiology Spectrum, a magazine of the American Society for Microbiology, tomato juice can eliminate Salmonella Typhi and other bacteria that can damage people's digestive and urinary system health. Typhoid fever is brought on by the lethal human-specific bacterium Salmonella Typhi.

31 Jan 2024

Zika's Enzyme Cascade Holds the Key to Viral Replication

Viruses operate with limited genetic material and a sparse protein repertoire, requiring efficient utilization of their components. The Zika virus serves as an illustrative case, producing only 10 proteins.

11 Dec 2023

Novel Bacterial Protein can Prolong Cell Longevity by Acting Directly on Mitochondria

Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden.

10 Nov 2023

Study Links Adenovirus Infection With a Rare Blood Clotting Disorder

Platelets, or thrombocytes, are specialized cellular fragments that form blood clots when we get scrapes and traumatic injuries. Viral infections, autoimmune disease, and other conditions can cause platelet levels to drop throughout the body, termed thrombocytopenia.

11 Aug 2023

The Peptoid Approach to Antiviral Resistance

Antiviral therapies are difficult to develop because viruses can rapidly mutate to become drug resistant.

3 Aug 2023

EMBL-EBI Launches Pathogens Portal to Enhance Global Pathogen Surveillance

EMBL's European Bioinformatics Institute (EMBL-EBI) has launched the Pathogens Portal – an online platform that enables researchers, clinicians, and policymakers to access the most comprehensive collection of biomolecular data about pathogens.

7 Jul 2023

Researchers Develop New Way to Genetically Suppress Malaria-Carrying Mosquitoes

Malaria remains one of the world's deadliest diseases. Each year malaria infections result in hundreds of thousands of deaths, with the majority of fatalities occurring in children under five.

6 Jul 2023

Understanding How Malaria Parasite Modulates Apicoplast Gene Expression

A recent study supported by Tokyo Tech’s World Research Hub Initiative discovered that gene expression within the apicoplast, an organelle in the malaria parasite Plasmodium falciparum, is controlled by melatonin (the circadian signaling hormone) in host blood and intrinsic parasite cues via a factor called ApSigma.

5 Jul 2023

A New Class of Molecular Sensor Prevents Parasite Replication and Transmission

Malaria continues to be a serious public health issue, especially in sub-Saharan Africa, with almost 250 million cases per year and 621,000 fatalities.

19 Jun 2023

Molecular Rhythms of Malaria Parasites Sync With the Biological Clock of Human Hosts

Health officials warn that drug resistance could wipe out recent progress against malaria, particularly in Africa and southeast Asia.

7 Jun 2023

Temperature Preference of Mosquitos Identified

Mosquitoes have thermal inclinations. This is a significant parameter to better forecast outbreaks of diseases that have been transmitted by such insects.

29 May 2023

Food-Poisoning Bacteria Create Syringe-Like Structures to Inject Toxins Into Intestinal Cells

Researchers at UT Southwestern Medical Center have discovered how a bacterium that infects people after they eat raw or undercooked shellfish creates syringe-like structures to inject its toxins into intestinal cells.

21 Apr 2023

Small Vesicles Originating From Intestinal Bacteria Have an Adverse Effect on the Liver

Researchers from Niigata University and Kyoto Prefectural University have revealed that small vesicles, around 100 nm in size, released by intestinal bacteria induce immune activation and progression of liver cirrhosis, as well as reduction of serum albumin level, subsequently leading to edema and ascites.

19 Apr 2023

Study Provides Insight into the Formation of Protective Memory T Cells Against Salmonella

Salmonella infections cause about a million deaths a year worldwide, and there is an urgent need for better vaccines for both typhoid fever and non-typhoidal Salmonella disease.

18 Apr 2023

Organoid Platform Could Help Reduce the Time for Developing New Conjugate Vaccines

Developing and testing new treatments or vaccines for humans almost always requires animal trials, but these experiments can sometimes take years to complete and can raise ethical concerns about the animals' treatment.

13 Apr 2023